Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Jason T. Yustein"'
Autor:
Tajhal D. Patel, Sandra L. Grimm, Rupa S. Kanchi, Tanmay Gandhi, Amrit Koirala, Jason T. Yustein, Cristian Coarfa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Osteosarcoma is the most prevalent bone tumor in pediatric patients. Neoadjuvant chemotherapy has improved osteosarcoma patient survival, however the 5-year survival rate for localized osteosarcoma is 75% with a 30–50% recurrence rate. We,
Externí odkaz:
https://doaj.org/article/3d66ea6b725f45dba0ecec6c9390c625
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Sarcomas comprise between 10–15% of all pediatric malignancies. Osteosarcoma and Ewing sarcoma are the two most common pediatric bone tumors diagnosed in children and young adults. These tumors are commonly treated with surgery and/or radiation the
Externí odkaz:
https://doaj.org/article/6a5ae4eae1054e239f87be40f11f3d15
Autor:
Jose Thaiparambil, Jianrong Dong, Sandra L. Grimm, Dimuthu Perera, Chandra Shekar R. Ambati, Vasanta Putluri, Matthew J. Robertson, Tajhal D. Patel, Brandon Mistretta, Preethi H. Gunaratne, Min P. Kim, Jason T. Yustein, Nagireddy Putluri, Cristian Coarfa, Randa El‐Zein
Publikováno v:
Cancer Medicine, Vol 12, Iss 1, Pp 584-596 (2023)
Abstract Background Non‐small cell lung cancer (NSCLC) comprises the majority (~85%) of all lung tumors, with lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being the most frequently diagnosed histological subtypes. Multi‐modal omi
Externí odkaz:
https://doaj.org/article/446a9373295047ea962bd5f2c349b9b6
Autor:
Federica Giordano, Stefania Lenna, Gherardo Baudo, Riccardo Rampado, Matteo Massaro, Enrica De Rosa, April Ewing, Lyazat Kurenbekova, Marco Agostini, Jason T. Yustein, Francesca Taraballi
Publikováno v:
Cancer Nanotechnology, Vol 13, Iss 1, Pp 1-29 (2022)
Abstract Small-molecule tyrosine kinase inhibitors (TKIs) represent a potentially powerful approach to the treatment of osteosarcoma (OS). However, dose-limiting toxicity, therapeutic efficacy, and targeting specificity are significant barriers to th
Externí odkaz:
https://doaj.org/article/e83e63878afd44c580cc56f28baf503d
Autor:
David S. Shulman, Sarah B. Whittle, Didier Surdez, Kelly M. Bailey, Enrique de Álava, Jason T. Yustein, Adam Shlien, Masanori Hayashi, Alexander J. R. Bishop, Brian D. Crompton, Steven G. DuBois, Neerav Shukla, Patrick J. Leavey, Stephen L. Lessnick, Heinrich Kovar, Olivier Delattre, Thomas G. P. Grünewald, Cristina R. Antonescu, Ryan D. Roberts, Jeffrey A. Toretsky, Franck Tirode, Richard Gorlick, Katherine A. Janeway, Damon Reed, Elizabeth R. Lawlor, Patrick J. Grohar
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-11 (2022)
Abstract The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a quarter of patients with localized tumors and 60–80% of patien
Externí odkaz:
https://doaj.org/article/85d5d49a92054aefa68b0e44c262da64
Autor:
Bikesh K. Nirala, Tajhal D. Patel, Lyazat Kurenbekova, Ryan Shuck, Atreyi Dasgupta, Nino Rainusso, Cristian Coarfa, Jason T. Yustein
Publikováno v:
JCI Insight, Vol 8, Iss 13 (2023)
Osteosarcoma (OS) is the most common primary bone tumor of childhood. Approximately 20%–30% of OSs carry amplification of chromosome 8q24, which harbors the oncogene c-MYC and correlates with a poor prognosis. To understand the mechanisms that unde
Externí odkaz:
https://doaj.org/article/6c6a1f7a97ac4abc935a487e19557348
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Most osteosarcomas (OSs) develop from mesenchymal cells at the bone with abnormal growth in young patients. OS has an annual incidence of 3.4 per million people and a 60–70% 5-year surviving rate. About 20% of OS patients have metastasis a
Externí odkaz:
https://doaj.org/article/8f80f3ad62ea4f27a81ae857127f00ce
Autor:
Kengo Nakahata, Brian W. Simons, Enrico Pozzo, Ryan Shuck, Lyazat Kurenbekova, Zachary Prudowsky, Kshiti Dholakia, Cristian Coarfa, Tajhal D. Patel, Lawrence A. Donehower, Jason T. Yustein
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 2 (2022)
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, with overall long-term survival rates of ∼65-70%. Thus, additional molecular insights and representative models are critical for identifying and evaluating new treatment mod
Externí odkaz:
https://doaj.org/article/4f1254d0fac8461f809a57fff22f4858
Autor:
Lindsay C. Fadel, Ivany V. Patel, Jonathan Romero, I-Chih Tan, Shelli R. Kesler, Vikram Rao, S. A. Amali S. Subasinghe, Russell S. Ray, Jason T. Yustein, Matthew J. Allen, Brian W. Gibson, Justin J. Verlinden, Stanley Fayn, Nicole Ruggiero, Caitlyn Ortiz, Elizabeth Hipskind, Aaron Feng, Chijindu Iheanacho, Alex Wang, Robia G. Pautler
Publikováno v:
Biosensors, Vol 12, Iss 8, p 616 (2022)
Anesthesia is often used in preclinical imaging studies that incorporate mouse or rat models. However, multiple reports indicate that anesthesia has significant physiological impacts. Thus, there has been great interest in performing imaging studies
Externí odkaz:
https://doaj.org/article/e3590e0019ec447e8aabbbe88387c59e
Autor:
S. A. Amali S. Subasinghe, Robia G. Pautler, Md. Abul Hassan Samee, Jason T. Yustein, Matthew J. Allen
Publikováno v:
Biosensors, Vol 12, Iss 7, p 478 (2022)
Hypoxia in solid tumors is associated with poor prognosis, increased aggressiveness, and strong resistance to therapeutics, making accurate monitoring of hypoxia important. Several imaging modalities have been used to study hypoxia, but each modality
Externí odkaz:
https://doaj.org/article/970438b413ce4edeafe17fe702187c1f