Výsledky vyhledávání - "Jason T. Smith"

Akademický článek

In vivo quantitative FRET small animal imaging: Intensity versus lifetime-based FRET

Autor: Jason T. Smith, Nattawut Sinsuebphon, Alena Rudkouskaya, Xavier Michalet, Xavier Intes, Margarida Barroso

Publikováno v: Biophysical Reports, Vol 3, Iss 2, Pp 100110- (2023)

Förster resonance energy transfer (FRET) microscopy is used in numerous biophysical and biomedical applications to monitor inter- and intramolecular interactions and conformational changes in the 2–10 nm range. FRET is currently being extended to

Externí odkaz: https://doaj.org/article/486493d5dfb4401590016c5eb4302e57

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Akademický článek

Quantification of Trastuzumab–HER2 Engagement In Vitro and In Vivo

Autor: Alena Rudkouskaya, Jason T. Smith, Xavier Intes, Margarida Barroso

Publikováno v: Molecules, Vol 25, Iss 24, p 5976 (2020)

Human EGF Receptor 2 (HER2) is an important oncogene driving aggressive metastatic growth in up to 20% of breast cancer tumors. At the same time, it presents a target for passive immunotherapy such as trastuzumab (TZM). Although TZM has been widely u

Externí odkaz: https://doaj.org/article/0518cb86fd3d42469f5049c05d5a9922

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Micro-CT guided deep neural network for 3D reconstructions in widefield diffuse optical tomography

Autor: Navid Ibtehaj I. Nizam, Marien Ochoa, Jason T. Smith, Xavier R. Intes

Publikováno v: Multimodal Biomedical Imaging XVIII.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b369894c97b4f3560ffcfef52cd2f2cb
https://doi.org/10.1117/12.2650090

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Deep learning-based fusion of widefield diffuse optical tomography and micro-CT structural priors for accurate 3D reconstructions

Autor: Navid Ibtehaj Nizam, Marien Ochoa, Jason T. Smith, Xavier Intes

Publikováno v: Biomed Opt Express

Widefield illumination and detection strategies leveraging structured light have enabled fast and robust probing of tissue properties over large surface areas and volumes. However, when applied to diffuse optical tomography (DOT) applications, they s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04ca0baca55355af98cf0bb3796a263
https://europepmc.org/articles/PMC10026582/

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in vivoquantitative FRET small animal imaging: intensity versus lifetime-based FRET

Autor: Jason T. Smith, Nattawut Sinsuebphon, Alena Rudkouskaya, Xavier Michalet, Xavier Intes, Margarida Barroso

Publikováno v: bioRxiv

Förster Resonance Energy Transfer (FRET) microscopy is used in numerous biophysical and biomedical applications to monitor inter- and intramolecular interactions and conformational changes in the 2–10 nm range. FRET is currently being extended toi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dce46aed945f285706d11294694bf76d
https://doi.org/10.1101/2023.01.24.525411

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Computational macroscopic lifetime imaging and concentration unmixing of autofluorescence

Autor: Marien Ochoa, Jason T. Smith, Shan Gao, Xavier Intes

Publikováno v: J Biophotonics

Single-pixel computational imaging can leverage highly sensitive detectors that concurrently acquire data across spectral and temporal domains. For molecular imaging, such methodology enables to collect rich intensity and lifetime multiplexed fluores

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7815f97f60f3c2b5b49d399710c1851
https://doi.org/10.1002/jbio.202200133

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Monte Carlo-based data generation for efficient deep learning reconstruction of macroscopic diffuse optical tomography and topography applications

Autor: Navid Ibtehaj, Nizam, Marien, Ochoa, Jason T, Smith, Shan, Gao, Xavier, Intes

Publikováno v: Journal of Biomedical Optics. 27

Deep learning (DL) models are being increasingly developed to map sensor data to the image domain directly. However, DL methodologies are data-driven and require large and diverse data sets to provide robust and accurate image formation performances.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609b2c858798cbbe3e409a10b13caa02
https://doi.org/10.1117/1.jbo.27.8.083016

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Multiplexing drug-target engagement and metabolic imaging in HER2-positive tumor xenograft models

Autor: Alena Rudkouskaya, Jason T. Smith, Xavier R. Intes, Margarida Barroso

Publikováno v: Visualizing and Quantifying Drug Distribution in Tissue VI.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f2c617c624544f38507a15610c082d7
https://doi.org/10.1117/12.2607308

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Macroscopic Fluorescence Lifetime Imaging for Monitoring of Drug–Target Engagement

Autor: Marien Ochoa, Alena Rudkouskaya, Jason T. Smith, Xavier Intes, Margarida Barroso

Publikováno v: Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071618103

Precision medicine promises to improve therapeutic efficacy while reducing adverse effects, especially in oncology. However, despite great progresses in recent years, precision medicine for cancer treatment is not always part of routine care. Indeed,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9829be957c9b0b3e003814564eb4d5
https://europepmc.org/articles/PMC8941982/

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