Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models

Autor: Alessia Bottos, Dagmar Gotthardt, Jason W. Gill, Albana Gattelli, Anna Frei, Alexandar Tzankov, Veronika Sexl, Aleksandra Wodnar-Filipowicz, Nancy E. Hynes

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

JAK inhibitors are currently undergoing evaluation in clinical trials for advanced breast cancer. Here, the authors show that JAK pathway inhibition increases metastasis in mouse models of breast cancer by impairing NK anti-tumour activity and that t

Externí odkaz: https://doaj.org/article/86420aae63434acfa4d1039c29037e97

Contributors

Autor: Russell C. Addis, Bruce Alberts, Michal Amit, Peter W. Andrews, Hitomi Aoki, Makoto Asashima, Joyce Axelman, Daniel Becker, Nissim Benvenisty, Mickie Bhatia, C. Clare Blackburn, Michele Boiani, Susan Bonner-Weir, Josephine Bowles, Richard L. Boyd, Marianne Bronner-Fraser, Eric W. Brunskill, Scott Bultman, Frederick Charles Campbell, Anne Camus, Melissa K. Carpenter, Fatima Cavaleri, Constance Cepko, Yijing Chen, Susana M. Chuva de Sousa Lopes, Gregory O. Clark, Jérôme Collignon, Paul Collodi, Chad Cowan, George Q. Daley, Christian Dani, Joshua D. Dowell, Jonathan S. Draper, Gregory R. Dressler, Micha Drukker, Gabriela Durcova-Hills, Robert G. Edwards, Rebecca S. Eisenberg, Ravindhra Elluru, Sir Martin Evans, Lianchun Fan, Margaret A. Farley, Donna M. Fekete, Loren J. Field, Donald W. Fink, Lesley M. Forrester, Margaret T. Fuller, Miho Furue, David L. Garbers, Richard L. Gardner, John D. Gearhart, Sharon Gerecht-Nir, Jason W. Gill, Rodolfo Gonzalez, Daniel H.D. Gray, Ronald M. Green, Michal Gropp, Alexandra Haagensen, F. Kent Hamra, Richard P. Harvey, Susan M. Hawes, Shin-Ichi Hayashi, Anne L. Hazlehurst, Hiroaki Hemmi, Hiroshi Hisatsune, James Huettner, Bradley Huntsman, Catherine Iéhlé, Jamie Imitola, Joseph Itskovitz-Eldor, Rudolf Jaenisch, Penny A. Johnson, D. Leanne Jones, Elizabeth A. Jones, Gerard Karsenty, Gil Katz, Pritinder Kaur, Robert G. Kelly, Kathleen C. Kent, Candace L. Kerr, Ali Khademhosseini, Hanita Khaner, Chris Kintner, Irina Klimanskaya, Nobuyuki Kondoh, Peter Koopman, Naoko Koyano-Nakagawa, Jennifer N. Kraszewski, Robb Krumlauf, Tilo Kunath, Takahiro Kunisada, Robert Langer, Robert Lanza, Jean Pyo Lee, Shulamit Levenberg, S. Robert Levine, Haifan Lin, John W. Littlefield, Michael J. Lysaght, Fiona A. Mack, Terry Magnuson, Anna Malashicheva, Ofer Mandelboim, Nancy R. Manley, Klaus I. Matthaei, Yoav Mayshar, John W. McDonald, Dame Anne McLaren, Jill McMahon, Alexander Meissner, Harald von Melchner, Douglas A. Melton, Nathan Montgomery, Mary Tyler Moore, Tsutomu Motohashi, Franz-Josef Mueller, Christine Mummery, Satomi Nishikawa, Shin-Ichi Nishikawa, Andras Nagy, Hitoshi Niwa, Hiromi Okuyama, Jitka Ourednik, Vaclav Ourednik, Masahito Oyamada, Yumiko Oyamada, Virginia E. Papaioannou, Kook I. Park, Ethan S. Patterson, Larry T. Patterson, Alice Pébay, Martin F. Pera, Aitana Perea-Gomez, Anthony C.F. Perry, James N. Petitte, Blaine W. Phillips, S. Steven Potter, Arti K. Rai, Christopher Reeve, Benjamin Reubinoff, Janet Rossant, Michael Rubart, Pierre Savatier, Hans Schöler, Cordula Schulz, Nikolaus Schultz, Michael J. Shamblott, Richard L. Sidman, M. Celeste Simon, Evan Y. Snyder, A. Francis Stewart, Lorenz Studer, Azim Surani, Tetsuro Takamatsu, Yang D. Teng, Irma Thesleff, James A. Thomson, David Tosh, Paul Trainor, Alan O. Trounson, Motokazu Tsuneto, Mark Tummers, Edward Upjohn, George Varigos, Cécile Vernochet, Jay L. Vivian, Zhongde Wang, Gordon C. Weir, Susan E. Wert, Jeffrey A. Whitsett, J. David Wininger, Zhuoru Wu, Chunhui Xu, Toshiyuki Yamane, Jun Yamashita, Yukiko M. Yamashita, Hidetoshi Yamazaki, Laurie Zoloth, Thomas P. Zwaka, Robert Zweigerdt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5bc76f68389b95a274f8f5574cc9b15
https://doi.org/10.1016/b978-012436643-5/50000-6