Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Jason Witherington"'
Autor:
W. Colin Duncan, Linda M. Nicol, Rosie O’Hare, Jason Witherington, Jason A. Miranda, Bruce K. Campbell, Jennifer L. Thomas, Michael T. Rae
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionPolycystic ovary syndrome (PCOS) seems to be associated with increased ovarian sympathetic nerve activity and in rodent models of PCOS reducing the sympathetic drive to the ovary, through denervation or neuromodulation, improves ovulation
Externí odkaz:
https://doaj.org/article/034c568c898943fa876ffe8819c8519c
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Sympathetic innervation of the ovary in rodents occurs via two routes: the superior ovarian nerve (SON), which runs along the ovarian ligament, and the plexus nerve (PN), which is mainly associated with the vasculature. SON and ovarian norepinephrine
Externí odkaz:
https://doaj.org/article/d0c103fc5cc94546abaaefd766ff88b6
Autor:
Jaime Viscasillas, Cathrine T Fjordbakk, Paul McGill, Jason A. Miranda, Daniel J. Chew, Matteo Donegà, Abbe H. Crawford, Dirk Werling, Jason Witherington, Justin Perkins, Joseph Kirk, Simon Cook, Thaleia-Rengina Stathopoulou, Alex McSloy, Isha Gupta, Hunsberger Gerald Edwin, Alison Rowles, David Goodwin, Wesley Dopson, David M. Sokal
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Bioelectronic modulation of the autonomic nervous system innervating the spleen represents a new therapeutic avenue. Studies in rodents suffer from the limitation that stimulation parameters and anatomy are not directly applicable to hum
Autor:
Refet Firat Yazicioglu, Daniel J. Chew, Antonino M. Cassarà, Kourosh Saeb-Parsy, Matthew A. Schiefer, Paul McGill, Alison Rowles, Isha Gupta, Niels Kuster, Paul B Matteucci, David M. Sokal, Matteo Donegà, Wesley Dopson, Sebastien Ouchouche, Esra Neufeld, Jason A. Miranda, Ilya Tarotin, Jason Witherington, Justin Perkins, Nikola Dolezalova
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Communications Biology
Communications Biology, 3 (1)
Communications Biology
Communications Biology, 3 (1)
Neuromodulation is a new therapeutic pathway to treat inflammatory conditions by modulating the electrical signalling pattern of the autonomic connections to the spleen. However, targeting this sub-division of the nervous system presents specific cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801db54c1f66fd853795a59ed59f7f60
Autor:
Aarti Patel, Nigel Deeks, Maxine A. Taylor, Jason Witherington, Dung Nguyen, Robert J. Watson, Rino A. Bit, Fiona McClure, Emmanuel Hubert Demont, James Gray, Holly Ashall, Steve R. Hood, Simon Taylor
Publikováno v:
Journal of Medicinal Chemistry. 58:8236-8256
This article describes the finding of substantial upregulation of mRNA and enzymes of the cytochrome P450 1A family during a lead optimization campaign for small molecule S1P1 agonists. Fold changes in mRNA up to 10,000-fold for CYP1A1 in vivo in rat
Autor:
Robert J. Watson, David Norton, John Skidmore, Christopher N. Johnson, Gerard Martin Paul Giblin, Jennifer Sweeting, Rivers Dean Andrew, Mahmood Ahmed, Andrea C. Haynes, Ian D. Wall, Sally Redshaw, Karen Louise Philpott, Jason Witherington, David N. Hurst, Umesh Kumar, James Myatt, Simon Taylor, Emmanuel Hubert Demont, Alexander J. Stevens, Tom D. Heightman, Rino A. Bit, D. Vesey, Jag Paul Heer, Andrew Peter Cridland
Publikováno v:
Journal of Medicinal Chemistry. 57:10424-10442
The efficacy of the recently approved drug fingolimod (FTY720) in multiple sclerosis patients results from the action of its phosphate metabolite on sphingosine-1-phosphate S1P1 receptors, while a variety of side effects have been ascribed to its S1P
Autor:
Colin A. Campbell, Martin Rüdiger, Kevin Lee, Jason Witherington, Isobel Harada, Rab K. Prinjha, Umesh Kumar, Simon Taylor, Neil D. Christensen, Rebecca C. Furze, Ian D. Holyer, Mary A. Morse, Sarah A. Brendle, Mao X. Chen, Jonathan Thomas Seal, Karla K. Balogh
Publikováno v:
Antiviral research. 154
The DNA papillomaviruses infect squamous epithelium and can cause persistent, benign and sometimes malignant hyperproliferative lesions. Effective antiviral drugs to treat human papillomavirus (HPV) infection are lacking and here we investigate the a
Autor:
W J de Jonge, Margriet J. Vervoordeldonk, Olaf Welting, H. P. van Hamersveld, Jason Witherington, Arun Sridhar, Rose Willemze, Harold Darwinkel, Joost H.A. Folgering, Jurgen Seppen, Sybren L. Meijer
Publikováno v:
Neurogastroenterology and motility, 30(3). Wiley-Blackwell
Background Vagus nerve stimulation is currently clinically evaluated as a treatment for inflammatory bowel disease. However, the mechanism by which this therapeutic intervention can have an immune-regulatory effect in colitis remains unclear. We dete
Autor:
Stephen John Atkinson, Chun-wa Chung, Peter Ernest Soden, Laurie J. Gordon, Rab K. Prinjha, Nicholas Smithers, Rebecca C. Furze, Kathryn A. Giblin, Davina C. Angell, Marcus Bantscheff, Nigel J. Parr, Inmaculada Rioja, Jason Witherington, Gerard Drewes
Publikováno v:
MedChemComm. 5:342-351
Herein we describe the design and synthesis of a dual active histone deacetylase (HDAC)/bromodomain and extra terminal (BET) small molecule tool inhibitor, DUAL946 (1). Exploiting our extensive epigenetic toolbox, we achieved the functionalisation of
Organolithium-induced ring-opening of aziridines of 2,5-dihydrofuran (5 and 8) and 1,4-dimethoxybut-2-ene (16, 17 and 23) gives 3-substituted 2-aminobut-3-en-1-ols 9–15 and amino ethers 18–20 and 24–26.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11c43239b915733c3e16cb4d46a6ea4
https://doi.org/10.1039/b409486g
https://doi.org/10.1039/b409486g