Výsledky vyhledávání - "Jason R. Burke"

Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases

Autor: Miriam Kaltenbach, Joseph M. Jez, Andrew T. Nelson, Joseph P. Noel, James J. La Clair, Dan S. Tawfik, Shina Caroline Lynn Kamerlin, Ryan N. Philippe, Anna Pabis, Jason R. Burke, George A. Cortina, Gordon V. Louie, Marianne E. Bowman, Katherine B. Woods

Chalcone isomerases are plant enzymes that perform enantioselective oxa-Michael cyclizations of 2′-hydroxy-chalcones into flavanones. An X-ray crystal structure of an enzyme-product complex and molecular dynamics simulations reveal an enzyme mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbbcbef548fd4456a82d360ea4fd6a4e
https://doi.org/10.1101/457440

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Strigolactone perception and deactivation by a hydrolase receptor DWARF14

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

The perception mechanism for the strigolactone (SL) class of plant hormones has been a subject of debate because their receptor, DWARF14 (D14), is an α/β-hydrolase that can cleave SLs. Here we show via time-course analyses of SL binding and hydroly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c883acfcda2680338dc2959a30f90fa4
https://pubmed.ncbi.nlm.nih.gov/31151745

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Evolution of chalcone isomerase from a noncatalytic ancestor

Autor: Joseph P. Noel, Miriam Kaltenbach, Avigayel Rabin, Jason R. Burke, Fabian S Munsberg, Anna Pabis, Dan S. Tawfik, Shina Caroline Lynn Kamerlin, Mirco Dindo

The emergence of catalysis in a noncatalytic protein scaffold is a rare, unexplored event. Chalcone isomerase (CHI), a key enzyme in plant flavonoid biosynthesis, is presumed to have evolved from a nonenzymatic ancestor related to the widely distribu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee648ecccccaa45b070161fc7640b30
https://hdl.handle.net/11391/1535994

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Evolution of chalcone isomerase from a non-catalytic ancestor

Autor: Anna Pabis, Joseph P. Noel, Miriam Kaltenbach, Avigayel Rabin, Jason R. Burke, Mirco Dindo, Fabian S Munsberg, Dan S. Tawfik, Shina Caroline Lynn Kamerlin

The emergence of catalysis in a non-catalytic protein scaffold is a rare, unexplored event. Chalcone isomerase (CHI), a key enzyme in plant flavonoid biosynthesis, is presumed to have evolved from a non-enzymatic ancestor related to the widely-distri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78dc4f12519e87ec75883f6f1a43ee86

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A Strategy for Direct Chemical Activation of the Retinoblastoma Protein

Autor: Jason R. Burke, Walter M. Bray, R. Scott Lokey, Cameron R. Pye, Seth M. Rubin, Elise R. Brown

Publikováno v: Pye, CR; Bray, WM; Brown, ER; Burke, JR; Lokey, RS; & Rubin, SM. (2016). A Strategy for Direct Chemical Activation of the Retinoblastoma Protein. ACS CHEMICAL BIOLOGY, 11(5), 1192-1197. doi: 10.1021/acschembio.6b00011. UC Santa Cruz: Retrieved from: http://www.escholarship.org/uc/item/2p8939v5
ACS chemical biology, vol 11, iss 5

The retinoblastoma (Rb) tumor suppressor protein negatively regulates cell proliferation by binding and inhibiting E2F transcription factors. Rb inactivation occurs in cancer cells upon cyclin-dependent kinase (Cdk) phosphorylation, which induces E2F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30ff79de1d227a78396c5e2908d7743
http://www.escholarship.org/uc/item/2p8939v5

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Publisher Correction: Evolution of chalcone isomerase from a noncatalytic ancestor

Autor: Miriam Kaltenbach, Joseph P. Noel, Jason R. Burke, Avigayel Rabin, Mirco Dindo, Fabian S Munsberg, Dan S. Tawfik, Shina Caroline Lynn Kamerlin, Anna Pabis

Publikováno v: Nature Chemical Biology. 14:988-988

In the version of this article originally published, the number for the equal contributions footnote was missing for Miriam Kaltenbach and Jason R. Burke in the author list. The error has been corrected in the PDF and print versions of this article.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e9114f4a5d1323aa78456f7a5ccc78d
https://doi.org/10.1038/s41589-018-0079-3

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Phosphorylation-induced Conformational Changes in the Retinoblastoma Protein Inhibit E2F Transactivation Domain Binding

Autor: Alison J. Deshong, Seth M. Rubin, Jason R. Burke, Jeffrey G. Pelton

Publikováno v: Journal of Biological Chemistry. 285:16286-16293

Inactivation of the retinoblastoma protein (Rb) through phosphorylation is an important step in promoting cell cycle progression, and hyperphosphorylated Rb is commonly found in tumors. Rb phosphorylation prevents its association with the E2F transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c34f905958ed3596eec1af803b3fd02
https://doi.org/10.1074/jbc.m110.108167

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Conflict in Cities and the Struggle for Modernity. Toward an Understanding of the Spatiality of the October Crisis

Autor: Jason R. Burke

Publikováno v: Cahiers de géographie du Québec. 53:335-349

À partir des années 1960, le Québec était prêt pour le changement. Au cours de cette décennie, deux visions pour un Québec moderne prirent forme et s’affrontèrent, culminant par ce qui est connu comme la rencontre la plus significative du C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4554cbda9232522a865ed7b2a445209
https://doi.org/10.7202/039184ar

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