A global initiative to refine acute inhalation studies through the use of ‘evident toxicity’ as an endpoint : Towards adoption of the fixed concentration procedure

Autor: Ian Indans, Jason Smedley, Graham W. Horgan, Anne Braun, Terry Kenny, Gary Wnorowski, Paul Smith, Brian S. Anderson, Ian Ragan, Hajime Kojima, William S. Stokes, Fiona Sewell, Robert Guest, Ngaire Dennison, David Griffiths, Warren Casey, Pilar Prieto, Ton van Huygevoort, Kyuhong Lee, Tim Marczylo, Tom Holmes

Publikováno v: Regulatory Toxicology and Pharmacology
Regulatory Toxicology and Pharmacology, Elsevier, 2015, 73 (3), pp.770-779. ⟨10.1016/j.yrtph.2015.10.018⟩

Acute inhalation studies are conducted in animals as part of chemical hazard identification and characterisation, including for classification and labelling purposes. Current accepted methods use death as an endpoint (OECD TG403 and TG436), whereas t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77030a14b4dce07859ac827d19793736
https://hal-ineris.archives-ouvertes.fr/ineris-01855133