Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Jason W Rosch"'
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011421 (2023)
Streptococcus pneumoniae is an opportunistic pathogen that colonizes the upper respiratory tract asymptomatically and, upon invasion, can lead to severe diseases including otitis media, sinusitis, meningitis, bacteremia, and pneumonia. One of the fir
Externí odkaz:
https://doaj.org/article/a28aba4729004c15b9f37bdad8bf9b9e
Autor:
Maryann P Platt, Yi-Han Lin, Trevor Penix, Rosana Wiscovitch-Russo, Isha Vashee, Chris A Mares, Jason W Rosch, Yanbao Yu, Norberto Gonzalez-Juarbe
Publikováno v:
PLoS Pathogens, Vol 18, Iss 12, p e1011020 (2022)
BackgroundFor almost a century, it has been recognized that influenza A virus (IAV) infection can promote the development of secondary bacterial infections (SBI) mainly caused by Streptococcus pneumoniae (Spn). Recent observations have shown that IAV
Externí odkaz:
https://doaj.org/article/4c54f3bcf0f04f56b4401bb0dc9b5395
Autor:
Zachary M Burcham, Carl J Schmidt, Jennifer L Pechal, Christopher P Brooks, Jason W Rosch, M Eric Benbow, Heather R Jordan
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213280 (2019)
Population-based public health data on antibiotic resistance gene carriage is poorly surveyed. Research of the human microbiome as an antibiotic resistance reservoir has primarily focused on gut associated microbial communities, but data have shown m
Externí odkaz:
https://doaj.org/article/b5bae2ceef9c47c5bc63850ad9f47707
Autor:
Jason W Rosch, Amy R Iverson, Jessica Humann, Beth Mann, Geli Gao, Peter Vogel, Michael Mina, Kyle A Murrah, Antonia C Perez, W Edward Swords, Elaine I Tuomanen, Jonathan A McCullers
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 1, Pp 141-154 (2013)
Abstract Acute otitis media (AOM) caused by Streptococcus pneumoniae remains one of the most common infectious diseases worldwide despite widespread vaccination. A major limitation of the currently licensed pneumococcal vaccines is the lack of effica
Externí odkaz:
https://doaj.org/article/de0ad90ef07e4977a24c94db68f79a84
Autor:
Haley Echlin, Matthew W Frank, Amy Iverson, Ti-Cheng Chang, Michael D L Johnson, Charles O Rock, Jason W Rosch
Publikováno v:
PLoS Pathogens, Vol 12, Iss 10, p e1005951 (2016)
The pneumococcus is one of the most prodigious producers of hydrogen peroxide amongst bacterial pathogens. Hydrogen peroxide production by the pneumococcus has been implicated in antibiotic synergism, competition between other bacterial colonizers of
Externí odkaz:
https://doaj.org/article/ffeece64e7d94d6f8aead0dd2553d91f
Autor:
Victoria A Meliopoulos, Lee-Ann Van de Velde, Nicholas C Van de Velde, Erik A Karlsson, Geoff Neale, Peter Vogel, Cliff Guy, Shalini Sharma, Susu Duan, Sherri L Surman, Bart G Jones, Michael D L Johnson, Catharine Bosio, Lisa Jolly, R Gisli Jenkins, Julia L Hurwitz, Jason W Rosch, Dean Sheppard, Paul G Thomas, Peter J Murray, Stacey Schultz-Cherry
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005804 (2016)
The healthy lung maintains a steady state of immune readiness to rapidly respond to injury from invaders. Integrins are important for setting the parameters of this resting state, particularly the epithelial-restricted αVβ6 integrin, which is upreg
Externí odkaz:
https://doaj.org/article/34b3f00131f54876a1d6645d45e12018
Autor:
Lindsey R Brown, Steven M Gunnell, Adam N Cassella, Lance E Keller, Lisa A Scherkenbach, Beth Mann, Matthew W Brown, Rebecca Hill, Nicholas C Fitzkee, Jason W Rosch, Elaine I Tuomanen, Justin A Thornton
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146785 (2016)
Across bacterial species, metal binding proteins can serve functions in pathogenesis in addition to regulating metal homeostasis. We have compared and contrasted the activities of zinc (Zn2+)-binding lipoproteins AdcA and AdcAII in the Streptococcus
Externí odkaz:
https://doaj.org/article/18f79d6ba8cb4e208105c3e00e09ee3e
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 3 (2013)
For bacterial pathogens whose sole environmental reservoir is the human host, the acquisition of essential nutrients, particularly transition metals, is a critical aspect of survival due to tight sequestration and limitation strategies deployed to cu
Externí odkaz:
https://doaj.org/article/aaa43d900e634894aee61624261c20fd
Autor:
Beth Mann, Tim van Opijnen, Jianmin Wang, Caroline Obert, Yong-Dong Wang, Robert Carter, Daniel J McGoldrick, Granger Ridout, Andrew Camilli, Elaine I Tuomanen, Jason W Rosch
Publikováno v:
PLoS Pathogens, Vol 8, Iss 7, p e1002788 (2012)
Small noncoding RNAs (sRNAs) play important roles in gene regulation in both prokaryotes and eukaryotes. Thus far, no sRNA has been assigned a definitive role in virulence in the major human pathogen Streptococcus pneumoniae. Based on the potential c
Externí odkaz:
https://doaj.org/article/b1f6e1760cbb44c5a08d464b17d027d8
Autor:
Daniel E. Kennedy II, Perceus Mody, Jean-Francois Gout, Wei Tan, Keun Seok Seo, Alicia K. Olivier, Jason W. Rosch, Justin A. Thornton
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Apoptosis of cells at the site of infection is a requirement for shutdown of inflammatory signaling, avoiding tissue damage, and preventing progression of sepsis. Puma+/+ and Puma-/- mice were challenged with TIGR4 strain pneumococcus and cytokines w
Externí odkaz:
https://doaj.org/article/393bb0a9aa2c4a2980f87ebaa51cbb8e