Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Jason Waithman"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T cells engineered to express chimeric-antigen receptors (CAR-T cells) can effectively control relapsed and refractory haematological malignancies in the clinic. However, the successes of CAR-T cell therapy have not been recapitulated in solid tumour
Externí odkaz:
https://doaj.org/article/fa242560a31a4b1d922320b9532f4577
Autor:
James F. Read, Michael Serralha, Jesse D. Armitage, Muhammad Munir Iqbal, Mark N. Cruickshank, Alka Saxena, Deborah H. Strickland, Jason Waithman, Patrick G. Holt, Anthony Bosco
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundHuman perinatal life is characterized by a period of extraordinary change during which newborns encounter abundant environmental stimuli and exposure to potential pathogens. To meet such challenges, the neonatal immune system is equipped wi
Externí odkaz:
https://doaj.org/article/757825dc49e34f18910ecb96025b5e67
Autor:
Samantha A. Barnes, Katherine M. Audsley, Hannah V. Newnes, Sonia Fernandez, Emma de Jong, Jason Waithman, Bree Foley
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Natural killer (NK) cells have an intrinsic ability to detect and eliminate leukaemic cells. Cellular therapies using cytokine-activated NK cells have emerged as promising treatments for patients with advanced leukaemia. However, not all patients res
Externí odkaz:
https://doaj.org/article/4328a758f5d84ac1bf6fdc0baf884824
Autor:
Kai R. Plunkett, Jesse D. Armitage, Andrisha-Jade Inderjeeth, Alison M. McDonnell, Jason Waithman, Peter K. H. Lau
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Tissue-resident memory T (TRM) cells have emerged as key players in the immune control of melanoma. These specialized cells are identified by expression of tissue retention markers such as CD69, CD103 and CD49a with downregulation of egress molecules
Externí odkaz:
https://doaj.org/article/ab77b270524041de98422a914113d3b0
Autor:
Jonathan Chee, Chelsea Wilson, Anthony Buzzai, Ben Wylie, Catherine A Forbes, Mitchell Booth, Nicola Principe, Bree Foley, Mark N Cruickshank, Jason Waithman
Publikováno v:
Epigenetics, Vol 15, Iss 1-2, Pp 134-144 (2020)
Activation of naïve CD8+ T cells stimulates proliferation and differentiation into cytotoxic T-lymphocytes (CTLs). Adoptive T Cell Therapy (ACT) involves multiple rounds of ex vivo activation to generate enough CTLs for reinfusion into patients, but
Externí odkaz:
https://doaj.org/article/d828f4c443114fb39e8b6402758650c5
Autor:
Katherine M. Audsley, Teagan Wagner, Clara Ta, Hannah V. Newnes, Anthony C. Buzzai, Samantha A. Barnes, Ben Wylie, Jesse Armitage, Tsuneyasu Kaisho, Anthony Bosco, Alison McDonnell, Mark Cruickshank, Vanessa S. Fear, Bree Foley, Jason Waithman
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Cancer vaccination drives the generation of anti-tumor T cell immunity and can be enhanced by the inclusion of effective immune adjuvants such as type I interferons (IFNs). Whilst type I IFNs have been shown to promote cross-priming of T cells, the r
Externí odkaz:
https://doaj.org/article/b56b112c536b49278342654b74c0c736
Autor:
Anthony C. Buzzai, Teagan Wagner, Katherine M. Audsley, Hannah V. Newnes, Lucy W. Barrett, Samantha Barnes, Ben C. Wylie, Shane Stone, Alison McDonnell, Vanessa S. Fear, Bree Foley, Jason Waithman
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Immunotherapies harnessing T cell immunity have shown remarkable clinical success for the management of cancer. However, only a proportion of patients benefit from these treatments. The presence of type I interferon (IFN) within the tumor microenviro
Externí odkaz:
https://doaj.org/article/35687a14dd114b22a8db2f4f26dbccf5
Autor:
Bree Foley, Clara Ta, Samantha Barnes, Emma deJong, Michelle Nguyen, Laurence C Cheung, Anthony Buzzai, Teagan Wagner, Ben Wylie, Sonia Fernandez, Mark Cruickshank, Raelene Endersby, Ursula Kees, Jason Waithman
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 7, Pp n/a-n/a (2020)
Abstract Objectives Natural killer (NK) cells are an attractive source of cells for an ‘off the shelf’ cellular therapy because of their innate capacity to target malignant cells, and ability to be transferred between donors and patients. However
Externí odkaz:
https://doaj.org/article/b39a74c39e6b4df1919f693bffd272b6
Publikováno v:
Cell Stress, Vol 3, Iss 5, Pp 162-164 (2019)
The immune system can prevent tumour development by engaging in a process termed cancer immunosurveillance, during which immune cells such as T cells restrict tumour growth either by completely eradicating cancer cells in a process of ‘elimination
Externí odkaz:
https://doaj.org/article/0c194e3779e347ea9660a1ee03a6f03b
Publikováno v:
Frontiers in Medicine, Vol 6 (2019)
Externí odkaz:
https://doaj.org/article/13bcbafb9cbb4035be1c785831b3e28b