Glyoxylate protects against cyanide toxicity through metabolic modulation

Autor: Jason R. Nielson, Anjali K. Nath, Kim P. Doane, Xu Shi, Jangwoen Lee, Emily G. Tippetts, Kusumika Saha, Jordan Morningstar, Kevin G. Hicks, Adriano Chan, Yanbin Zhao, Amy Kelly, Tara B. Hendry-Hofer, Alyssa Witeof, Patrick Y. Sips, Sari Mahon, Vikhyat S. Bebarta, Vincent Jo Davisson, Gerry R. Boss, Jared Rutter, Calum A. MacRae, Matthew Brenner, Robert E. Gerszten, Randall T. Peterson

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)

Abstract Although cyanide’s biological effects are pleiotropic, its most obvious effects are as a metabolic poison. Cyanide potently inhibits cytochrome c oxidase and potentially other metabolic enzymes, thereby unleashing a cascade of metabolic pe

Externí odkaz: https://doaj.org/article/cb54f482aaef485c9442a4f1d31f3076

Emerimicins V-X, 15-Residue Peptaibols Discovered from an

Autor: Guangwei, Wu, Bryn T M, Dentinger, Jason R, Nielson, Randall T, Peterson, Jaclyn M, Winter

Publikováno v: Journal of natural products. 84(4)

Fermentation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0ef05a8e5566b7d4f7c67fdbde3c728
https://pubmed.ncbi.nlm.nih.gov/33617244

Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning

Autor: Gerry R. Boss, V. Jo Davisson, Amy E. Kelly, Robert E. Gerszten, Patrick Sips, Vikhyat S. Bebarta, Brittney Mikell, Matthew Brenner, Jared Rutter, Gabriel Musso, Eva Buys, Jason R. Nielson, Xu Shi, Calum A. MacRae, Anjali K. Nath, Yanbin Zhao, Jordan Morningstar, Sari B. Mahon, Randall T. Peterson

Publikováno v: PLOS ONE
PLoS ONE
Sips, PY; Shi, X; Musso, G; Nath, AK; Zhao, Y; Nielson, J; et al.(2018). Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS ONE, 13(6). doi: 10.1371/journal.pone.0193889. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4h36k9gd
PLoS ONE, Vol 13, Iss 6, p e0193889 (2018)
Sips, PY; Shi, X; Musso, G; Nath, AK; Zhao, Y; Nielson, J; et al.(2018). Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLOS ONE, 13(6). doi: 10.1371/journal.pone.0193839. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/04173853

© 2018 Sips et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cred

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2c4680cfa5086e5ce4808fafe68ab8
https://biblio.ugent.be/publication/8566091

Bonnevillamides, Linear Heptapeptides Isolated from a Great Salt Lake-Derived Streptomyces sp

Autor: Jaclyn M. Winter, Randall T. Peterson, Jason R. Nielson, Guangwei Wu

Publikováno v: Marine Drugs; Volume 15; Issue 7; Pages: 195
Marine Drugs

Streptomyces sp. GSL-6B was isolated from sediment collected from the Great Salt Lake and investigation of its organic extract led to the isolation of three new linear heptapeptides, bonnevillamides A (1), B (2), and C (3). The bonnevillamides repres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d99a37be78ed685c175c815c821d7f