Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jason W. J. Kennedy"'
Autor:
Alois Fürstner, Jason W. J. Kennedy
Publikováno v:
Chemistry - A European Journal. 12:7398-7410
A concise, efficient and modular approach to the tylophora alkaloids is described, a family of potent cytotoxic agents that are equally effective against drug sensitive and multidrug resistant cancer cell lines. The advantages of the chosen route are
Autor:
Jason W. J. Kennedy, Dennis G. Hall
Publikováno v:
The Journal of Organic Chemistry. 69:4412-4428
A full account of the development of the first catalytic manifold for the additions of allylboronates to aldehydes is described. The thermal additions (both diastereospecific and enantioselective) of 2-carboxyester 3,3-disubstituted allylboronates 1
Autor:
Jason W. J. Kennedy, Dennis G. Hall
Publikováno v:
Angewandte Chemie. 115:4880-4887
Bor- und Silicium-Allylierungsreagentien sind bei stereokontrollierten Synthesen zwar weit verbreitet, ihre Anwendung unterliegt aber einer Reihe von Einschrankungen, die ihre Weiterentwicklung als Synthesereagentien fur nucleophile Additionen an Car
Autor:
Jason W. J. Kennedy, Dennis G. Hall
Publikováno v:
Journal of Organometallic Chemistry. 680:263-270
The [4+2] cycloaddition of ortho -boronoanilide dienophile 4 with cyclopentadiene was found to proceed faster than both its para isomer 8 and the unsubstituted derivative 6 , thereby confirming that self-activation by internal coordination is operati
Autor:
David O. Miller, Jason W. J. Kennedy, Tadeusz M. Krygowski, John N. Bridson, Graham J. Bodwell, Michael R. Mannion, Michal K. Cyrañski
Publikováno v:
The Journal of Organic Chemistry. 68:2089-2098
A series of 1,n-dioxa[n](2,7)pyrenophanes (n = 7−12) with increasingly nonplanar pyrene moieties was synthesized by a 9−10 step sequence starting from 5-hydroxyisophthalic acid. The crystal structure of each member of this series was determined c
Publikováno v:
Chemistry - A European Journal. 5:1823-1827
Themostdistortedpyrenemoietyyetprepared (see picture) has been synthesized by the valence isomerization of a tethered [2.2]metacyclophane-1,9-diene to a 10b,10c-dihydropyrene and in situ dehydrogenation by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (D
Publikováno v:
ChemInform. 28
Publikováno v:
ChemInform. 27
Autor:
Jason W. J. Kennedy, Dennis G. Hall
Publikováno v:
ChemInform. 33
In spite of their inherent isomerization tendency and low reactivity, 1-alkoxycarbonyl vinylcopper(I) intermediates from the conjugate addition of organocuprates onto acetylenic esters were trapped with very high cis-addition selectivity with iodomet
Publikováno v:
ChemInform. 39
A general and efficient route to 2-substituted 1,3-cyclopentadiones 3 has been developed. This operationally simple, two-step procedure is amenable to multigram scale preparations of these useful synthetic intermediates. These compounds are then tran