Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Jason T Maynes"'
Autor:
Vikrant K Bhosle, Chunxiang Sun, Sajedabanu Patel, Tse Wing Winnie Ho, Johannes Westman, Dustin A Ammendolia, Fatemeh Mirshafiei Langari, Noah Fine, Nicole Toepfner, Zhubing Li, Manraj Sharma, Judah Glogauer, Mariana I Capurro, Nicola L Jones, Jason T Maynes, Warren L Lee, Michael Glogauer, Sergio Grinstein, Lisa A Robinson
Publikováno v:
eLife, Vol 12 (2023)
Neutrophils are essential for host defense against Staphylococcus aureus (S. aureus). The neuro-repellent, SLIT2, potently inhibits neutrophil chemotaxis, and might, therefore, be expected to impair antibacterial responses. We report here that, unexp
Externí odkaz:
https://doaj.org/article/eca449b6b5224e2b93b1b9e25a20e44b
Autor:
Nan Gai, Kazuyoshi Aoyama, David Faraoni, Neil M Goldenberg, David N Levin, Jason T Maynes, Mark J McVey, Farrukh Munshey, Asad Siddiqui, Timothy Switzer, Benjamin E Steinberg
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246427 (2021)
BackgroundThe COVID-19 pandemic has yielded an unprecedented quantity of new publications, contributing to an overwhelming quantity of information and leading to the rapid dissemination of less stringently validated information. Yet, a formal analysi
Externí odkaz:
https://doaj.org/article/c17b8df961c04714afab76ec2f822c4c
Autor:
Jiefei Tong, Jonathan R Krieger, Paul Taylor, Rick Bagshaw, Jae Kang, Swathi Jeedigunta, Leanne E Wybenga-Groot, Wen Zhang, Heba Badr, Shideh Mirhadi, Nhu-An Pham, Étienne Coyaud, Man Yu, Ming Li, Michael Cabanero, Brian Raught, Jason T Maynes, Cynthia Hawkins, Ming Sound Tsao, Michael F Moran
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0237981 (2020)
Serine hydroxymethyltransferase 2 (SHMT2) converts serine plus tetrahydrofolate (THF) into glycine plus methylene-THF and is upregulated at the protein level in lung and other cancers. In order to better understand the role of SHMT2 in cancer a model
Externí odkaz:
https://doaj.org/article/c7f34d407c984a35b79c0dc38739259f
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Many challenges remain in the preclinical evaluation, adjudication, and prioritization of novel compounds in therapeutic discovery pipelines. These obstacles are evident by the large number of candidate or lead compounds failing to reach clinical tri
Externí odkaz:
https://doaj.org/article/65c5d324d9924689aa56de6230529032
Autor:
Wenkun Dou, Manpreet Malhi, Qili Zhao, Li Wang, Zongjie Huang, Junhui Law, Na Liu, Craig A. Simmons, Jason T. Maynes, Yu Sun
Publikováno v:
Microsystems & Nanoengineering, Vol 8, Iss 1, Pp 1-22 (2022)
Abstract Emerging heart-on-a-chip platforms are promising approaches to establish cardiac cell/tissue models in vitro for research on cardiac physiology, disease modeling and drug cardiotoxicity as well as for therapeutic discovery. Challenges still
Externí odkaz:
https://doaj.org/article/b2912b925d9f4854b960c422a74ee37d
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Malhi et al. conduct a high-throughput screen to identify inhibitors of respiratory syncytial virus (RSV). They find that statins inhibit post-entry events in the replicative cycle of RSV through a combination of cholesterol and isoprenoid-mediated e
Externí odkaz:
https://doaj.org/article/d5e0a132508d4999b1c6de098318fb52
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The potential adverse impact of inhalational anesthetics on the developing brain was highlighted by the addition of a medication warning by the U.S. Food and Drug Administration for their use in the pediatric population. To investigate mecha
Externí odkaz:
https://doaj.org/article/abda3efc044a41fb952dc3d8d9f3073f
Autor:
Wenkun Dou, Abdelkader Daoud, Xin Chen, Tiancong Wang, Manpreet Malhi, Zheyuan Gong, Fatemeh Mirshafiei, Min Zhu, Guanqiao Shan, Xi Huang, Jason T. Maynes, Yu Sun
Publikováno v:
Nano Letters. 23:2321-2331
Autor:
Birgitt Gutbier, Xiaohui Jiang, Kristina Dietert, Carolin Ehrler, Jasmin Lienau, Paul Van Slyke, Harold Kim, Van C. Hoang, Jason T. Maynes, Daniel J. Dumont, Achim D. Gruber, Norbert Weissmann, Timothy J. Mitchell, Norbert Suttorp, Martin Witzenrath
Publikováno v:
Critical Care, Vol 21, Iss 1, Pp 1-12 (2017)
Abstract Background Community-acquired pneumonia (CAP) is a significant cause of morbidity and mortality worldwide. Despite effective antimicrobial therapy, CAP can induce pulmonary endothelial hyperpermeability resulting in life-threatening lung fai
Externí odkaz:
https://doaj.org/article/2bf0dc3bc5d244dca7926872831e2097
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology
Respiratory syncytial virus (RSV) is a leading cause of severe respiratory tract infections in children. To uncover new antiviral therapies, we developed a live cell-based high content screening approach for rapid identification of RSV inhibitors and