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pro vyhledávání: '"Jason Slingsby"'
Autor:
Susan M. Kingsman, Julia A. Sutton, Margaret Esapa, Toby Price, Dilair F. Baban, Jason Slingsby, Alan J. Kingsman, Andrew Slade
Publikováno v:
Human Gene Therapy. 11:1439-1451
A number of stable producer cell lines for high-titer Mo-MuLV vectors have been constructed. Development has previously centered on increasing end-point titers by producing maximal levels of Mo-MuLV Gag/Pol, envelope glycoproteins, and retroviral RNA
Autor:
Alan J. Kingsman, Hayley Spearman, Jason Slingsby, Margaret Esapa, Stuart Naylor, Andrew Slade, L Griffiths, Dilair Baban, Susan M. Kingsman, Mark Uden, Toby Price, O. Kan, S. Iqball
Publikováno v:
Cancer gene therapy. 8(7)
Human cytochrome P450 2B6 (CYP2B6) metabolizes the prodrug cyclophosphamide (CPA) to produce phosphoramide mustard that cross-links DNA leading to cell death. We have constructed a novel retroviral vector encoding CYP2B6 (designated “MetXia-P450”