Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jason Roland"'
Autor:
Valeria Marrocco, Tuan Tran, Siying Zhu, Seung Hyuk Choi, Ana M. Gamo, Sijia Li, Qiangwei Fu, Marta Diez Cunado, Jason Roland, Mitch Hull, Van Nguyen-Tran, Sean Joseph, Arnab K. Chatterjee, Nikki Rogers, Matthew S. Tremblay, Weijun Shen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3983-3993 (2021)
Unfolded protein response (UPR) is a stress response that is specific to the endoplasmic reticulum (ER). UPR is activated upon accumulation of unfolded (or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the sy
Externí odkaz:
https://doaj.org/article/aea36db9b3d54981b52e7e072f989c15
Autor:
Zhihong Huang, Jennifer Shaffer, Badry Bursulaya, Anna Galkin, Rie Kikkawa, Yelena Sarkisova, Su Hua, John Tellew, Yang Yang, Paul Vincent Rucker, Robert Epple, Jiqing Jiang, Nanxin Li, Chianelli Donatella, Jason Roland, Lintong Li, Sergio Briones, Casey J. N. Mathison, Valentina Molteni, Jacqueline Kinyamu-Akunda, Mu-Yun Gao, John Nelson, Christian C. Lee, Yun Feng Xie, Shailaja Kasibhatla, Chun Li
Publikováno v:
ACS Med Chem Lett
[Image: see text] The selective inhibition of RET kinase as a treatment for relevant cancer types including lung adenocarcinoma has garnered considerable interest in recent years and prompted a variety of efforts toward the discovery of small-molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35f9c99597415f677d735f6ab409d8b
https://doi.org/10.1021/acsmedchemlett.1c00450
https://doi.org/10.1021/acsmedchemlett.1c00450
Autor:
Siying Zhu, Matthew S. Tremblay, Sean B. Joseph, Seung Hyuk Choi, Mitch Hull, Weijun Shen, Valeria Marrocco, Sijia Li, Marta Diez Cunado, Ana M. Gamo, Tuan Tran, Jason Roland, Arnab K. Chatterjee, Qiangwei Fu, Van Nguyen-Tran, Nikki Rogers
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3983-3993 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3983-3993 (2021)
Unfolded protein response (UPR) is a stress response that is specific to the endoplasmic reticulum (ER). UPR is activated upon accumulation of unfolded (or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c176a631b2a5bf8251732009aad27d09
http://europepmc.org/articles/PMC8727761
http://europepmc.org/articles/PMC8727761
Autor:
Badry Bursulaya, Nanxin Li, Yang Yang, Chianelli Donatella, John Nelson, Casey J. N. Mathison, Valentina Molteni, Sergio Briones, Chun Li, Shailaja Kasibhatla, Christian C. Lee, Jason Roland, Zhihong Huang, Jiqing Jiang, Anna Galkin, John Tellew, Robert Epple, Jacqueline Kinyamu-Akunda, Yelena Sarkisova, Mu-Yun Gao, Rie Kikkawa, Lintong Li, Su Hua, Paul Vincent Rucker, Jennifer Shaffer, Yun Feng Xie
Publikováno v:
ACS Medicinal Chemistry Letters. 11:558-565
RET (REarranged during Transfection) kinase gain-of-function aberrancies have been identified as potential oncogenic drivers in lung adenocarcinoma, along with several other cancer types, prompting the discovery and assessment of selective inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c095921d2621bc9f442ce1c2e02b661
https://doi.org/10.1021/acsmedchemlett.0c00015
https://doi.org/10.1021/acsmedchemlett.0c00015
Autor:
Sean B. Joseph, Paul Vincent Rucker, Peter McNamara, Michael Badman, Todd Groessl, Chianelli Donatella, Bo Liu, Alan Chu, Yugang Liu, Badry Bursulaya, H. Martin Seidel, Young Kim, John Nelson, Valentina Molteni, David C. Tully, David J Huang, Wendy Richmond, Andrew Phimister, Dingjiu Bao, Jane Wu, Thierry Schlama, Jason Roland, Eloy D. Hernandez, Bryan Laffitte, Jocelyn Zoll, Mahavir Prashad, Ignacio Sancho-Martinez, Robert Hill, Xiaodong Liu, James Schmeits
Publikováno v:
Journal of medicinal chemistry. 63(8)
Farnesoid X receptor (FXR) agonists are emerging as important potential therapeutics for the treatment of nonalcoholic steatohepatitis (NASH) patients, as they exert positive effects on multiple aspects of the disease. FXR agonists reduce lipid accum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308b3ff9affec6142819020e4a0d2b6c
https://pubmed.ncbi.nlm.nih.gov/31940200
https://pubmed.ncbi.nlm.nih.gov/31940200
Autor:
Tuan Anh Tran, Fabio Arturo Grieco, Nikki Rogers, Tyler D. Baguley, Matthew S. Tremblay, Sang Jun Lee, Weijun Shen, Arnab A.K. Chartterjee, Andrew To, Adam Henke, Decio L. Eizirik, Peter G. Schultz, Linlin Zhong, Shan Yu, Jason Roland, Sijia Li
Publikováno v:
British Journal of Pharmacology. 175:3470-3485
Background and purpose Beta cell apoptosis is a major feature of type 1 diabetes, and pro-inflammatory cytokines are key drivers of the deterioration of beta cell mass through induction of apoptosis. Mitochondrial stress plays a critical role in medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cdd4e2d583a66181d90424c56d6adaf
https://doi.org/10.1111/bph.14388
https://doi.org/10.1111/bph.14388
Autor:
Hanna T. Sjoberg, Mark J. Taylor, Bertrand L. Ndzeshang, William J. Sullivan, Mitchell V. Hull, Franziska Lenz, Wen Xiong, Case W. McNamara, Haelly M. Metuge, Nicolas Pionnier, Kelli Kuhen, Stefan J. Frohberger, Ashley K. Woods, Samuel Wanji, Laura Chappell, Frédéric Landmann, Xin-Jie Chu, Joseph D. Turner, Tayong Dizzle Bita Kwenti, Alain Debec, Achim Hoerauf, Bettina Dubben, Jason Roland, Matt S. Tremblay, Narcisse Victor T. Gandjui, Peter G. Schultz, Arnab K. Chatterjee, Jason Olejniczak, Baiyuan Yang, Patrick W. N. Chounna, Fanny Fri Fombad, Andrew Steven, Roohollah Kazem Shiroodi, Dominique Struever, Malina A. Bakowski, Sean B. Joseph, Renhe Liu, H. Michael Petrassi, Kerstin Mae Gagaring, John Archer, Emma A Murphy, Pamela M. White, Desmond N. Akumtoh, Valerine C. Chunda, Abdel Jelil Njouendou, Marc P. Hübner, Hui Guo, Alexandra Ehrens
Publikováno v:
Science Translational Medicine
Science Translational Medicine, American Association for the Advancement of Science, 2019, 11 (491), pp.eaav3523. ⟨10.1126/scitranslmed.aav3523⟩
Science Translational Medicine, American Association for the Advancement of Science, 2019, 11 (491), pp.eaav3523. ⟨10.1126/scitranslmed.aav3523⟩
Parasitic filarial nematodes cause debilitating infections in people in resource-limited countries. A clinically validated approach to eliminating worms uses a 4- to 6-week course of doxycycline that targetsWolbachia, a bacterial endosymbiont require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b7dd2acbde369889842c0450e10664
https://hal.archives-ouvertes.fr/hal-02365965
https://hal.archives-ouvertes.fr/hal-02365965
Dissociated sterol‐based liver X receptor agonists as therapeutics for chronic inflammatory diseases
Autor:
Matthew S. Tremblay, Jason Roland, Bo Cheng, Sijia Li, Evan D. Muse, Gustav Welzel, Shan Yu, Danling Wang, Arnab K. Chatterjee, Adam Henke, Christopher K. Glass
Publikováno v:
The FASEB Journal. 30:2570-2579
Liver X receptor (LXR), a nuclear hormone receptor, is an essential regulator of immune responses. Activation of LXR-mediated transcription by synthetic agonists, such as T0901317 and GW3965, attenuates progression of inflammatory disease in animal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218d589cb37dc866454a94dac3a5bda1
https://doi.org/10.1096/fj.201600244r
https://doi.org/10.1096/fj.201600244r
Autor:
Sotirios Tsimikas, Jeffrey G. McDonald, Christopher K. Glass, John Bahadorani, Jason Roland, Evan D. Muse, Shan Yu, Ty D. Troutman, Chantle Edillor, Jenhan Tao, Katherine A. Ozeki, Tamar R. Grossman, Adam Henke, Nathanael J. Spann, Bonne M. Thompson, Jason S. Seidman, Matthew S. Tremblay
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 20
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 20
Significance The beneficial effects of LXR-pathway activation have long been appreciated, but clinical application of synthetic LXR ligands has been limited by coactivation of SREBP1c and consequent hypertriglyceridemia. Natural LXR ligands such as d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6388165ceb70362085cad0970067dd10
https://pubmed.ncbi.nlm.nih.gov/29712848
https://pubmed.ncbi.nlm.nih.gov/29712848