Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jason R Thonhoff"'
Autor:
Luis Ojeda, Junling Gao, Kristopher G Hooten, Enyin Wang, Jason R Thonhoff, Tiffany J Dunn, Tianyan Gao, Ping Wu
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23414 (2011)
Fibroblast growth factor (FGF) and epidermal growth factor (EGF) are critical for the development of the nervous system. We previously discovered that FGF2 and EGF had opposite effects on motor neuron differentiation from human fetal neural stem cell
Externí odkaz:
https://doaj.org/article/51c33c28d2a849bc842f5bad86338f4a
Autor:
Jason R. Thonhoff, David R. Beers, Weihua Zhao, Alireza Faridar, Aaron Thome, Shixiang Wen, Aijun Zhang, Jinghong Wang, Stanley H. Appel
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
ObjectiveTo determine whether a combination therapy with abatacept (CTLA4-Ig) and interleukin-2 (IL-2) is safe and suppresses markers of oxidative stress, inflammation, and degeneration in ALS.MethodsIn this open-label study, four participants with A
Externí odkaz:
https://doaj.org/article/23b3a503a45b412f8431ba1083024eb8
Autor:
Alireza Faridar, Matthew Vasquez, Aaron D. Thome, Zheng Yin, Hui Xuan, Jing Hong Wang, Shixiang Wen, Xuping Li, Jason R. Thonhoff, Weihua Zhao, Hong Zhao, David R. Beers, Stephen T. C. Wong, Joseph C. Masdeu, Stanley H. Appel
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-13 (2022)
Abstract Background Regulatory T cells (Tregs) play a neuroprotective role by suppressing microglia and macrophage-mediated inflammation and modulating adaptive immune reactions. We previously documented that Treg immunomodulatory mechanisms are comp
Externí odkaz:
https://doaj.org/article/52b183fb078941b9b217ebdf26d36db7
Autor:
Aaron D. Thome, Alireza Faridar, David R. Beers, Jason R. Thonhoff, Weihua Zhao, Shixiang Wen, Belen Pascual, Joseph C. Masdeu, Stanley H. Appel
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-11 (2018)
Abstract Background Neuroinflammation is a hallmark of neurodegenerative disease and a significant component of the pathology of Alzheimer’s disease (AD). Patients present with extensive microgliosis along with elevated pro-inflammatory signaling i
Externí odkaz:
https://doaj.org/article/bd79f6c8e3194aba94dfcf283d6034b3
Autor:
David R. Beers, Jason R. Thonhoff, Alireza Faridar, Aaron D. Thome, Weihua Zhao, Shixiang Wen, Stanley H. Appel
Publikováno v:
Annals of Neurology. 92:195-200
Oxidative stress (OS) induces inflammation, which in turn exacerbates OS and the expression of acute phase proteins (APPs). Regulatory T lymphocyte (Treg) therapy was assessed for suppression of OS and APP responses in longitudinal serum samples from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ac563920558412204971ee242b7adc
https://doi.org/10.1002/ana.26375
https://doi.org/10.1002/ana.26375
Publikováno v:
Journal of Neuromuscular Diseases. 8:963-972
Background: Repeated neuromuscular electrical stimulation in type 1 Myotonic Dystrophy (DM1) has previously been shown to cause an increase in strength and a decrease in hyperexcitability of the tibialis anterior muscle. Objective: In this proof-of-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe928c3e84c3c16ba010ab05f4227df
https://doi.org/10.3233/jnd-210690
https://doi.org/10.3233/jnd-210690
Autor:
Aaron D. Thome, Jason R. Thonhoff, Weihua Zhao, Alireza Faridar, Jinghong Wang, David R. Beers, Stanley H. Appel
Publikováno v:
Frontiers in Immunology. 13
Extracellular vehicles (EVs) are efficient biomarkers of disease and participate in disease pathogenesis; however, their use as clinical therapies to modify disease outcomes remains to be determined. Cell-based immune therapies, including regulatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc276de24b553e4c63caaa2a81114388
https://doi.org/10.3389/fimmu.2022.875825
https://doi.org/10.3389/fimmu.2022.875825
Autor:
Junling Gao, Raymond J. Grill, Tiffany J. Dunn, Supinder Bedi, Javier Allende Labastida, Robert A. Hetz, Hasen Xue, Jason R. Thonhoff, Douglas S. DeWitt, Donald S. Prough, Charles S. Cox M.D., Ping Wu M.D., Ph.D.
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Neural stem cells (NSCs) promote recovery from brain trauma, but neuronal replacement is unlikely the sole underlying mechanism. We hypothesize that grafted NSCs enhance neural repair at least partially through modulating the host immune response aft
Externí odkaz:
https://doaj.org/article/7b3bf25a8f5b48fab8f6150528fa5b1b
Autor:
Alireza Faridar, Shixiang Wen, Jason R. Thonhoff, Aaron D. Thome, David R. Beers, Weihua Zhao, Jinghong Wang, Daniel Neal, Stanley H. Appel
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Amyotrophic lateral sclerosis (ALS) is a multifactorial, multisystem pro-inflammatory neuromuscular disorder compromising muscle function resulting in death. Neuroinflammation is known to accelerate disease progression and accentuate disease severity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbe9a68efd65e31e9ff9f343a678697
http://link.springer.com/article/10.1038/s41598-020-72247-5
http://link.springer.com/article/10.1038/s41598-020-72247-5
Autor:
Jason R. Thonhoff, James D. Berry, Eric A. Macklin, David R. Beers, Patricia A. Mendoza, Weihua Zhao, Aaron D. Thome, Fabio Triolo, James J. Moon, Sabrina Paganoni, Merit Cudkowicz, Stanley H. Appel
Publikováno v:
Neurology(R) neuroimmunologyneuroinflammation. 9(6)
Background and ObjectivesIn a phase 1 amyotrophic lateral sclerosis (ALS) study, autologous infusions of expanded regulatory T-lymphocytes (Tregs) combined with subcutaneous interleukin (IL)-2 were safe and well tolerated. Treg suppressive function i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78557dcc822c45f9fb85564c2df49ff4
https://pubmed.ncbi.nlm.nih.gov/36038262
https://pubmed.ncbi.nlm.nih.gov/36038262