Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jason S. Fender"'
Autor:
Varun Rawat, Clifford L. Eastman, Radhika Amaradhi, Avijit Banik, Jason S. Fender, Raymond J. Dingledine, Raimondo D’Ambrosio, Thota Ganesh
Publikováno v:
ACS Pharmacology & Translational Science. 6:128-138
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 379(3)
Mounting evidence suggests the synaptic vesicle glycoprotein 2A (SV2A) targeted by levetiracetam may contribute to epileptogenesis. Levetiracetam has shown anti-inflammatory, antioxidant, neuroprotective, and possible antiepileptogenic effects in bra
Autor:
Steven M. Rothman, Derek R. Verley, John W. Miller, Jeffrey G. Ojemann, Clifford L. Eastman, Hui Wen Wilkerson, Felix Darvas, Federico M. Farin, Nancy R. Temkin, Jason S. Fender, Raimondo D'Ambrosio, Matthew D. Smyth
Publikováno v:
Annals of Neurology. 73:199-209
Objective Post-traumatic epilepsy is prevalent, often difficult to manage, and currently cannot be prevented. Although cooling is broadly neuroprotective, cooling-induced prevention of chronic spontaneous recurrent seizures has never been demonstrate
Autor:
David W. Skyrud, Aaron D. Williams, Lindsay N. Warner, Nicholas P. Poolos, Jason S. Fender, Raimondo D'Ambrosio, Yusha Liu, Sangwook Jung, Tina Y. Tai, John F. Neumaier, Francis A. Concepcion, Terrance D. Jones
Publikováno v:
Neuroscience. 349
Several phosphorylation signaling pathways have been implicated in the pathogenesis of epilepsy arising from both genetic causes and acquired insults to the brain. Identification of dysfunctional signaling pathways in epilepsy may provide novel targe
Autor:
Clifford L. Eastman, Derek R. Verley, Tessandra Stewart, Jason S. Fender, Peter A. Groblewski, David G. Cook, Raimondo D'Ambrosio
Publikováno v:
Journal of Neurophysiology. 104:3345-3360
Astrocytic inwardly rectifying K+ currents ( IKIR) have an important role in extracellular K+ homeostasis, which influences neuronal excitability, and serum extravasation has been linked to impaired KIR-mediated K+ buffering and chronic hyperexcitabi
Autor:
Giulia Curia, Clifford L. Eastman, Derek R. Verley, Tessandra Stewart, Jason S. Fender, Raimondo D'Ambrosio, Eytan Nov
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 336:779-790
Carisbamate (CRS) exhibits broad acute anticonvulsant activity in conventional anticonvulsant screens, genetic models of absence epilepsy and audiogenic seizures, and chronic spontaneous motor seizures arising after chemoconvulsant-induced status epi
Autor:
Jeffrey G. Ojemann, Puneet Gupta, John W. Miller, Ramon Diaz-Arrastia, Clifford L. Eastman, Aaron H. Sheerin, Shahin Hakimian, Jason S. Fender, Raimondo D'Ambrosio, Derek R. Verley, Tessandra Stewart
Publikováno v:
Brain
Experimental animals’ seizures are often defined arbitrarily based on duration, which may lead to misjudgement of the syndrome and failure to develop a cure. We employed a functional definition of seizures based on the clinical practice of observin
Conventionally developed antiseizure drugs fail to control epileptic seizures in about 30% of patients, and no treatment prevents epilepsy. New etiologically realistic, syndrome-specific epilepsy models are expected to identify better treatments by c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb25d796dfb73d56642d30788b95da3a
https://europepmc.org/articles/PMC4327986/
https://europepmc.org/articles/PMC4327986/
Autor:
Jeffrey G. Ojemann, John W. Miller, Jason S. Fender, Raimondo D'Ambrosio, Giulia Curia, Michael R. Levitt
Human posttraumatic epilepsy (PTE) is highly heterogeneous, ranging from mild remitting to progressive disabling forms. PTE results in simple partial, complex partial, and secondarily generalized seizures with a wide spectrum of durations and semiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddcb864d1ec35b0378945b7bac3a6e09
https://hdl.handle.net/11380/1065105
https://hdl.handle.net/11380/1065105
Publikováno v:
Experimental neurology. 224(2)
The use of electrocorticography (ECoG) with etiologically realistic epilepsy models promises to facilitate the discovery of better anti-epileptic drugs (AEDs). However, this novel approach is labor intensive, and must be optimized. To this end, we em