Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jason R, Chan"'
Autor:
Joo-Yun Byun, Yi T. Koh, Sun Young Jang, Jennifer W. Witcher, Jason R. Chan, Anna Pustilnik, Mark J. Daniels, Young Hoon Kim, Kwee Hyun Suh, Matthew D. Linnik, Young-Mi Lee
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The selective Bruton tyrosine kinase (BTK) inhibitor poseltinib has been shown to inhibit the BCR signal transduction pathway and cytokine production in B cells (Park et al. Arthritis Res. Ther. 18, 91, https://doi.org/10.1186/s13075-016-098
Externí odkaz:
https://doaj.org/article/f84752f1ec4c42a4a963b56dd9003005
Autor:
Erica L. Bradshaw, Mary E. Spilker, Richard Zang, Loveleena Bansal, Handan He, Rhys D.O. Jones, Kha Le, Mark Penney, Edgar Schuck, Brian Topp, Alice Tsai, Christine Xu, Marjoleen J.M.A. Nijsen, Jason R. Chan
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 11, Pp 777-791 (2019)
Abstract Quantitative systems pharmacology (QSP) approaches have been increasingly applied in the pharmaceutical since the landmark white paper published in 2011 by a National Institutes of Health working group brought attention to the discipline. In
Externí odkaz:
https://doaj.org/article/cfab4d71279e43a58805b6626dcdac0c
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 340-343 (2019)
Externí odkaz:
https://doaj.org/article/95157eae33704c0da3564f6c60dfa101
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 344-346 (2019)
Externí odkaz:
https://doaj.org/article/6f2429f9fdfe47dfbaeddd5455824db8
Autor:
Jason R. Chan, Richard Allen, Britton Boras, Antonio Cabal, Valeriu Damian, Francis D. Gibbons, Abhishek Gulati, Iraj Hosseini, Jeffrey D. Kearns, Ryuta Saito, Lourdes Cucurull-Sanchez, Jangir Selimkhanov, Andrew M. Stein, Kenichi Umehara, Guanyu Wang, Weirong Wang, Susana Neves-Zaph
Publikováno v:
Journal of pharmacokinetics and pharmacodynamics.
Quantitative Systems Pharmacology (QSP) modeling is increasingly applied in the pharmaceutical industry to influence decision making across a wide range of stages from early discovery to clinical development to post-marketing activities. Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980e84f1c99e14567b1bde531244a584
https://pubmed.ncbi.nlm.nih.gov/35953664
https://pubmed.ncbi.nlm.nih.gov/35953664
Autor:
Jason R Chan, Gregory Vuillaume, Caitlin Bever, Stefan Lebrun, Michael Lietz, Yvonne Steffen, Katrin Stolle, Karim Wahba, Xiao Wang, Shonna Moodie, Julia Hoeng, Manuel C Peitsch, Lyn M Powell
Publikováno v:
BioDiscovery, Vol 3, Iss , Pp 1-13 (2012)
Motivation:Atherosclerosis is a complex multi-pathway inflammatory disease where accumulation of oxidatively modified lipids and leukocytes in the arterial intima leads to plaque formation over time. Translating Apoe-/- mouse results to the clinical
Externí odkaz:
https://doaj.org/article/e87ffa701b074622a23a688c4c0f1401
Autor:
Marjoleen Nijsen, Brian Topp, Edgar Schuck, Richard Zang, Handan He, Loveleena Bansal, Rhys D.O. Jones, Erica L. Bradshaw, Alice Tsai, Mark Penney, Kha Le, Jason R. Chan, Mary E. Spilker, Christine Xu
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 11, Pp 777-791 (2019)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
Quantitative systems pharmacology (QSP) approaches have been increasingly applied in the pharmaceutical since the landmark white paper published in 2011 by a National Institutes of Health working group brought attention to the discipline. In this per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef90e38f540b99780bbc2c9356c3236
https://doi.org/10.1002/psp4.12463
https://doi.org/10.1002/psp4.12463
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 340-343 (2019)
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49640f662f9b353b83c436bbe30faf11
https://doi.org/10.1002/psp4.12409
https://doi.org/10.1002/psp4.12409
Autor:
Alexandre Boutet, Andres M. Lozano, Mojgan Hodaie, Ailish Coblentz, Kullervo Hynynen, Eugen Hlasny, Gabriel A. Devenyi, Walter Kucharczyk, Christopher S Lozano, Gavin J B Elias, Maheleth Llinas, Alfonso Fasano, Jidan Zhong, Jason R. Chan, David S. Xu, M. Mallar Chakravarty, Nir Lipsman, Jürgen Germann, Michael L. Schwartz, Manish Ranjan
Publikováno v:
Brain. 141:3405-3414
Magnetic resonance guided focused ultrasound (MRgFUS) thalamotomy is a novel and minimally invasive ablative treatment for essential tremor. The size and location of therapeutic lesions producing the optimal clinical benefits while minimizing adverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b17db47dd4642a7e3d43a12eb275d7c
https://doi.org/10.1093/brain/awy278
https://doi.org/10.1093/brain/awy278
Autor:
Erica L. Bradshaw-Pierce, Anjaneya Chimalakonda, Bianca M. Liederer, Loveleena Bansal, Edgar Schuck, Alice Tsai, Fan Wu, Marjoleen Nijsen, Mary E. Spilker, Jason R. Chan, Patricia Schroeder, Jerome T. Mettetal, Kha Le, Akihiro Yamada, Brian Topp, Mark Penney, Christine Xu
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 7:135-146
A cross-industry survey was conducted to assess the landscape of preclinical quantitative systems pharmacology (QSP) modeling within pharmaceutical companies. This article presents the survey results, which provide insights on the current state of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66d9d94cf63a1d82165b3f3fbd353d6c
https://doi.org/10.1002/psp4.12282
https://doi.org/10.1002/psp4.12282