Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jason V. Gregory"'
Autor:
Jason V. Gregory, Padma Kadiyala, Robert Doherty, Melissa Cadena, Samer Habeel, Erkki Ruoslahti, Pedro R. Lowenstein, Maria G. Castro, Joerg Lahann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The lack of effective drug delivery strategies has impaired the therapeutic progress in the treatment of glioblastoma (GBM). Here, the authors engineer synthetic protein nanoparticle based on polymerized human serum albumin equipped with the cell-pen
Externí odkaz:
https://doaj.org/article/b30c04bdef1f4073bda6bbf46a097b78
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 2 (2021)
Glioblastoma is an aggressive brain tumor with poor prognosis. The brain is protected by the blood–brain barrier, which precludes transport of chemotherapeutics. We developed nanoparticles that achieve delivery of small-interfering RNA against Stat
Externí odkaz:
https://doaj.org/article/51820f4ffd744729aac7202e83fa3556
Autor:
Jacob S. Brenner, Daniel C. Pan, Jacob W. Myerson, Oscar A. Marcos-Contreras, Carlos H. Villa, Priyal Patel, Hugh Hekierski, Shampa Chatterjee, Jian-Qin Tao, Hamideh Parhiz, Kartik Bhamidipati, Thomas G. Uhler, Elizabeth D. Hood, Raisa Yu. Kiseleva, Vladimir S. Shuvaev, Tea Shuvaeva, Makan Khoshnejad, Ian Johnston, Jason V. Gregory, Joerg Lahann, Tao Wang, Edward Cantu, William M. Armstead, Samir Mitragotri, Vladimir Muzykantov
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Unwanted uptake in the liver and limited accumulation in target organs is a major obstacle to targeted drug delivery. Here, the authors report on the hitchhiking of nanocarriers on red blood cells and the targeted upstream delivery to different targe
Externí odkaz:
https://doaj.org/article/362e0eed733347a8aa0df110774ccc31
Autor:
Mahmoud S. Alghamri, Kaushik Banerjee, Anzar A. Mujeeb, Ava Mauser, Ayman Taher, Rohit Thalla, Brandon L. McClellan, Maria L. Varela, Svetlana M. Stamatovic, Gabriela Martinez-Revollar, Anuska V. Andjelkovic, Jason V. Gregory, Padma Kadiyala, Alexandra Calinescu, Jennifer A. Jiménez, April A. Apfelbaum, Elizabeth R. Lawlor, Stephen Carney, Andrea Comba, Syed Mohd Faisal, Marcus Barissi, Marta B. Edwards, Henry Appelman, Yilun Sun, Jingyao Gan, Rose Ackermann, Anna Schwendeman, Marianela Candolfi, Michael R. Olin, Joerg Lahann, Pedro R. Lowenstein, Maria G. Castro
Publikováno v:
ACS Nano
Glioblastoma (GBM) is an aggressive primary brain cancer; with a 5-year survival of ~5%. Challenges that hamper GBM therapeutic efficacy include: (i) tumor heterogeneity, (ii) treatment resistance, (iii) immunosuppressive tumor microenvironment (TME)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b753af4faafaed24e5ea318bc7ec661b
https://europepmc.org/articles/PMC9649873/
https://europepmc.org/articles/PMC9649873/
Autor:
Melissa Cadena, Erkki Ruoslahti, Robert Doherty, Padma Kadiyala, Maria G. Castro, Samer Habeel, Joerg Lahann, Jason V. Gregory, Pedro R. Lowenstein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Glioblastoma (GBM), the most aggressive form of brain cancer, has witnessed very little clinical progress over the last decades, in part, due to the absence of effective drug delivery strategies. Intravenous injection is the least invasive drug deliv
Autor:
Vincent M. Rotello, Laura T. Ferguson, Tea Shuvaeva, Nahal Habibi, Colin F. Greineder, David C. Luther, George S Worthen, Priyal Patel, Landis R. Walsh, Jacob W. Myerson, Oscar A. Marcos-Contreras, Jia Nong, Jichuan Wu, Hong-Ying Zhang, Liudmila L. Mazaleuskaya, Marco E Zamora, Joerg Lahann, Ian Johnston, Michael H Zaleski, Jason V. Gregory, Vladimir R. Muzykantov, Raisa Yu Kiseleva, Elizabeth D. Hood, Kathryn M Rubey, Samir Mitragotri, Jacob S. Brenner, Tilo Grosser, Yi-Wei Lee, Patrick M. Glassman
This study shows that the supramolecular arrangement of proteins in nanoparticle structures predicts nanoparticle accumulation in neutrophils in acute lung inflammation (ALI). We observed homing to inflamed lungs for a variety of nanoparticles with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de3c7e5e03827014748aaac9cf92e29
https://pub.uni-bielefeld.de/record/2965299
https://pub.uni-bielefeld.de/record/2965299
Autor:
Alexandra Calinescu, Rohit Thalla, Mahmoud S. Alghamri, Jennifer A. Jiménez, Maria Luisa Varela, Marta Edwards, Jason V. Gregory, Marcus Barissi, Padma Kadiyala, April A. Apfelbaum, Gabriela Martinez-Revollar, Pedro R. Lowenstein, Andrea Comba, Stephen Carney, Anzar A. Mujeeb, Maria G. Castro, Joerg Lahann, Svetlana M. Stamatovic, Ayman Taher, Brandon L. McClellan, Michael R. Olin, Syed M Faisal, Anuska Andjelkovic-Zochowska, Kaushik Banerjee, Elizabeth R Lawlor, Henry D. Appelman
Glioblastoma multiforme (GBM) is an aggressive primary brain tumor, with poor prognosis. Major obstacles hampering effective therapeutic response in GBM are tumor heterogeneity, high infiltration of immunosuppressive myeloid cells, and the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30efcd31438b70159553640e479fe886
https://doi.org/10.1101/2021.08.27.457953
https://doi.org/10.1101/2021.08.27.457953
Autor:
Fan Xie, Jason V. Gregory, Nicholas L. Abbott, Kenneth Cheng, Marco Bedolla-Pantoja, Kai Sun, Joerg Lahann, Young-Ki Kim, Christoph Hussal
Publikováno v:
Science. 362:804-808
Patterned fiber formation The ability of liquid crystalline materials to order spontaneously has driven many innovations, from display technologies to extremely tough polymer fibers. Cheng et al. exploited this preponderance toward long-range orderin
Publikováno v:
Molecular & Cellular Oncology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Glioblastoma is an aggressive brain tumor with poor prognosis. The brain is protected by the blood–brain barrier, which precludes transport of chemotherapeutics. We developed nanoparticles that achieve delivery of small-interfering RNA against Stat
Autor:
Bradley Plummer, Daniel F Quevedo, Jason V. Gregory, Rikako Miki, Sahar Rahmani, Tyler Brown, Joerg Lahann, Samir Mitragotri, Yazmin Hernandez, Nahal Habibi, Jeffery E. Raymond
Publikováno v:
Macromolecular rapid communications. 41(23)
Protein nanoparticles are a promising approach for nanotherapeutics, as proteins combine versatile chemical and biological function with controlled biodegradability. In this work, the development of an adaptable synthesis method is presented for synt