Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jason R. Pugh"'
Autor:
Tabita Kreko-Pierce, Jason R. Pugh
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Duchenne muscular dystrophy (DMD) is generally regarded as a muscle-wasting disease. However, human patients and animal models of DMD also frequently display non-progressive cognitive deficits and high comorbidity with neurodevelopmental disorders, s
Externí odkaz:
https://doaj.org/article/ed0854fd3acf410886d7f7e6df75e7a6
Publikováno v:
J Neurosci
Duchenne muscular dystrophy (DMD), the most common form of childhood muscular dystrophy, is caused by mutations in the dystrophin gene. In addition to debilitating muscle degeneration, patients display a range of cognitive deficits thought to result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf3daf4e6eb736a7adf7f6f05f23daa
https://doi.org/10.1523/jneurosci.1256-21.2022
https://doi.org/10.1523/jneurosci.1256-21.2022
Publikováno v:
Journal of Neurophysiology. 121:1896-1905
Many synapses, including parallel fiber synapses in the cerebellum, express presynaptic GABAA receptors. However, reports of the functional consequences of presynaptic GABAA receptor activation are variable across synapses, from inhibition to enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5067c1234f8323e9051f05f44bb2a07
https://doi.org/10.1152/jn.00779.2018
https://doi.org/10.1152/jn.00779.2018
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Many neurons, including cerebellar granule cells, exhibit a tonic GABA current mediated by extrasynaptic GABAA receptors. This current is a critical regulator of firing and the target of many clinically relevant compounds. Using a combination of patc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7e98b477dc1d64306d07d6f62bc19b
https://doi.org/10.1038/s41598-019-53087-4
https://doi.org/10.1038/s41598-019-53087-4
Publikováno v:
Scientific Reports
Many neurons, including cerebellar granule cells, exhibit a tonic GABA current mediated by extrasynaptic GABAA receptors. This current is a critical regulator of firing and the target of many clinically relevant compounds. Using a combination of patc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2081c512a9d84178b2adbd4c2cff074f
https://pubmed.ncbi.nlm.nih.gov/31723152
https://pubmed.ncbi.nlm.nih.gov/31723152
Publikováno v:
J Physiol
Key points Inhibition of synaptic responses by activation of presynaptic cannabinoid type-1 (Cb1) receptors is reduced at parallel fibre synapses in the cerebellum following 4 Hz stimulation. Activation of adenylyl cyclase is necessary and sufficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b6c9ab14d3bd319ba6dd62811c093a
https://europepmc.org/articles/PMC8128044/
https://europepmc.org/articles/PMC8128044/
Autor:
Daniel C. Marcus, Donald G. Harbidge, Tabita Kreko-Pierce, Nina Boiko, James D. Stockand, Jason R. Pugh
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Unipolar brush cells (UBCs) are excitatory granular layer interneurons in the vestibulocerebellum. Here we assessed motor coordination and balance to investigate if deletion of acid-sensing ion channel 5 (Asic5), which is richly expressed in type II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25bcdaf3e5910a574b6780256b45a19
https://pubmed.ncbi.nlm.nih.gov/32034189
https://pubmed.ncbi.nlm.nih.gov/32034189
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::523859e49d0215ec1fdf557aaeff6c4e
https://doi.org/10.1096/fasebj.2019.33.1_supplement.824.13
https://doi.org/10.1096/fasebj.2019.33.1_supplement.824.13
Publikováno v:
J Neurophysiol
Many synapses, including parallel fiber synapses in the cerebellum, express presynaptic GABA(A) receptors. However, reports of the functional consequences of presynaptic GABA(A) receptor activation are variable across synapses, from inhibition to enh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::401181c98b4488e2b4a3f97dc9c6369a
https://pubmed.ncbi.nlm.nih.gov/30892973
https://pubmed.ncbi.nlm.nih.gov/30892973
Autor:
Jason R. Pugh, Rebecca D. Howell
Publikováno v:
The Journal of Physiology. 594:3651-3666
Key points Many excitatory synapses co-express presynaptic GABAA and GABAB receptors, despite their opposing actions on synaptic transmission. It is still unclear how co-activation of these receptors modulates synapse function. We measured presynapti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c831ec47c8ce8868c7bd187a278487b4
https://doi.org/10.1113/jp272124
https://doi.org/10.1113/jp272124