Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jason Shoush"'
Autor:
Samantha B. Kemp, Noah Cheng, Nune Markosyan, Rina Sor, Il-Kyu Kim, Jill Hallin, Jason Shoush, Liz Quinones, Natalie V. Brown, Jared B. Bassett, Nikhil Joshi, Salina Yuan, Molly Smith, William P. Vostrejs, Kia Z. Perez-Vale, Benjamin Kahn, Feiyan Mo, Timothy R. Donahue, Caius G. Radu, Cynthia Clendenin, James G. Christensen, Robert H. Vonderheide, Ben Z. Stanger
Publikováno v:
Cancer Discovery. 13:298-311
Mutations in the KRAS oncogene are found in more than 90% of patients with pancreatic ductal adenocarcinoma (PDAC), with Gly-to-Asp mutations (KRASG12D) being the most common. Here, we tested the efficacy of a small-molecule KRASG12D inhibitor, MRTX1
Autor:
Ben Z. Stanger, Robert H. Vonderheide, James G. Christensen, Cynthia Clendenin, Caius G. Radu, Timothy R. Donahue, Feiyan Mo, Benjamin Kahn, Kia Z. Perez-Vale, William P. Vostrejs, Molly Smith, Salina Yuan, Nikhil Joshi, Jared B. Bassett, Natalie V. Brown, Liz Quinones, Jason Shoush, Jill Hallin, Il-Kyu Kim, Rina Sor, Nune Markosyan, Noah Cheng, Samantha B. Kemp
MRTX1133 selectively inhibits KRASG12D and downstream MAPK signaling in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39958610ccaffa414aa6c8d481568e7b
https://doi.org/10.1158/2159-8290.22541985
https://doi.org/10.1158/2159-8290.22541985
Autor:
Ben Z. Stanger, Robert H. Vonderheide, James G. Christensen, Cynthia Clendenin, Caius G. Radu, Timothy R. Donahue, Feiyan Mo, Benjamin Kahn, Kia Z. Perez-Vale, William P. Vostrejs, Molly Smith, Salina Yuan, Nikhil Joshi, Jared B. Bassett, Natalie V. Brown, Liz Quinones, Jason Shoush, Jill Hallin, Il-Kyu Kim, Rina Sor, Nune Markosyan, Noah Cheng, Samantha B. Kemp
MRTX1133 is selective for KRASG12D in immunocompetent implantation tumor models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42fe79085aa5738ede795e475fcf6d8c
https://doi.org/10.1158/2159-8290.22541982.v1
https://doi.org/10.1158/2159-8290.22541982.v1
Autor:
Ben Z. Stanger, Robert H. Vonderheide, James G. Christensen, Cynthia Clendenin, Caius G. Radu, Timothy R. Donahue, Feiyan Mo, Benjamin Kahn, Kia Z. Perez-Vale, William P. Vostrejs, Molly Smith, Salina Yuan, Nikhil Joshi, Jared B. Bassett, Natalie V. Brown, Liz Quinones, Jason Shoush, Jill Hallin, Il-Kyu Kim, Rina Sor, Nune Markosyan, Noah Cheng, Samantha B. Kemp
MRTX1133 reduces metastatic burden in a tail vein model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac49f194634a9aeaf89338595bb83298
https://doi.org/10.1158/2159-8290.22541979.v1
https://doi.org/10.1158/2159-8290.22541979.v1
Autor:
Ben Z. Stanger, Robert H. Vonderheide, James G. Christensen, Cynthia Clendenin, Caius G. Radu, Timothy R. Donahue, Feiyan Mo, Benjamin Kahn, Kia Z. Perez-Vale, William P. Vostrejs, Molly Smith, Salina Yuan, Nikhil Joshi, Jared B. Bassett, Natalie V. Brown, Liz Quinones, Jason Shoush, Jill Hallin, Il-Kyu Kim, Rina Sor, Nune Markosyan, Noah Cheng, Samantha B. Kemp
Effects of MRTX1133 in KPC/Y and subcutaneous models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a732a77bbd6b4d15dc3927ab549d348
https://doi.org/10.1158/2159-8290.22541967.v1
https://doi.org/10.1158/2159-8290.22541967.v1
Autor:
Ben Z. Stanger, Robert H. Vonderheide, James G. Christensen, Cynthia Clendenin, Caius G. Radu, Timothy R. Donahue, Feiyan Mo, Benjamin Kahn, Kia Z. Perez-Vale, William P. Vostrejs, Molly Smith, Salina Yuan, Nikhil Joshi, Jared B. Bassett, Natalie V. Brown, Liz Quinones, Jason Shoush, Jill Hallin, Il-Kyu Kim, Rina Sor, Nune Markosyan, Noah Cheng, Samantha B. Kemp
MRTX1133 exerts in vivo effects early in treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2caa24a5f7386367637c0356e2d64f2
https://doi.org/10.1158/2159-8290.22541973.v1
https://doi.org/10.1158/2159-8290.22541973.v1
Autor:
Ben Z. Stanger, Robert H. Vonderheide, James G. Christensen, Cynthia Clendenin, Caius G. Radu, Timothy R. Donahue, Feiyan Mo, Benjamin Kahn, Kia Z. Perez-Vale, William P. Vostrejs, Molly Smith, Salina Yuan, Nikhil Joshi, Jared B. Bassett, Natalie V. Brown, Liz Quinones, Jason Shoush, Jill Hallin, Il-Kyu Kim, Rina Sor, Nune Markosyan, Noah Cheng, Samantha B. Kemp
Mutations in the KRAS oncogene are found in more than 90% of patients with pancreatic ductal adenocarcinoma (PDAC), with Gly-to-Asp mutations (KRASG12D) being the most common. Here, we tested the efficacy of a small-molecule KRASG12D inhibitor, MRTX1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e0d39f7922f1d6508710cd69827ec7
https://doi.org/10.1158/2159-8290.c.6549777
https://doi.org/10.1158/2159-8290.c.6549777
Autor:
Ben Z. Stanger, Robert H. Vonderheide, James G. Christensen, Cynthia Clendenin, Caius G. Radu, Timothy R. Donahue, Feiyan Mo, Benjamin Kahn, Kia Z. Perez-Vale, William P. Vostrejs, Molly Smith, Salina Yuan, Nikhil Joshi, Jared B. Bassett, Natalie V. Brown, Liz Quinones, Jason Shoush, Jill Hallin, Il-Kyu Kim, Rina Sor, Nune Markosyan, Noah Cheng, Samantha B. Kemp
KRASG12D inhibition alters the tumor immune microenvironment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a7afbfb1eadc3d2b6d4bd86368d034
https://doi.org/10.1158/2159-8290.22541970.v1
https://doi.org/10.1158/2159-8290.22541970.v1
Autor:
Ben Z. Stanger, Robert H. Vonderheide, James G. Christensen, Cynthia Clendenin, Caius G. Radu, Timothy R. Donahue, Feiyan Mo, Benjamin Kahn, Kia Z. Perez-Vale, William P. Vostrejs, Molly Smith, Salina Yuan, Nikhil Joshi, Jared B. Bassett, Natalie V. Brown, Liz Quinones, Jason Shoush, Jill Hallin, Il-Kyu Kim, Rina Sor, Nune Markosyan, Noah Cheng, Samantha B. Kemp
Supplementary Figures and Table with legend arranged in a single presentable package
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d184f87974f33470462a9dc0ab33eeae
https://doi.org/10.1158/2159-8290.22541964
https://doi.org/10.1158/2159-8290.22541964
Autor:
Ben Z. Stanger, Robert H. Vonderheide, James G. Christensen, Cynthia Clendenin, Caius G. Radu, Timothy R. Donahue, Feiyan Mo, Benjamin Kahn, Kia Z. Perez-Vale, William P. Vostrejs, Molly Smith, Salina Yuan, Nikhil Joshi, Jared B. Bassett, Natalie V. Brown, Liz Quinones, Jason Shoush, Jill Hallin, Il-Kyu Kim, Rina Sor, Nune Markosyan, Noah Cheng, Samantha B. Kemp
Antibody lists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96bb369f9351ab4045432211965152e9
https://doi.org/10.1158/2159-8290.22541961.v1
https://doi.org/10.1158/2159-8290.22541961.v1