Výsledky vyhledávání - "Jason W.-L. Eng"

Akademický článek

Pancreatic cancer stem cells in patient pancreatic xenografts are sensitive to drozitumab, an agonistic antibody against DR5

Autor: Rohit Sharma, Thomas A. Mace, Scott I. Abrams, Jason W.-L. Eng, Danielle Y. F. Twum, Peng Peng, John F. Gibbs, Rosemarie Pitoniak, Chelsey B. Reed, Elizabeth A. Repasky, Bonnie L. Hylander

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016)

Background Therapeutic resistance and tumor recurrence are two major hurdles in the treatment of pancreatic ductal adenocarcinoma. Recent findings suggest that both of these attributes are associated with a small subset of pancreatic tumor initiating

Externí odkaz: https://doaj.org/article/789b054228df43e5ba00b870dbd1141a

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Figure S6 from β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy

Autor: Elizabeth A. Repasky, Bonnie L. Hylander, Scott I. Abrams, Kristopher Attwood, Michelle N. Messmer, Jason W.-L. Eng, Kathleen M. Kokolus, Haichao Liu, Brian Niedzwecki, Lauren Evans, Thejaswini Giridharan, Cameron R. MacDonald, Guanxi Qiao, Mark J. Bucsek

This data shows that housing mice at 30 degrees Celsius improves the efficacy of anti-PD-1 in both 4T1 and B16-OVA tumor-bearing mice indicating that cool housing temperatures (22 degrees C) impairs the efficacy of anti-PD-1 in murine tumor models.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600baffff9aca5eeba91cd8561516aec
https://doi.org/10.1158/0008-5472.22414770

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Data from β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy

The immune context of tumors has significant prognostic value and is predictive of responsiveness to several forms of therapy, including immunotherapy. We report here that CD8+ T-cell frequency and functional orientation within the tumor microenviron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aec282661638d66a258465c3d3cac9c3
https://doi.org/10.1158/0008-5472.c.6509076.v1

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Abstract 4605: Chronic VEGF-C signaling exacerbates the progression of non-alcoholic steatohepatitis and hepatocarcinoma through endothelial VEGFR2 and VEGFR3

Autor: Seock-Won Youn, Jason W.-L. Eng, Bhairavi Swaminathan, Pamela Teneqexhi, Rahul Vadakath, Jan K. Kitajewski

Publikováno v: Cancer Research. 83:4605-4605

Obesity, aging, and metabolic diseases contribute to non-alcoholic fatty liver disease (NAFLD) that can progress to non-alcoholic steatohepatitis (NASH) due to ongoing inflammation and pathological angiogenesis. At present, NASH is a leading cause of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eccd13771c382e56b9102816e9aaaef0
https://doi.org/10.1158/1538-7445.am2023-4605

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Akademický článek

Standard sub-thermoneutral caging temperature influences radiosensitivity of hematopoietic stem and progenitor cells.

Autor: Benjamin J Povinelli, Kathleen M Kokolus, Jason W-L Eng, Christopher W Dougher, Leslie Curtin, Maegan L Capitano, Christi T Sailsbury-Ruf, Elizabeth A Repasky, Michael J Nemeth

Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0120078 (2015)

The production of new blood cells relies on a hierarchical network of hematopoietic stem and progenitor cells (HSPCs). To maintain lifelong hematopoiesis, HSPCs must be protected from ionizing radiation or other cytotoxic agents. For many years, muri

Externí odkaz: https://doaj.org/article/4d9fa4f85cf1444286bb1db75d6880c6

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β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy

Autor: Cameron R. MacDonald, Scott I. Abrams, Thejaswini Giridharan, Bonnie L. Hylander, Mark J. Bucsek, Jason W.-L. Eng, Haichao Liu, Guanxi Qiao, Kathleen M. Kokolus, Michelle N. Messmer, Kristopher Attwood, Brian Niedzwecki, Lauren Evans, Elizabeth A. Repasky

Publikováno v: Cancer Research. 77:5639-5651

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0fc95a94119c3469756bedd1f6b3c8d
https://doi.org/10.1158/0008-5472.can-17-0546

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Housing Temperature–Induced Stress Is Suppressing Murine Graft-versus-Host Disease through β2-Adrenergic Receptor Signaling

Autor: Rachel E. O’Neill, Philip L. McCarthy, Kathleen M. Kokolus, Jason W.-L. Eng, George Chen, Xuefang Cao, Wei Du, J. David Farrar, Nicholas D. Leigh, Elizabeth A. Repasky, Jingxin Qiu

Publikováno v: The Journal of Immunology. 195:5045-5054

Graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic cell transplantation, a potentially curative therapy for hematologic diseases. It has long been thought that murine bone marrow–derived T cells do not mediate se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b34c4ba80b16059889e0e8678ab97fab
https://doi.org/10.4049/jimmunol.1500700

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The Impact of Housing Temperature-Induced Chronic Stress on Preclinical Mouse Tumor Models and Therapeutic Responses: An Important Role for the Nervous System

Autor: Elizabeth A. Repasky, Bonnie L. Hylander, Jason W.-L. Eng

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9783319675756
Adv Exp Med Biol

In the last 10– 15 years, there has been a recognition that the catecholamines (norepinephrine, NE, and epinephrine, Epi) released by the sympathetic nervous system under stressful conditions promote tumor growth through a variety of mechanisms. Tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e54a465689df3d6d53f12219be83248
https://doi.org/10.1007/978-3-319-67577-0_12

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A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response

Autor: Elizabeth A. Repasky, Wen Wee Ma, Chelsey B. Reed, Bonnie L. Hylander, Jason W.-L. Eng, Kathleen M. Kokolus

Publikováno v: Cancer Immunology, Immunotherapy. 63:1115-1128

Long conserved mechanisms maintain homeostasis in living creatures in response to a variety of stresses. However, continuous exposure to stress can result in unabated production of stress hormones, especially catecholamines, which can have detrimenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed5df43057da4f550944092ae1aa907
https://doi.org/10.1007/s00262-014-1617-9

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Mild cold-stress depresses immune responses: Implications for cancer models involving laboratory mice

Autor: Kathleen M. Kokolus, Jason W.-L. Eng, Scott I. Abrams, Elizabeth A. Repasky, Michelle N. Messmer

Publikováno v: BioEssays. 36:884-891

Physiologically accurate mouse models of cancer are critical in the pre-clinical development of novel cancer therapies. However, current standardized animal-housing temperatures elicit chronic cold-associated stress in mice, which is further increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9dd7d6e67383e4d1fbfbb9a554d43bdf
https://doi.org/10.1002/bies.201400066

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