Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jason W. Tam"'
Autor:
Meng Deng, Jason W. Tam, Lufei Wang, Kaixin Liang, Sirui Li, Lu Zhang, Haitao Guo, Xiaobo Luo, Yang Zhang, Alex Petrucelli, Beckley K. Davis, Brian J. Conti, W. June Brickey, Ching-Chang Ko, Yu L. Lei, Shaocong Sun, Jenny P. -Y. Ting
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
RNA viruses can be detected by immune cell pattern recognition receptors, such as RLRs, resulting in MAVS-TBK1-IRF3 signalling and production of antiviral type 1 interferons. Here the authors show that macrophage TRAF3-interacting protein 3 regulates
Externí odkaz:
https://doaj.org/article/17cacfe2c68542b2a667a747cf1f862c
Autor:
Patrick A McLaughlin, Julie A Bettke, Jason W Tam, Jesse Leeds, James B Bliska, Brian P Butler, Adrianus W M van der Velden
Publikováno v:
PLoS Pathogens, Vol 15, Iss 7, p e1007847 (2019)
Salmonella exploit host-derived nitrate for growth in the lumen of the inflamed intestine. The generation of host-derived nitrate is dependent on Nos2, which encodes inducible nitric oxide synthase (iNOS), an enzyme that catalyzes nitric oxide (NO) p
Externí odkaz:
https://doaj.org/article/5fcbff48d5b4444f8a2ef57e56417a82
Autor:
Julie A, Bettke, Jason W, Tam, Valeria, Montoya, Brian P, Butler, Adrianus W M, van der Velden
Publikováno v:
Infect Immun
Persistent infections generally involve a complex balance between protective immunity and immunopathology. We used a murine model to investigate the role of inflammatory monocytes in immunity and host defense against persistent salmonellosis. Mice ex
Autor:
W. June Brickey, Shao Cong Sun, Beckley K. Davis, Kaixin Liang, Jenny P.-Y. Ting, Lufei Wang, Jason W. Tam, Sirui Li, Yang Zhang, Alex Petrucelli, Haitao Guo, Brian J. Conti, Meng Deng, Ching-Chang Ko, Lu Zhang, Yu Lei, Xiaobo Luo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Innate immunity to nucleic acids forms the backbone for anti-viral immunity and several inflammatory diseases. Upon sensing cytosolic viral RNA, retinoic acid-inducible gene-I-like receptors (RLRs) interact with the mitochondrial antiviral signaling
Autor:
Viswanathan A, Yury Popov, Jason W. Tam, Corinna Bang, Andre Franke, Jenny P.-Y. Ting, Muyiwa Awoniyi, Schnabl B, Farmer M, Yunjia Lai, Martin Kummen, Kun Lu, Hov, Louise B. Thingholm, Stephanie A. Montgomery, Francis H, Jin Wang, Christoph Schramm, Ngo B, Ryan Balfour Sartor, Meadows
ObjectiveConflicting microbiota data exist for primary sclerosing cholangitis (PSC) and experimental models. Goal: Define complex interactions between resident microbes and their association in PSC patients by studying antibiotic-treated specific pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58ab65f50d5acd504e96d1763f9075c8
https://doi.org/10.1101/2021.10.31.466701
https://doi.org/10.1101/2021.10.31.466701
Publikováno v:
PLoS Pathogens, Vol 11, Iss 10, p e1005167 (2015)
During Yersinia pseudotuberculosis infection of C57BL/6 mice, an exceptionally large CD8+ T cell response to a protective epitope in the type III secretion system effector YopE is produced. At the peak of the response, up to 50% of splenic CD8+ T cel
Externí odkaz:
https://doaj.org/article/fe8dafd6c2f8428aa514e7362685fe50
Autor:
Matthew D. Gallovic, Sara A. Gibson, Brandon M. Johnson, Kristy M. Ainslie, Jonathan W. Williams, Wei-Chun Chou, Cole J. Batty, Jenny P.-Y. Ting, Glenn K. Matsushima, Eric M. Bachelder, Meng Deng, Jason W. Tam, Toru Uchimura, Silva Markovic-Plese, Madhan Thamilarasan
Publikováno v:
J Immunol
The cGAS–cyclic GMP–AMP (cGAMP)–stimulator of IFN genes (STING) pathway induces a powerful type I IFN (IFN-I) response and is a prime candidate for augmenting immunity in cancer immunotherapy and vaccines. IFN-I also has immune-regulatory funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c282d3bd55213316e3585e70877c11c5
https://europepmc.org/articles/PMC8406342/
https://europepmc.org/articles/PMC8406342/
Autor:
Jonathan U. Peled, Kun Lu, Yunjia Lai, Andrew N. Macintyre, Jenny P.-Y. Ting, W. June Brickey, R. Balfour Sartor, Matthew J. French, Jason W. Tam, Kaixin Liang, Xin Li, Hao Guo, Antonio L.C. Gomes, Nathan D. Montgomery, Xianming Tan, Anthony D. Sung, Lauren Bohannon, Marcel R.M. van den Brink, Gregory D. Sempowski, Wei-Chun Chou, Liang Chen, Nelson J. Chao
Publikováno v:
Science
Ionizing-radiation causes acute radiation syndrome leading to hematopoietic, gastrointestinal and cerebrovascular injuries. Substantial federal efforts have been made to develop therapeutic radioprotectants for routine clinical use, however it remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d34635e68207aadee6dbd5314eecaf8
Autor:
Chih Wei Chao, Jenny P.-Y. Ting, Yen Po Tsao, Ivan Dzhagalov, Liang Chen, Moon Jung Song, Hye Ri Kang, Diego Shih Chieh Lin, Szu Ting Chen, W. June Brickey, Fei Ju Li, Haitao Guo, Sei Yi Chen, Jae U. Jung, Jason W. Tam, Wei Ting Tseng
Establishing the balance between positive and negative innate immune mechanisms is crucial for maintaining homeostasis. Here we uncover the regulatory crosstalk between two previously unlinked innate immune receptor families: RIG-I, an anti-viral cyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae67987f1a9c1ebef8b0976aa36bddc
https://europepmc.org/articles/PMC6459718/
https://europepmc.org/articles/PMC6459718/
Autor:
W. June Brickey, Meng Deng, Xianming Tan, Kevin D. Cook, Yoshitaka Oyama, Haitao Guo, Alex Petrucelli, Elena Rampanelli, Ichiro Misumi, Jason W. Tam, Jenny P.-Y. Ting, Justin E. Wilson, Jason K. Whitmire, Brandon M. Johnson, Toru Uchimura, Wei-Chun Chou, Liang Chen
NLRC3 limits inflammatory signaling in myeloid cells, but its role in T cells has been unclear. Uchimura et al. reveal that T cell expression of Nlrc3 restricts autoimmune and virus-specific CD4 + T cell responses by attenuating T cell signaling and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a32cf09fb020ee463aaaa09c4cb5a38