Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jason S. Cronin"'
Autor:
Moher Eric D, John Allan Rieck, Richard D. Miller, Tracy K. Ditsworth, David A. Hay, Sandra S. K. Borders, Mindy B. Forst, Richard C. Hoying, and Duane A. Pierson, Joseph A. Turpin, Varie David Lee, Ryan J. Linder, Jason S. Cronin, David D. Anderson, and Jacob R. Remacle, Molly D. Brady, Hoard David W, Paul N. Dodson, Christopher A. Beck
Publikováno v:
Organic Process Research & Development. 11:546-559
A pilot-plant scale desymmetrization of the cyclic meso-epoxide 4b, using a chiral lithium amide prepared from symmetrical diamine 17, was designed and implemented to provide allylic alcohol 3b in high yield and greater than 99% ee. This chiral alcoh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f53e1e122ffede3fb8c73298de6793ee
https://doi.org/10.1021/op060225f
https://doi.org/10.1021/op060225f
Autor:
Michael E. LeTourneau, Gregory A. Stephenson, Bruce E. Parker, Lisa M. H. Zollars, Jason S. Cronin, Nicholas A. Magnus, James Abraham Aikins, John P. Schafer, Susan M. Reutzel-Edens, and Shella L. Tameze, Michael A. Staszak, Amy D. Hargis, William D. Diseroad
Publikováno v:
Organic Process Research & Development. 9:621-628
This article describes the development and optimization of chemical reactions and subsequent preparation of the API LY503430 under cGMPs to fund first human dose (FHD) clinical evaluation as a potential therapeutic agent for Parkinson's disease. Reas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d221a6e2a65d84e6e8be32a0a3d52af0
https://doi.org/10.1021/op0500741
https://doi.org/10.1021/op0500741
Publikováno v:
Organic Process Research & Development. 8:670-673
4-Methoxyphenylbutyric acid (2) is smoothly demethylated in 3 h at 180 °C when melted with pyridinium hydrochloride (Pyr·HCl), affording 4-hydroxyphenylbutyric acid (3), a key starting material for the preclinical candidate LY518674 (1). The adapta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d744140b2f2d1c4707b55603160c0d4
https://doi.org/10.1021/op0499526
https://doi.org/10.1021/op0499526
Autor:
John Brennan, Varie David Lee, Milton J. Zmijewski, John Allan Rieck, David A. Hay, Jason S. Cronin, Barbara Shreve Briggs
Publikováno v:
Tetrahedron Letters. 39:8405-8408
Cryptophycin fragment A ( 1 ) was prepared in high enantiomeric purity in 10 steps from ( R )-carvone. A stereoselective bioreduction of ( R )-carvone to neodihydrocarveol and a regioselective Baeyer-Villiger oxidation of cyclohexanone 8 with pertrif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::509efb990e6e9c782566f2430e70ddbf
https://doi.org/10.1016/s0040-4039(98)01784-5
https://doi.org/10.1016/s0040-4039(98)01784-5
Publikováno v:
Synthetic Communications. 26:3491-3494
A robust process for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine (1) is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb1cf67cf845612154711a04ab62c26b
https://doi.org/10.1080/00397919608003754
https://doi.org/10.1080/00397919608003754
Autor:
J. Jeffry Howbert, Karen Lynn Lobb, Francis Orerenyo Ginah, Hansen Guy Joe, Stuart L. Fort, Jason S. Cronin, Cho Sung-Yong Stephen, Philip Arthur Hipskind, Huff Bret Eugene
Publikováno v:
The Journal of Organic Chemistry. 60:7033-7036
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbdf4f778c7e6e6d40f174cf60720eb2
https://doi.org/10.1021/jo00126a069
https://doi.org/10.1021/jo00126a069
Publikováno v:
ChemInform. 27
A robust process for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine (1) is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23e499ca2c48a8afec76c558e7a20149
https://doi.org/10.1002/chin.199650178
https://doi.org/10.1002/chin.199650178
Autor:
Jason S. Cronin, David A. Hay, John Brennan, Varie David Lee, John Allan Rieck, Milton J. Zmijewski, Barbara Shreve Briggs
Publikováno v:
ChemInform. 30
Cryptophycin fragment A ( 1 ) was prepared in high enantiomeric purity in 10 steps from ( R )-carvone. A stereoselective bioreduction of ( R )-carvone to neodihydrocarveol and a regioselective Baeyer-Villiger oxidation of cyclohexanone 8 with pertrif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69f09a13700256af6a2da6d99751e6d1
https://doi.org/10.1002/chin.199906179
https://doi.org/10.1002/chin.199906179
Autor:
David L. Varie, Christopher Beck, Sandra K. Borders, Molly D. Brady, Jason S. Cronin, Tracy K. Ditsworth, David A. Hay, David W. Hoard, Richard C. Hoying, Ryan J. Linder, Richard D. Miller, Eric D. Moher, Jacob R. Remacle, John A. Rieck, David D. Anderson, Paul N. Dodson, Mindy B. Forst, Duane A. Pierson, Joseph A. Turpin
Publikováno v:
Organic Process Research & Development; May2007, Vol. 11 Issue 3, p546-559, 14p