Zobrazeno 1 - 10
of 331
pro vyhledávání: '"Jason W Locasale"'
Autor:
Min Lu, Sydney M Sanderson, Amelia Zessin, Kathleen A Ashcraft, Lee W Jones, Mark W Dewhirst, Jason W Locasale, David S Hsu
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-11 (2018)
Abstract Background While self-reported exercise is associated with a reduction in the risk of recurrence in colorectal cancer, the molecular mechanisms underpinning this relationship are unknown. Furthermore, the effect of exercise on intratumoral m
Externí odkaz:
https://doaj.org/article/01d0b6a63e64401dba5239e083996f4c
Autor:
Annamarie E Allen, Jason W Locasale
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 2, Pp 1-2 (2021)
Abstract Plant‐based diets exclude or substantially limit the consumption of meat and animal products and are of growing interest to many due to their sustainability and health benefits (Eshel et al, 2016). Veganism is an extreme type of plant‐ba
Externí odkaz:
https://doaj.org/article/3cd86b728c254ccf8faa5fc29c80d341
Autor:
Linda V Sinclair, Andrew JM Howden, Alejandro Brenes, Laura Spinelli, Jens L Hukelmann, Andrew N Macintyre, Xiaojing Liu, Sarah Thomson, Peter M Taylor, Jeffrey C Rathmell, Jason W Locasale, Angus I Lamond, Doreen A Cantrell
Publikováno v:
eLife, Vol 8 (2019)
Immune activated T lymphocytes modulate the activity of key metabolic pathways to support the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell differentiation. The present study uses high resolution mass spect
Externí odkaz:
https://doaj.org/article/7d4cdb633ab44514a668ee05c272cae5
Autor:
Stephen Salerno, Mahya Mehrmohamadi, Maria V Liberti, Muting Wan, Martin T Wells, James G Booth, Jason W Locasale
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179530 (2017)
With the surge of interest in metabolism and the appreciation of its diverse roles in numerous biomedical contexts, the number of metabolomics studies using liquid chromatography coupled to mass spectrometry (LC-MS) approaches has increased dramatica
Externí odkaz:
https://doaj.org/article/224e438d036147e48fd9efa6b8d0fa46
Autor:
Ziwei Dai, Jason W Locasale
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 2, Pp 1-2 (2017)
Abstract Metabolic alterations including increased glycolysis are a common feature of many cancers. In their recent study, Lowengrub, Waterman, and colleagues (Lee et al, 2017) report a spatial pattern of glycolysis in solid tumors that occurs within
Externí odkaz:
https://doaj.org/article/58e833a8ba58405e814d57b9abf788a1
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0117131 (2015)
Rapid advances in mass spectrometry have allowed for estimates of absolute concentrations across entire proteomes, permitting the interrogation of many important biological questions. Here, we focus on a quantitative aspect of human cancer cell metab
Externí odkaz:
https://doaj.org/article/9a1b563372124f05a593eecc766537b1
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 11, p e1003958 (2014)
Fluxes are the central trait of metabolism and Kinetic Flux Profiling (KFP) is an effective method of measuring them. To generalize its applicability, we present an extension of the method that estimates the relative changes of fluxes using only rela
Externí odkaz:
https://doaj.org/article/4128790797ad4250a6054f6dcdad0add
Autor:
Alexander A Shestov, Xiaojing Liu, Zheng Ser, Ahmad A Cluntun, Yin P Hung, Lei Huang, Dongsung Kim, Anne Le, Gary Yellen, John G Albeck, Jason W Locasale
Publikováno v:
eLife, Vol 3 (2014)
Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype. We developed
Externí odkaz:
https://doaj.org/article/09752d52123f4c86b873c1d4c9ef379c
Publikováno v:
Frontiers in Oncology, Vol 2 (2012)
Cancer progression is accompanied by widespread transcriptional changes and metabolic alterations. Although it is widely accepted that the origin of cancer can be traced to the mutations that accumulate over time, relatively recent evidence favors a
Externí odkaz:
https://doaj.org/article/1fa98c4698b747b1a663c863bdf1fb9b
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6522 (2009)
Advances in mass spectrometry among other technologies have allowed for quantitative, reproducible, proteome-wide measurements of levels of phosphorylation as signals propagate through complex networks in response to external stimuli under different
Externí odkaz:
https://doaj.org/article/44d280b7bb2646a78d2351ae76851c0a