Comparison of a mycobacterial phage assay to detect viable Mycobacterium avium subspecies paratuberculosis with standard diagnostic modalities in cattle with naturally infected Johne disease

Autor: Robert J. Greenstein, Liya Su, Irene R. Grant, Antonio C. G. Foddai, Amy Turner, Jason S. Nagati, Sheldon T. Brown, Judith R. Stabel

Publikováno v: Gut Pathogens, Vol 13, Iss 1, Pp 1-12 (2021)

Abstract Background Mycobacterium avium subspecies paratuberculosis (MAP), the cause of Johne disease, is a slow growing mycobacterium. Viable MAP detection is difficult, inconstant and time-consuming. The purpose of this study was to compare a rapid

Externí odkaz: https://doaj.org/article/bf1da685a8e74469aecd855909cf5ec6

Comparison of a mycobacterial phage assay to detect viable Mycobacterium avium subspecies paratuberculosis with standard diagnostic modalities in cattle with naturally infected Johne disease

Autor: Judith R. Stabel, Irene R. Grant, Sheldon T. Brown, Liya Su, Antonio Foddai, Robert J. Greenstein, Amy Turner, Jason S. Nagati

Publikováno v: Greenstein, R J, Su, L, Grant, I R, Foddai, A, Turner, A, Nagati, J S, Brown, S T & Stabel, J R 2021, ' Comparison of a mycobacterial phage assay to detect viable Mycobacterium avium subspecies paratuberculosis with standard diagnostic modalities in cattle with naturally infected Johne disease. ', Gut Pathogens, vol. 13, 30 . https://doi.org/10.1186/s13099-021-00425-5
Gut Pathogens, Vol 13, Iss 1, Pp 1-12 (2021)
Gut Pathogens

Background Mycobacterium avium subspecies paratuberculosis (MAP), the cause of Johne disease, is a slow growing mycobacterium. Viable MAP detection is difficult, inconstant and time-consuming. The purpose of this study was to compare a rapid phage/qP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5865aaec9908161810a29724e50d1ead
https://pure.qub.ac.uk/en/publications/comparison-of-a-mycobacterial-phage-assay-to-detect-viable-mycobacterium-avium-subspecies-paratuberculosis-with-standard-diagnostic-modalities-in-cattle-with-naturally-infected-johne-disease(6caea277-32e5-4190-bda3-451338807b4c).html

Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements

Autor: Philippe H. Kobeissy, Minh Q. Nguyen, Robert E. Hammer, Min Xu, Joseph A. Garcia, Sarah A. Comerford, Trent Garcia, Jason S. Nagati

Publikováno v: The Journal of Biological Chemistry

Besides contributing to anabolism, cellular metabolites serve as substrates or cofactors for enzymes and may also have signaling functions. Given these roles, multiple control mechanisms likely ensure fidelity of metabolite-generating enzymes. Acetat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b245e12bda11be33da72164d57a661
https://doi.org/10.1016/j.jbc.2021.101037

Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells

Autor: Joseph A. Garcia, Min Xu, Jason S. Nagati, Rui Chen

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 12, p e0190241 (2017)

Survival of cancer cells in the harsh tumor microenvironment, characterized by oxygen and glucose deprivation, requires rapid initiation of cytoprotective measures. Metabolites whose levels change during stress are ideal signaling cues, particularly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb115bc16c129a87bbca43827401154
http://europepmc.org/articles/PMC5744998

The Acetate/ACSS2 Switch Regulates HIF-2 Stress Signaling in the Tumor Cell Microenvironment

Autor: Min Xu, Joseph A. Garcia, Alok Das, Robert D. Gerard, Jason S. Nagati, Richard T. Hogg, Rui Chen

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0116515 (2015)
PLoS ONE

Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine acetyltransferase, Creb binding protein (CBP), and a specific deacetylase, Sirtuin 1 (SIRT1).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4f6876ff04b2d24e5b1aec40573c7b7
https://doi.org/10.1371/journal.pone.0116515