Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jason Y. Hokama"'
Autor:
Dean J. Kereiakes, Carlos Mena-Hurtado, Ziad A. Ali, Andrew Holden, Jason Y. Hokama, Sean P. Lyden, Jonathan Hill, Uday Illindala, Renu Virmani
Publikováno v:
JACC: Cardiovascular Interventions. 14:1275-1292
A significant proportion of lesions treated with transcatheter interventions in the coronary and peripheral vascular beds exhibit moderate to severe calcific plaques known to portend lower procedural success rates, increased peri-procedural adverse e
Autor:
Paul F. McDonagh, Grace Davis-Gorman, Jason Y. Hokama, Jack G. Copeland, Steve Goldman, Stephen C. Gale, Jeremy J Logan
Publikováno v:
Journal of Diabetes and its Complications. 17:269-278
Cardiac ischemia is a serious complication of type 2 diabetes. However, the pathophysiology underlying the increased severity of myocardial ischemia in diabetes is not clear. This study tested the hypothesis that platelet adhesion protein expression
Autor:
Paul F. McDonagh, Jason Y. Hokama
Publikováno v:
Microcirculation. 7:163-181
Diabetes is a chronic disease of metabolic dysfunction that is increasing world-wide. The hyperglycemia associated with diabetes causes significant protein alterations and an oxidative stress. In the heart, all cell types are affected by diabetes: th
Autor:
Grace Davis-Gorman, Adriana D. Cimetta, Paul F. McDonagh, Jason Y. Hokama, Jack G. Copeland, Leslie S. Ritter
Publikováno v:
Journal of Diabetes and its Complications. 14:96-107
Diabetic hearts are particularly vulnerable to ischemia-reperfusion injury. For leukocytes to participate in ischemia-reperfusion injury, they must first sequester in the microcirculation. The aim of this study was to determine, by direct observation
Autor:
Donovan L. Fogt, Ryan S. Streeper, Erik J. Henriksen, Stephan Jacob, Gunther Dietze, Jason Y. Hokama, Hans J. Tritschler
Publikováno v:
Diabetes. 45:1024-1029
Insulin resistance of muscle glucose metabolism is a hallmark of NIDDM. The obese Zucker (fa/fa) rat—an animal model of muscle insulin resistance—was used to test whether acute (100 mg/kg body wt for 1 h) and chronic (5–100 mg/kg for 10 days) p
Autor:
Paul F, McDonagh, Jason Y, Hokama, Stephen C, Gale, Jeremy J, Logan, Grace, Davis-Gorman, Steve, Goldman, Jack G, Copeland
Publikováno v:
Journal of diabetes and its complications. 17(5)
Cardiac ischemia is a serious complication of type 2 diabetes. However, the pathophysiology underlying the increased severity of myocardial ischemia in diabetes is not clear. This study tested the hypothesis that platelet adhesion protein expression
Autor:
George Lai, Jack G. Copeland, Kristen Cerney, Grace Davis-Gorman, Paul F. McDonagh, Jason Y. Hokama, Raoul Gonzales
Publikováno v:
The Journal of surgical research. 99(1)
The recovery from cardiac surgery and cardiopulmonary bypass can be complicated by an acute inflammatory response. Circulating blood through an extracorporeal circuit (ECC) contributes to this complication. Perfluorocarbon-based blood substitutes (PF
Autor:
Paul F. McDonagh, Jason Y. Hokama, Stephen C. Gale, Jack G. Copeland, Leslie S. Ritter, Grace D. Gorman
Publikováno v:
The Annals of thoracic surgery. 71(4)
Background . Ischemia/reperfusion injury can complicate recovery in cardiac operations. Ischemia induces endothelial dysfunction, which may contribute to leukocyte accumulation during reperfusion. Leukocyte-mediated injury may then occur. Using intra
Publikováno v:
Diabetes. 46(11)
Cardiovascular disease is excessive in diabetes, and blood cell function is altered. It is not clear, however, if alterations in the blood contribute to the excessive cardiovascular complications of this disease. In this study, we compared the contri
Autor:
Stephan Jacob, Hans J. Tritschler, Donovan L. Fogt, Jason Y. Hokama, Ryan S. Streeper, Erik J. Henriksen
Publikováno v:
The American journal of physiology. 273(1 Pt 1)
The racemic mixture of the antioxidant alpha-lipoic acid (ALA) enhances insulin-stimulated glucose metabolism in insulin-resistant humans and animals. We determined the individual effects of the pure R-(+) and S-(-) enantiomers of ALA on glucose meta