Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jason S. Huber"'
Autor:
Leslie M. Ogilvie, Brittany A. Edgett, Simon Gray, Sally Al-Mufty, Jason S. Huber, Keith R. Brunt, Jeremy A. Simpson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Cardiovascular and respiratory systems are anatomically and functionally linked; inspiration produces negative intrathoracic pressures that act on the heart and alter cardiac function. Inspiratory pressures increase with heart failure and ca
Externí odkaz:
https://doaj.org/article/f81faecfe49a4d2abbd96c1e0fd01c05
Autor:
Meghan C. Hughes, Sofhia V. Ramos, Patrick C. Turnbull, Irena A. Rebalka, Andrew Cao, Cynthia M.F. Monaco, Nina E. Varah, Brittany A. Edgett, Jason S. Huber, Peyman Tadi, Luca J. Delfinis, U. Schlattner, Jeremy A. Simpson, Thomas J. Hawke, Christopher G.R. Perry
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 3, Pp 643-661 (2019)
Abstract Background Muscle wasting and weakness in Duchenne muscular dystrophy (DMD) causes severe locomotor limitations and early death due in part to respiratory muscle failure. Given that current clinical practice focuses on treating secondary com
Externí odkaz:
https://doaj.org/article/45394ce7e817480d94ef81c89b2b57fc
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
A growing proportion of heart failure (HF) patients present with impairments in both ventricles. Experimental pressure-overload (i.e., transverse aortic constriction, TAC) induces left ventricle (LV) hypertrophy and failure, as well as right ventricl
Externí odkaz:
https://doaj.org/article/516eabf44e9e48a7a915ef2b33e7bf15
Autor:
Jason S. Huber, Brittany A. Edgett, Simon Gray, Keith R. Brunt, Jeremy A. Simpson, Leslie M. Ogilvie, Sally Al-Mufty
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Cardiovascular and respiratory systems are anatomically and functionally linked; inspiration produces negative intrathoracic pressures that act on the heart and alter cardiac function. Inspiratory pressures increase with heart failure and can exceed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6790468dcb81adce97c8cc23e59acf69
https://doaj.org/article/f81faecfe49a4d2abbd96c1e0fd01c05
https://doaj.org/article/f81faecfe49a4d2abbd96c1e0fd01c05
Autor:
Uwe Schlattner, Patrick C. Turnbull, Nazari Polidovitch, Peter H. Backx, Christopher G. R. Perry, Jason S. Huber, Jeremy A. Simpson, Meghan C. Hughes, Sofhia V. Ramos, Brittany A. Edgett
Publikováno v:
The Journal of Physiology
The Journal of Physiology, Wiley, 2019, ⟨10.1113/JP277306⟩
The Journal of Physiology, Wiley, 2019, ⟨10.1113/JP277306⟩
International audience; KEY POINTS:Ninety-eight per cent of patients with Duchenne muscular dystrophy (DMD) develop cardiomyopathy, with 40% developing heart failure. While increased propensity for mitochondrial induction of cell death has been obser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1272f767161a91abee12dee2b4fe08
https://doi.org/10.1113/jp277306
https://doi.org/10.1113/jp277306
Autor:
Keith R. Brunt, Leslie M. Ogilvie, Brittany A. Edgett, Sohrab Lutchmedial, Jason S. Huber, Jeremy A. Simpson, Hermann J. Eberl, Mathew J. Platt
Publikováno v:
Am J Physiol Heart Circ Physiol
Traditionally, the evaluation of cardiac function has focused on systolic function; however, there is a growing appreciation for the contribution of diastolic function to overall cardiac health. Given the emerging interest in evaluating diastolic fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530fe9b7c5523d969f3b485ad8277607
https://pubmed.ncbi.nlm.nih.gov/32216614
https://pubmed.ncbi.nlm.nih.gov/32216614
Autor:
Jason S. Huber, Paula M. Miotto, Graham P. Holloway, Luc J. C. van Loon, Cynthia M. F. Monaco, Jeremy A. Simpson
Publikováno v:
American Journal of Physiology-regulatory Integrative and Comparative Physiology, 315(2), R191-R204. American Physiological Society
Supplementation with dietary inorganic nitrate ([Formula: see text]) is increasingly recognized to confer cardioprotective effects in both healthy and clinical populations. While the mechanism(s) remains ambiguous, in skeletal muscle oral consumption
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e17818676ceb95ec33fe4741fc55396
https://doi.org/10.1152/ajpregu.00275.2017
https://doi.org/10.1152/ajpregu.00275.2017
Autor:
Keith R. Brunt, Jeremy A. Simpson, Nadya Romanova, Brittany A. Edgett, Melissa A. Allwood, Philip J. Millar, Ashley L. Eadie, Jason S. Huber
Publikováno v:
The Journal of Physiology. 596:3391-3410
Key points In the present study, we provide evidence for divergent physiological responses to moderate compared to severe hypoxia, addressing an important knowledge gap related to severity, duration and after-effects of hypoxia encountered in cardiop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5110bc730e11adc544e0bf453cb175b1
https://doi.org/10.1113/jp275945
https://doi.org/10.1113/jp275945
Autor:
Kaitlyn M. J. H. Dennis, Eric A.F. Herbst, Jacy M. Houad, Laelie A. Snook, Sabina Paglialunga, Pierre-Andre Barbeau, Graham P. Holloway, Jason S. Huber, Jeremy A. Simpson
Publikováno v:
The Journal of physiologyReferences. 598(4)
Key points Although the role of TBC1D1 within the heart remains unknown, expression of TBC1D1 increases in the left ventricle following an acute infarction, suggesting a biological importance within this tissue. We investigated the mechanistic role o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9706500b2d5bb5a32f996f48a24ee2d
https://pubmed.ncbi.nlm.nih.gov/31845331
https://pubmed.ncbi.nlm.nih.gov/31845331
Autor:
Jason S. Huber, Andrew J. Foster, Jordan M. Klaiman, Jeremy A. Simpson, Mathew J. Platt, Todd E. Gillis, Melissa Y Corso
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 310:H572-H586
Dyspnea and reduced exercise capacity, caused, in part, by respiratory muscle dysfunction, are common symptoms in patients with heart failure (HF). However, the etiology of diaphragmatic dysfunction has not been identified. To investigate the effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ca4b3abedbfc20aefc59eeab350f6d
https://doi.org/10.1152/ajpheart.00773.2015
https://doi.org/10.1152/ajpheart.00773.2015