Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jason R B Dyck"'
Autor:
Jody Groenendyk, Dukgyu Lee, Joanna Jung, Jason R B Dyck, Gary D Lopaschuk, Luis B Agellon, Marek Michalak
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159682 (2016)
Cardiac fibrosis attributed to excessive deposition of extracellular matrix proteins is a major cause of heart failure and death. Cardiac fibrosis is extremely difficult and challenging to treat in a clinical setting due to lack of understanding of m
Externí odkaz:
https://doaj.org/article/b52b9334faf44f2db81ced2cd4cdded6
Autor:
Cerina Dubois, Heidi Fernandes, Mu Lin, Karen J. B. Martins, Jason R. B. Dyck, Scott W. Klarenbach, Lawrence Richer, Ed Jess, John G. Hanlon, Elaine Hyshka, Dean T. Eurich
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Benzodiazepines are a class of medications that are being frequently prescribed in Canada but carry significant risk of harm. There has been increasing clinical interest on the potential “sparing effects” of medical cannabis a
Externí odkaz:
https://doaj.org/article/8b9cffff099f4203bb4e57cfbcfe7419
Autor:
Beshay N Zordoky, Miranda M Sung, Justin Ezekowitz, Rupasri Mandal, Beomsoo Han, Trent C Bjorndahl, Souhaila Bouatra, Todd Anderson, Gavin Y Oudit, David S Wishart, Jason R B Dyck, Alberta HEART
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124844 (2015)
Heart failure (HF) with preserved ejection fraction (HFpEF) is increasingly recognized as an important clinical entity. Preclinical studies have shown differences in the pathophysiology between HFpEF and HF with reduced ejection fraction (HFrEF). The
Externí odkaz:
https://doaj.org/article/5691576af65d4fb18a7bd3345080df69
Autor:
Brendan N Putko, Zuocheng Wang, Jennifer Lo, Todd Anderson, Harald Becher, Jason R B Dyck, Zamaneh Kassiri, Gavin Y Oudit, Alberta HEART Investigators
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99495 (2014)
Various pathways have been implicated in the pathogenesis of heart failure (HF) with preserved ejection fraction (HFPEF). Inflammation in response to comorbid conditions, such as hypertension and diabetes, may play a proportionally larger role in HFP
Externí odkaz:
https://doaj.org/article/f93dc7b6adca4905bbb389080d8a6c66
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96597 (2014)
TRPV1 channels are an important class of membrane proteins that play an integral role in the regulation of intracellular cations such as calcium in many different tissue types. The anionic phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) is
Externí odkaz:
https://doaj.org/article/22e370d9acf24785a93f5b32828a824e
Autor:
Ross A Breckenridge, Izabela Piotrowska, Keat-Eng Ng, Timothy J Ragan, James A West, Surendra Kotecha, Norma Towers, Michael Bennett, Petra C Kienesberger, Ryszard T Smolenski, Hillary K Siddall, John L Offer, Mihaela M Mocanu, Derek M Yelon, Jason R B Dyck, Jules L Griffin, Andrey Y Abramov, Alex P Gould, Timothy J Mohun
Publikováno v:
PLoS Biology, Vol 11, Iss 9, p e1001666 (2013)
Cardiomyocytes are vulnerable to hypoxia in the adult, but adapted to hypoxia in utero. Current understanding of endogenous cardiac oxygen sensing pathways is limited. Myocardial oxygen consumption is determined by regulation of energy metabolism, wh
Externí odkaz:
https://doaj.org/article/c94bc252bb4048fdb56691e64de2627d
Autor:
Dukgyu Lee, Tatsujiro Oka, Beth Hunter, Alison Robinson, Sylvia Papp, Kimitoshi Nakamura, Wattamon Srisakuldee, Barbara E Nickel, Peter E Light, Jason R B Dyck, Gary D Lopaschuk, Elissavet Kardami, Michal Opas, Marek Michalak
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56387 (2013)
Calreticulin, a Ca(2+)-buffering chaperone of the endoplasmic reticulum, is highly expressed in the embryonic heart and is essential for cardiac development. After birth, the calreticulin gene is sharply down regulated in the heart, and thus, adult h
Externí odkaz:
https://doaj.org/article/a15d0f4aedfa459a867f94f32b4da860
Autor:
T. Jake Samuel, Andrew P. Oneglia, Daisha J. Cipher, Justin A. Ezekowitz, Jason R. B. Dyck, Todd Anderson, Jonathan G. Howlett, D. Ian Paterson, Richard B. Thompson, Michael D. Nelson
Publikováno v:
Journal of Cardiovascular Magnetic Resonance, Vol 25, Iss 1, Pp 1-11 (2023)
Abstract Background Left ventricular (LV) circumferential and longitudinal strain provide important insight into LV mechanics and function, each contributing to volumetric changes throughout the cardiac cycle. We sought to explore this strain-volume
Externí odkaz:
https://doaj.org/article/6eaef079fa8c44a2ba4467c32287ada7
Autor:
Sherif M. Shoieb, Ahmad H. Alammari, Jody Levasseur, Heidi Silver, Jason R. B. Dyck, Ayman O. S. El-Kadi
Publikováno v:
Journal of Cardiovascular Pharmacology. 79:833-845
Cytochrome P450 1B1 (CYP1B1) is known to be involved in the pathogenesis of several cardiovascular diseases, including cardiac hypertrophy and heart failure, through the formation of cardiotoxic metabolites named as mid-chain hydroxyeicosatetraenoic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5353bca174ed08d58dd0ee982a643b41
https://doi.org/10.1097/fjc.0000000000001258
https://doi.org/10.1097/fjc.0000000000001258
Autor:
Mohamed Salla, Jimmy Guo, Harshad Joshi, Marilyn Gordon, Hitesh Dooky, Justine Lai, Samantha Capicio, Heather Armstrong, Rosica Valcheva, Jason R. B. Dyck, Aducio Thiesen, Eytan Wine, Levinus A. Dieleman, Shairaz Baksh
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5967
Persistent inflammation can trigger altered epigenetic, inflammatory, and bioenergetic states. Inflammatory bowel disease (IBD) is an idiopathic disease characterized by chronic inflammation of the gastrointestinal tract, with evidence of subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03633c75dfd95e88ae9f68b80af080c