Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jason T Schuman"'
Autor:
Jasper C Lin, Ruth A Ettinger, Jason T Schuman, Ai-Hong Zhang, Muhammad Wamiq-Adhami, Phuong-Cac T Nguyen, Shelley M Nakaya-Fletcher, Komal Puranik, Arthur R Thompson, Kathleen P Pratt
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0116577 (2015)
The development of neutralizing anti-factor VIII (FVIII) antibodies complicates the treatment of many hemophilia A patients. The C-terminal C2 domain is a particularly antigenic FVIII region. A crystal structure of recombinant FVIII-C2 bound to an Fa
Externí odkaz:
https://doaj.org/article/9f01ce1acfea4daca262cfb00998c208
Autor:
Delphine C. Malherbe, Constantinos Kurt Wibmer, Molati Nonyane, Jason Reed, D. Noah Sather, David A. Spencer, Jason T. Schuman, Biwei Guo, Shilpi Pandey, Harlan Robins, Byung Park, Deborah H. Fuller, Jonah B. Sacha, Penny L. Moore, Ann J. Hessell, Nancy L. Haigwood
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology, Vol 11 (2020)
We report here on HIV-1 immunization results in rabbits and macaques co-immunized with clade C gp160 DNA and gp140 trimeric envelope vaccines, a strategy similar to a recent clinical trial that showed improved speed and magnitude of humoral responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d952a0850e5bd0938d234c5b03954df4
https://doi.org/10.3389/fimmu.2020.00984
https://doi.org/10.3389/fimmu.2020.00984
Publikováno v:
Nucleic Acids Research
The Type I-F CRISPR-mediated (clustered regularly interspaced short palindromic repeats) adaptive immune system in Pseudomonas aeruginosa consists of two CRISPR loci and six CRISPR-associated (cas) genes. Foreign DNA surveillance is performed by a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a596be267826638ef8174b7dfe7abd9
http://doc.rero.ch/record/299651/files/gkv094.pdf
http://doc.rero.ch/record/299651/files/gkv094.pdf
Autor:
Nancy L. Haigwood, Harlan Robins, Andrew B. Stuart, Jason T. Schuman, Spyros A. Kalams, William F. Sutton, Shilpi Pandey, Byung Park, D. Noah Sather, Shelly J. Krebs, Delphine C. Malherbe, Ann J. Hessell, Franco Pissani, Biwei Guo
Publikováno v:
Journal of Virology. 88:12949-12967
Identifying characteristics of the human immunodeficiency virus type 1 (HIV-1) envelope that are effective in generating broad, protective antibodies remains a hurdle to HIV vaccine design. Emerging evidence of the development of broad and potent neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68eca38d67060facb439b0aebd4b5fa8
https://doi.org/10.1128/jvi.01812-14
https://doi.org/10.1128/jvi.01812-14
Autor:
Franco Pissani, Harlan Robins, Jason T. Schuman, Byung Park, Susan W. Barnett, Shelly J. Krebs, Nancy L. Haigwood, Delphine C. Malherbe
Publikováno v:
Vaccine. 32:507-513
Background Developing HIV envelope (Env) vaccine components that elicit durable and protective antibody responses is an urgent priority, given the results from the RV144 trial. Optimization of both the immunogens and vaccination strategies will be ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5722795d3b50ab462968d6cc68e6977
https://doi.org/10.1016/j.vaccine.2013.11.022
https://doi.org/10.1016/j.vaccine.2013.11.022
Autor:
Leonidas Stamatatos, Nicole A. Doria-Rose, Zane Kraft, Delphine C. Malherbe, Jean P. O'Malley, Jason T. Schuman, Susan W. Barnett, Wendy B. Puryear, Indresh K. Srivastava, Travis Beckett, Nancy L. Haigwood, Motomi Mori, Lynda Misher
Publikováno v:
Journal of Virology. 85:5262-5274
A major goal of human immunodeficiency virus type 1 (HIV-1) vaccine efforts is the design of Envelope (Env)-based immunogens effective at eliciting heterologous or broad neutralizing antibodies (NAbs). We hypothesized that programming the B-cell resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4000ebb5698e9625d777636f497a15dc
https://doi.org/10.1128/jvi.02419-10
https://doi.org/10.1128/jvi.02419-10
Publikováno v:
Nucleic Acids Research
MepR is a multidrug binding transcription regulator that represses expression of the Staphylococcus aureus multidrug efflux pump gene, mepA, as well as its own gene. MepR is induced by multiple cationic toxins, which are also substrates of MepA. In o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8f5a3ba12e6565859fdf4cc831ebae
https://doi.org/10.1093/nar/gkn1046
https://doi.org/10.1093/nar/gkn1046
Publikováno v:
The Journal of Peptide Research. 61:91-108
MUC1 mucin is a large transmembrane glycoprotein, the extracellular domain of which is formed by a repeating 20 amino acid sequence, GVTSAPDTRPAPGSTAPPAH. In normal breast epithelial cells, the extracellular domain is densely covered with highly bran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b2725815b72da57e5726daf88fa9a65
https://doi.org/10.1034/j.1399-3011.2003.00031.x
https://doi.org/10.1034/j.1399-3011.2003.00031.x
Autor:
Ronald A. Skurray, Jason T. Schuman, Melissa H. Brown, Richard G. Brennan, Maria A. Schumacher, Kate M. Peters
Publikováno v:
Biochemistry
The Staphylococcus aureus multidrug binding protein QacR binds to a broad spectrum of structurally dissimilar cationic, lipophilic drugs. Our previous structural analyses suggested that five QacR glutamic acid residues are critical for charge neutral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c494a8b703e9c0c8bf9c902cf1d06368
https://doi.org/10.1021/bi8008246
https://doi.org/10.1021/bi8008246
Autor:
Muhammad Wamiq-Adhami, Arthur R. Thompson, Jason T. Schuman, Jasper C. Lin, Phuong-Cac T. Nguyen, Kathleen P. Pratt, Ruth A. Ettinger, Ai-Hong Zhang, Shelley M. Nakaya-Fletcher, Komal Puranik
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 1, p e0116577 (2015)
PLoS ONE, Vol 10, Iss 1, p e0116577 (2015)
The development of neutralizing anti-factor VIII (FVIII) antibodies complicates the treatment of many hemophilia A patients. The C-terminal C2 domain is a particularly antigenic FVIII region. A crystal structure of recombinant FVIII-C2 bound to an Fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da765772ef34f264c218941385329158
http://europepmc.org/articles/PMC4304825
http://europepmc.org/articles/PMC4304825