Výsledky vyhledávání - "Jason Tierney"

Design, synthesis, and structure–activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel cannabinoid CB1 receptor agonists

Autor: Grant Wishart, James Baker, Kazuya Yoshiizumi, Phillip M. Cowley, Mark York, Morag Ferguson, Glenn Walker, Takao Kiyoi, Jean E. Cottney, Jim Cairns, Petula McPhail, Fiona Jeremiah, Julia M. Adam, Jason Tierney, Andrea K. Houghton, Richard Morphy, Elizabeth Margaret Moir, Andrew Osprey

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:7327-7330

Bicyclic piperazine derivatives were synthesized as conformationally constrained analogs of N-alkyl piperazines and were found to be potent CB1 receptor agonists. The CB1 receptor agonist activity was dependent upon the absolute configuration of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fda2b173106078ac1cdfec6172f46ca0
https://doi.org/10.1016/j.bmcl.2010.10.061

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Solid Phase Organic Synthesis

Autor: Fiona McKerlie, Catherine McCusker, Bernard Wathey, Tanya Wildman, Jason Tierney

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :ix-xiv

Perkin 1 Abstracts: Solid Phase Organic Synthesis are a selection of significant papers published in the recent literature covering the broad area of Solid Phase Organic Synthesis (SPOS). The abstracts cover preparation of single compounds on solid s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d376e2bd662a437574d044e0ba46f775
https://doi.org/10.1039/b005971o

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The Impact of Microwave-Assisted Organic Chemistry on Drug Discovery

Autor: Jacob Westman, Jason Tierney, Pelle Lidström, Bernard Wathey

Publikováno v: ChemInform. 34

Microwave-assisted organic synthesis (MAOS) is rapidly becoming recognized as a valuable tool for easing some of the bottlenecks in the drug discovery process. This article outlines the basic principles behind the technology and summarizes the areas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34de7064eaa8b67a7156d8376b472761
https://doi.org/10.1002/chin.200312260

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