Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Jason S King"'
Autor:
Israel Kiiza Njovu, Pauline Petra Nalumaga, Lucas Ampaire, Edwin Nuwagira, James Mwesigye, Benson Musinguzi, Kennedy Kassaza, Kabanda Taseera, James Kiguli Mukasa, Joel Bazira, Jacob Stanley Iramiot, Andrew Baguma, Felix Bongomin, Richard Kwizera, Beatrice Achan, Michael J Cox, Jason S King, Robin May, Elizabeth R Ballou, Herbert Itabangi
Publikováno v:
JMIR Research Protocols, Vol 12, p e48014 (2023)
BackgroundFungal-bacterial cocolonization and coinfections pose an emerging challenge among patients suspected of having pulmonary tuberculosis (PTB); however, the underlying pathogenic mechanisms and microbiome interactions are poorly understood. Un
Externí odkaz:
https://doaj.org/article/fa0c2c8e627a4ba6a4ab13720d7fa50c
Autor:
Catherine M Buckley, Victoria L Heath, Aurélie Guého, Cristina Bosmani, Paulina Knobloch, Phumzile Sikakana, Nicolas Personnic, Stephen K Dove, Robert H Michell, Roger Meier, Hubert Hilbi, Thierry Soldati, Robert H Insall, Jason S King
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007551 (2019)
By engulfing potentially harmful microbes, professional phagocytes are continually at risk from intracellular pathogens. To avoid becoming infected, the host must kill pathogens in the phagosome before they can escape or establish a survival niche. H
Externí odkaz:
https://doaj.org/article/1c14a090b71c476d9af92603e842ac01
Autor:
Ana T López-Jiménez, Elena Cardenal-Muñoz, Florence Leuba, Lilli Gerstenmaier, Caroline Barisch, Monica Hagedorn, Jason S King, Thierry Soldati
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007501 (2018)
Phagocytic cells capture and kill most invader microbes within the bactericidal phagosome, but some pathogens subvert killing by damaging the compartment and escaping to the cytosol. To prevent the leakage of pathogen virulence and host defence facto
Externí odkaz:
https://doaj.org/article/38e2e813fd284008adff457f66458ec9
Autor:
Elena Cardenal-Muñoz, Sonia Arafah, Ana Teresa López-Jiménez, Sébastien Kicka, Alexandra Falaise, Frauke Bach, Olivier Schaad, Jason S King, Monica Hagedorn, Thierry Soldati
Publikováno v:
PLoS Pathogens, Vol 13, Iss 4, p e1006344 (2017)
Autophagy is a eukaryotic catabolic process also participating in cell-autonomous defence. Infected host cells generate double-membrane autophagosomes that mature in autolysosomes to engulf, kill and digest cytoplasmic pathogens. However, several bac
Externí odkaz:
https://doaj.org/article/912a7fe7edb641a1b06bf0363c3ab118
Publikováno v:
Molecular biology of the cell.
Katnip is a highly conserved gene found mutated in some ciliopathies. In Dictyostelium, Katnip plays a general role in microtubule regulation and is required for lysosomal trafficking and digestion of autophagosomes and phagosomes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59d0eb695ab6f98893d363d6619ea14
https://pubmed.ncbi.nlm.nih.gov/36598819
https://pubmed.ncbi.nlm.nih.gov/36598819
Autor:
Judith E. Lutton, Helena L. E. Coker, Peggy Paschke, Christopher J. Munn, Jason S. King, Till Bretschneider, Robert R. Kay
Macropinocytosis is a conserved endocytic process where cells take up medium into micron-sized vesicles. InDictyostelium, macropinocytic cups form around domains of PIP3 in the plasma membrane and extend by actin polymerization. Using lattice light-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::610a803af9e5e9e37885863d2952b527
https://doi.org/10.1101/2022.10.07.511330
https://doi.org/10.1101/2022.10.07.511330
Autor:
James H. Vines, Catherine M. Buckley, Hannes Maib, Aurelie Gueho, Thierry Soldati, David Murray, Jason S. King
Phosphoinositide signalling lipids (PIPs) are key regulators of membrane identity and vesicle trafficking. Of these, PI(3,5)P2 is one of the least understood, despite key roles in many endocytic pathways including phagocytosis and macropinocytosis. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7be4217a38a81aa09a023701c20c0eab
https://doi.org/10.1101/2022.09.19.508510
https://doi.org/10.1101/2022.09.19.508510
Autor:
Robert R, Kay, Josiah, Lutton, Helena, Coker, Peggy, Paschke, Jason S, King, Till, Bretschneider
Publikováno v:
Sub-cellular biochemistry. 98
Macropinocytosis is a relatively unexplored form of large-scale endocytosis driven by the actin cytoskeleton. Dictyostelium amoebae form macropinosomes from cups extended from the plasma membrane, then digest their contents and absorb the nutrients i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fafa5a87bc725dddbefc0214e4997d7
https://pubmed.ncbi.nlm.nih.gov/35378702
https://pubmed.ncbi.nlm.nih.gov/35378702
The efficient delivery of lysosomes is essential for many cell functions, such as the degradation of unwanted intracellular components by autophagy and the killing and digestion of extracellular microbes within phagosomes. Using the amoeba Dictyostel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::354d74277af514b271f6ec21c6ef11a8
https://doi.org/10.1101/2022.02.22.481453
https://doi.org/10.1101/2022.02.22.481453
Publikováno v:
Subcellular Biochemistry ISBN: 9783030940034
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08f59f88f124ccb6917b5569fa7ae534
https://doi.org/10.1007/978-3-030-94004-1_3
https://doi.org/10.1007/978-3-030-94004-1_3