Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Jason R. Rock"'
Autor:
Alexandra B. Ysasi, Anna E. Engler, Pushpinder Singh Bawa, Feiya Wang, Regan D. Conrad, Anthony K. Yeung, Jason R. Rock, Jennifer Beane-Ebel, Sarah A. Mazzilli, Ruth A. Franklin, Joseph P. Mizgerd, George J. Murphy
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110169- (2024)
Summary: Macrophages are critical for maintenance and repair of mucosal tissues. While functionally distinct subtypes of macrophage are known to have important roles in injury response and repair in the lungs, little is known about macrophages in the
Externí odkaz:
https://doaj.org/article/5b903bda8cf440d19e820e282f3de643
Autor:
Nils Korte, Zeki Ilkan, Claire L. Pearson, Thomas Pfeiffer, Prabhav Singhal, Jason R. Rock, Huma Sethi, Dipender Gill, David Attwell, Paolo Tammaro
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
Pericyte-mediated capillary constriction decreases cerebral blood flow in stroke after an occluded artery is unblocked. The determinants of pericyte tone are poorly understood. We show that a small rise in cytoplasmic Ca2+ concentration ([Ca2+]i) in
Externí odkaz:
https://doaj.org/article/3b8175d888bd4fc4971dd023142139a4
Isolation, Maintenance and Differentiation of Primary Tracheal Basal Cells from Adult Rhesus Macaque
Publikováno v:
Methods and Protocols, Vol 2, Iss 4, p 79 (2019)
In this report, we describe methodologies for the isolation and culture of primary rhesus macaque tracheal basal cells, their cryopreservation, long term storage and differentiation. These are comparable to state-of-the-art protocols that have been d
Externí odkaz:
https://doaj.org/article/e258e5677c9f403ba532ebafec8d4753
Autor:
Susanne M. Gollin, Jennifer R. Grandis, Vivian W. Lui, Xing Chen, Ann Marie Egloff, Raja S. Seethala, Rainer Schreiber, Karl Kunzelmann, Brian J. Henson, Brian D. Harfe, Jason R. Rock, Robert S. Edinger, Xin Huang, Carol Bertrand, Dong Xiao, Daniel J. Shiwarski, Umamaheswar Duvvuri
PDF file - 109K, TMEM16A expression can be rescued by expression of cDNA that is resistant to the effects of anti-TMEM16A shRNA. Quantitative RT-PCR was used to demonstrate that the knock-down of endogenous TMEM16A induced by shRNA can be rescued by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::770336805eb75d4ee51e9768977d0152
https://doi.org/10.1158/0008-5472.22391844.v1
https://doi.org/10.1158/0008-5472.22391844.v1
Autor:
Susanne M. Gollin, Jennifer R. Grandis, Vivian W. Lui, Xing Chen, Ann Marie Egloff, Raja S. Seethala, Rainer Schreiber, Karl Kunzelmann, Brian J. Henson, Brian D. Harfe, Jason R. Rock, Robert S. Edinger, Xin Huang, Carol Bertrand, Dong Xiao, Daniel J. Shiwarski, Umamaheswar Duvvuri
PDF file - 72K, Patient survival is not impacted by TMEM16A amplification status. Disease-specific and overall survival of the cohort of SCCHN patients was not significantly correlated with TMEM16A amplification (A, B).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060181eba672a10e59677fb156729b67
https://doi.org/10.1158/0008-5472.22391859
https://doi.org/10.1158/0008-5472.22391859
Autor:
Susanne M. Gollin, Jennifer R. Grandis, Vivian W. Lui, Xing Chen, Ann Marie Egloff, Raja S. Seethala, Rainer Schreiber, Karl Kunzelmann, Brian J. Henson, Brian D. Harfe, Jason R. Rock, Robert S. Edinger, Xin Huang, Carol Bertrand, Dong Xiao, Daniel J. Shiwarski, Umamaheswar Duvvuri
PDF file - 407K, TMEM16A overexpression promotes cell proliferation in HEK-293T cells. TMEM16A overexpression induced cellular proliferation (*P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810245f0d938b4427a3f81c7cd3f2cdc
https://doi.org/10.1158/0008-5472.22391853.v1
https://doi.org/10.1158/0008-5472.22391853.v1
Autor:
Susanne M. Gollin, Jennifer R. Grandis, Vivian W. Lui, Xing Chen, Ann Marie Egloff, Raja S. Seethala, Rainer Schreiber, Karl Kunzelmann, Brian J. Henson, Brian D. Harfe, Jason R. Rock, Robert S. Edinger, Xin Huang, Carol Bertrand, Dong Xiao, Daniel J. Shiwarski, Umamaheswar Duvvuri
PDF file - 109K, TMEM16A inhibition with T16A-inh01 (A01) alone or in combination with the MEK/ERK inhibitor UO126 leads to decreased tumor cell viability in vitro. UM-SCC1 and T24 cells were treated with increasing concentrations of A01. A dose depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d99cbab64d31993cac10bc4f1cb323c
https://doi.org/10.1158/0008-5472.22391841
https://doi.org/10.1158/0008-5472.22391841
Autor:
Susanne M. Gollin, Jennifer R. Grandis, Vivian W. Lui, Xing Chen, Ann Marie Egloff, Raja S. Seethala, Rainer Schreiber, Karl Kunzelmann, Brian J. Henson, Brian D. Harfe, Jason R. Rock, Robert S. Edinger, Xin Huang, Carol Bertrand, Dong Xiao, Daniel J. Shiwarski, Umamaheswar Duvvuri
PDF file - 101K, Cyclin D1 expression is reduced in the proliferating tissues derived from Tmem16a -/- mice when compared to wild-type littermates. Tissues harvested from Tmem16a -/- and wild-type mice were subjected to immunohistochemical staining f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884efc4f04c76bb473171c3180188069
https://doi.org/10.1158/0008-5472.22391847
https://doi.org/10.1158/0008-5472.22391847
Autor:
Susanne M. Gollin, Jennifer R. Grandis, Vivian W. Lui, Xing Chen, Ann Marie Egloff, Raja S. Seethala, Rainer Schreiber, Karl Kunzelmann, Brian J. Henson, Brian D. Harfe, Jason R. Rock, Robert S. Edinger, Xin Huang, Carol Bertrand, Dong Xiao, Daniel J. Shiwarski, Umamaheswar Duvvuri
PDF file - 97K, TMEM16A manipulation via shRNA mediated knock-down or overexpression leads to a measurable change in chloride conductance. Quantitative PCR demonstrates a significant decrease (~75%) in TMEM16A levels after shRNA treatment (A; mean
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ba3890dabe7f4ae08b91846ca088c2
https://doi.org/10.1158/0008-5472.22391856.v1
https://doi.org/10.1158/0008-5472.22391856.v1
Autor:
Susanne M. Gollin, Jennifer R. Grandis, Vivian W. Lui, Xing Chen, Ann Marie Egloff, Raja S. Seethala, Rainer Schreiber, Karl Kunzelmann, Brian J. Henson, Brian D. Harfe, Jason R. Rock, Robert S. Edinger, Xin Huang, Carol Bertrand, Dong Xiao, Daniel J. Shiwarski, Umamaheswar Duvvuri
PDF file - 139K, Anti-TMEM16A antibody recognizes endogeneous TMEM16A in immunohistochemistry. A rabbit polyclonal antibody was raised against a human TMEM16A epitope (as described in the Materials and Methods). This antibody was validated in immunoh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c216334b59bd33a406bf4c40c5797f1
https://doi.org/10.1158/0008-5472.22391862
https://doi.org/10.1158/0008-5472.22391862