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pro vyhledávání: '"Jason S Rawlings"'
Autor:
Jason S. Rawlings
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Immunology is a rapidly advancing and expanding field that is regularly highlighted in the lay media, whether it be checkpoint blockade immunotherapy winning the Nobel Prize, CAR-T cells in the treatment of cancer, or the latest anti-inflammatory/imm
Externí odkaz:
https://doaj.org/article/9a24f9aff2de48e69322ed58394bc8e1
Autor:
Jennifer R. Funsten, Taylor Y. Mitchell, Hayley E. Swatzel, Jason S. Rawlings, Tia A. Scott, Molly C. Shields, Audrey S. Ward, Sarah M. Eikenbusch, Kellie N. Bingham, Jenna L. Meredith, Megan L. Hanna, Keny O. Murillo Brizuela
Publikováno v:
Cellular immunology. 347
The clonal proliferation of antigen-specific T cells during an immune response critically depends on the differential response to growth factors, such as IL-2. While activated T cells proliferate robustly in response to IL-2 stimulation, naive (quies
Publikováno v:
The Journal of Immunology. 204:151.3-151.3
During an immune response, αβ T cells undergo a dramatic change in chromatin configuration, from a very condensed organization seen in naïve cells to a decondensed state in activated cells. It has previously been demonstrated that this change in c
Publikováno v:
The Journal of Immunology. 204:78.5-78.5
The phosphatidylinositol-3-kinase (PI3K) pathway is of significant interest due to its ability to regulate cell proliferation, growth, and migration in numerous contexts including in T cells. Furthermore, gain-of-function mutations in PI3K can lead t
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(14)
The phosphatidylinositol-3-kinase (PI3K) pathway regulates cellular metabolism and is upregulated in many cancers, making it an attractive chemotherapeutic target. Wortmannin is a potent inhibitor of PI3K; however, its potential as a chemotherapeutic
Autor:
Jason S. Rawlings
T lymphocytes (T cells) comprise a critical component of the immune system charged with diverse functions during an immune response. As a function of maturation in the thymus, T cells become quiescent and remain so until they participate in an immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83fba1808abebcb4f02f6a6b3adc2122
https://doi.org/10.1016/bs.apcsb.2016.08.001
https://doi.org/10.1016/bs.apcsb.2016.08.001
Publikováno v:
The EMBO Journal. 30:263-276
Naive T cells encountering their cognate antigen become activated and acquire the ability to proliferate in response to cytokines. Stat5 is an essential component in this response. We demonstrate that Stat5 cannot access DNA in naive T cells and acqu
Publikováno v:
Journal of Visualized Experiments : JoVE
During a proper immune response, quiescent T cells become activated upon antigen presentation to their antigen-specific T cell receptor. This leads to clonal proliferation of only those T cells that bear a receptor that recognizes the antigen. Chroma
Autor:
Jason S Rawlings, Jen Funsten, Keny Murillo Brizuela, Kellie Bingham, Megan Lee, Taylor Mitchell, Jenna Meredith
Publikováno v:
The Journal of Immunology. 198:124.1-124.1
A proper immune response is hallmarked by the activation and clonal proliferation of antigen specific T cells. Antigen presentation to the T cell receptor (TCR) leads to the production of two signaling molecules, IP3 and DAG. While IP3 induces calciu
Publikováno v:
The Journal of Immunology. 198:124.2-124.2
It has previously been demonstrated that chromatin decondensation is required for αβ T cell proliferation. B cells, γδ T cells, and Natural Killer cells share the same lineage as αβ T cells, originating from hematopoietic stem cells and a commo