Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jason R, Stephenson"'
Publikováno v:
J Neurochem
Brain endocannabinoids serve as retrograde neurotransmitters, being synthesized in post-synaptic neurons "on demand" and released to bind pre-synaptic cannabinoid receptors and suppress glutamatergic or GABAergic transmission. The most abundant brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab943454c7a2ae427c1690f55aa444e
https://doi.org/10.1111/jnc.14972
https://doi.org/10.1111/jnc.14972
Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction
Autor:
Terunaga Nakagawa, Tyler L. Perfitt, Jason R. Stephenson, Xiaohan Wang, David A. Jacobson, Matthew T. Dickerson, Roger J. Colbran
Publikováno v:
J Neurosci
The activation of neuronal plasma membrane Ca2+channels stimulates many intracellular responses. Scaffolding proteins can preferentially couple specific Ca2+channels to distinct downstream outputs, such as increased gene expression, but the molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c039ffaebabbf87c652f2db4f714b696
https://doi.org/10.1523/jneurosci.0893-19.2020
https://doi.org/10.1523/jneurosci.0893-19.2020
Autor:
Jason R. Stephenson, Xiaohan Wang, Roger J. Colbran, Christian R. Marks, Brian C. Shonesy, Colleen M. Niswender
Publikováno v:
Molecular Pharmacology. 94:1352-1362
Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and metabotropic glutamate receptor 5 (mGlu(5)) are critical signaling molecules in synaptic plasticity and learning/memory. Here, we demonstrate that mGlu(5) is present in CaMKIIα complexes iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f5cdb087a6ab1a9f013bfa68a9c160
https://doi.org/10.1124/mol.118.113142
https://doi.org/10.1124/mol.118.113142
Autor:
Oakleigh M. Folkes, Danny G. Winder, Ken Mackie, Shana M. Augustin, Walker P. Parrish, Samuel W. Centanni, Jason R. Stephenson, Roger J. Colbran, David M. Lovinger, Hala K. Haddad, Sachin Patel, Brian C. Shonesy, Keeley L. Spiess, Rebecca J. Bluett, Rita Báldi, Christian R. Marks
Publikováno v:
Biological Psychiatry. 84:304-315
Background Endocannabinoid signaling plays an important role in regulating synaptic transmission in the striatum, a brain region implicated as a central node of dysfunction in autism spectrum disorder. Deficits in signaling mediated by the endocannab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4bdda1437b5ca7db890d38e5a9f033
https://doi.org/10.1016/j.biopsych.2017.11.036
https://doi.org/10.1016/j.biopsych.2017.11.036
Autor:
James S. Sutcliffe, Tyler L. Perfitt, Roger J. Colbran, Xiaohan Wang, Walker P. Parrish, Brian C. Shonesy, Douglas P. Mortlock, Christian R. Marks, Jason R. Stephenson, Terunaga Nakagawa
Publikováno v:
The Journal of Neuroscience. 37:2216-2233
Characterizing the functional impact of novel mutations linked to autism spectrum disorder (ASD) provides a deeper mechanistic understanding of the underlying pathophysiological mechanisms. Here we show that ade novoGlu183 to Val (E183V) mutation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a5b0e40edf654a878bdfb445ac4dc8b
https://doi.org/10.1523/jneurosci.2068-16.2017
https://doi.org/10.1523/jneurosci.2068-16.2017
Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction
The molecular mechanisms that couple plasma membrane receptors/channels to specific intracellular responses, such as increased gene expression, are incompletely understood. The postsynaptic scaffolding protein Shank3 associates with Ca2+ permeable re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baafdc20311ef8f156c8220a817d7d43
Autor:
Roger J. Colbran, Jason R. Stephenson
There is abundant evidence showing that Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) plays critical roles in synaptic plasticity underlying learning and memory. This chapter reviews the fundamental biochemical properties of CaMKII that make
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dbcdd83d0ae564364734ef8fe85a754
https://doi.org/10.1016/b978-0-12-809324-5.21106-1
https://doi.org/10.1016/b978-0-12-809324-5.21106-1
Autor:
Jason R, Stephenson, Xiaohan, Wang, Tyler L, Perfitt, Walker P, Parrish, Brian C, Shonesy, Christian R, Marks, Douglas P, Mortlock, Terunaga, Nakagawa, James S, Sutcliffe, Roger J, Colbran
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(8)
Characterizing the functional impact of novel mutations linked to autism spectrum disorder (ASD) provides a deeper mechanistic understanding of the underlying pathophysiological mechanisms. Here we show that a de novo Glu183 to Val (E183V) mutation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::24c93821042b8a59100b2b9748fa276c
https://pubmed.ncbi.nlm.nih.gov/28130356
https://pubmed.ncbi.nlm.nih.gov/28130356
The N Terminus of the Adhesion G Protein-coupled Receptor GPR56 Controls Receptor Signaling Activity
Publikováno v:
Journal of Biological Chemistry. 286:28914-28921
GPR56 is an adhesion G protein-coupled receptor that plays a key role in cortical development. Mutations to GPR56 in humans cause malformations of the cerebral cortex, but little is known about the normal function of the receptor. We found that the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6ee5674ea8ba1d54d6354c79e771f3
https://doi.org/10.1074/jbc.m111.247973
https://doi.org/10.1074/jbc.m111.247973
Autor:
Marjorie A. Jones, Ahmed W. Jafri, Jon A. Friesen, Justin B. Morgenthaler, Jason R. Stephenson
Publikováno v:
American Journal of Biochemistry and Biotechnology. 4:442-449
The effects of covalent cross-linkers on the enzyme, coproporphyrinogen oxidase, had been previously studied but their role in protecting the enzyme from protease cleavage has not been evaluated. Therefore, we examined how the cross-linker bis (sulfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b97a50888856f617c7ef9557916b4f26
https://doi.org/10.3844/ajbbsp.2008.442.449
https://doi.org/10.3844/ajbbsp.2008.442.449