Výsledky vyhledávání - "Jason W. Y. Kan"

Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)

Autor: Tsz Cheung, Chong, Iris L K, Wong, Jiahua, Cui, Man Chun, Law, Xuezhen, Zhu, Xuesen, Hu, Jason W Y, Kan, Clare S W, Yan, Tak Hang, Chan, Larry M C, Chow

Publikováno v: International journal of molecular sciences. 23(21)

Overexpression of breast cancer resistance transporter (BCRP/ABCG2) in cancers has been explained for the failure of chemotherapy in clinic. Inhibition of the transport activity of BCRP during chemotherapy should reverse multidrug resistance. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37c1ff8947a2264dd2d4dfa61a2d7324
https://pubmed.ncbi.nlm.nih.gov/36362047

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Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel

Autor: Jason W. Y. Kan, Clare S. W. Yan, Iris L. K. Wong, Xiaochun Su, Zhen Liu, Tak Hang Chan, Larry M. C. Chow

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 15299

Biotransformation of flavonoid dimer FD18 resulted in an active metabolite FM04. It was more druggable because of its improved physicochemical properties. FM04 (EC50 = 83 nM) was 1.8-fold more potent than FD18 in reversing P-glycoprotein (P-gp)-media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297ab9288971f1e08816d2d7236731c5
https://doi.org/10.3390/ijms232315299

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Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)2, in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2)

Autor: Tsz Cheung Chong, Iris L. K. Wong, Jiahua Cui, Man Chun Law, Xuezhen Zhu, Xuesen Hu, Jason W. Y. Kan, Clare S. W. Yan, Tak Hang Chan, Larry M. C. Chow

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13261

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc56dda97d37d099c8205962b712286b
https://doi.org/10.3390/ijms232113261

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A New Class of Safe, Potent, and Specific P-gp Modulator: Flavonoid Dimer FD18 Reverses P-gp-Mediated Multidrug Resistance in Human Breast Xenograft in Vivo

Autor: Yunzhe Zhao, Man Chun Law, Tsz Cheung Chong, Kin-Fai Chan, Larry M.C. Chow, Shun Wan Chan, Tak Hang Chan, Jason W. Y. Kan, Clare S. W. Yan, Iris L. K. Wong

Publikováno v: Molecular Pharmaceutics. 12:3507-3517

Flavonoid dimer FD18 is a new class of dimeric P-gp modulator that can reverse cancer drug resistance. FD18 is a potent (EC50 = 148 nM for paclitaxel), safe (selective index = 574), and selective P-glycoprotein (P-gp) modulator. FD18 can modulate mul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc900f3d335ceefd336976a0e34f4f8
https://doi.org/10.1021/mp500770e

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Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation

Autor: Kin-Fai Chan, Jason W. Y. Kan, Iris L. K. Wong, Tak Hang Chan, Larry M.C. Chow, Clare S. W. Yan

Publikováno v: Journal of medicinal chemistry. 55(5)

Here we report a great improvement in reversal potency of cancer drug resistance when flavonoid dimers possess a functionally substituted aminopolyethylene glycol linker. The most potent compound, 18, contains a N-benzyl group at the linker. It has m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d6ee59b8af3776985ae77380c3e0cb
https://pubmed.ncbi.nlm.nih.gov/22320402

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