Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jason Piotrowski"'
Autor:
Peter Revill, Yuji Teraoka, Mitsutaka Osawa, Zhensheng Zhang, Jason Piotrowski, T. Jake Liang, Vitina Sozzi, Yuji Ishida, Takeshi Saito, Kazuaki Chayama, Min Zhang, Michio Imamura
Publikováno v:
J Hepatol
Background & Aims HBV consists of 9 major genotypes (A to I), 1 minor strain (designated J) and multiple subtypes, which may be associated with different clinical characteristics. As only cell lines expressing genotype D3 have been established, herei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3dc7947b18c7d67f831755262a303c
https://europepmc.org/articles/PMC8604785/
https://europepmc.org/articles/PMC8604785/
Autor:
Brian A. Lewis, Jason Piotrowski, Kairong Cui, Craig J. Thomas, Damian Wojtowicz, Laura Baranello, Xiaohu Zhang, B. Franklin Pugh, Ballachanda N. Devaiah, Dinah S. Singer, Rajarshi Guha, Kelli M. Wilson, Teresa M. Przytycka, Hye Jung Chung, Keji Zhao, David Levens, Fedor Kouzine, Yves Pommier, Hongliang Zhang, Ka Yim Chan-Salis
Publikováno v:
Cell. 165:357-371
We report a mechanism through which the transcription machinery directly controls topoisomerase 1 (TOP1) activity to adjust DNA topology throughout the transcription cycle. By comparing TOP1 occupancy using chromatin immunoprecipitation sequencing (C
Publikováno v:
Journal of Biological Chemistry. 282:36403-36411
Metal-catalyzed oxidation reactions target amino acids in the metal binding pocket of proteins. Such oxidation reactions generally result in either preferential degradation of the protein or accumulation of a catalytically inactive pool of protein wi
Autor:
Jeanine A. Harrigan, William Ramos, Istvan Boldogh, Marc M. Greenberg, Nadja de Souza Pinto, Tapas K. Hazra, Jae Wan Lee, Vilhelm A. Bohr, Muralidhar L. Hegde, Sankar Mitra, Jason Piotrowski, Aditi Das
Publikováno v:
Journal of Biological Chemistry. 282:26591-26602
The mammalian DNA glycosylase, NEIL1, specific for repair of oxidatively damaged bases in the genome via the base excision repair pathway, is activated by reactive oxygen species and prevents toxicity due to radiation. We show here that the Werner sy
Autor:
Renjie Jiao, Tobias Dietschy, Jason Piotrowski, Igor Shevelev, J A Harrigan, Fred E. Indig, Vilhelm A. Bohr, Igor Stagljar, Pavel Janscak, N Selak
Publikováno v:
Oncogene. 26:3811-3822
The Werner syndrome protein (WRN) and chromatin assembly factor 1 (CAF-1) are both involved in the maintenance of genome stability. In response to DNA-damaging signals, both of these proteins relocate to sites where DNA synthesis occurs. However, the
Autor:
Susan P. Lees Miller, Parimal Karmakar, Robert M. Brosh, Wen-Hsing Cheng, Dale A. Ramsden, Jason Piotrowski, Vilhelm A. Bohr, Joshua A. Sommers, Carey M. Snowden
Publikováno v:
Journal of Biological Chemistry. 277:18291-18302
Human Werner Syndrome is characterized by early onset of aging, elevated chromosomal instability, and a high incidence of cancer. Werner protein (WRN) is a member of the recQ gene family, but unlike other members of the recQ family, it contains a uni
Autor:
Parimal Karmakar, Patricia L. Opresko, Robert M. Brosh, Irina I. Dianova, Grigory L. Dianov, Cayetano von Kobbe, Vilhelm A. Bohr, Jason Piotrowski, Joshua A. Sommers
Publikováno v:
The EMBO Journal. 20:5791-5801
Werner syndrome (WS) is a human premature aging disorder characterized by chromosomal instability. The cellular defects of WS presumably reflect compromised or aberrant function of a DNA metabolic pathway that under normal circumstances confers stabi
Publikováno v:
Journal of Biological Chemistry. 273:33811-33816
The repair pathways involved in the removal of 8-oxo-7, 8-dihydroguanine (8-oxoguanine) in DNA by mammalian cell extracts have been examined. Closed circular DNA constructs containing a single 8-oxoguanine at a defined site were used as substrates to
Autor:
J. P. Scovill, Michael Adler, Jason Piotrowski, Gerald W. Parker, Sharad S. Deshpande, Frank J. Lebeda
Publikováno v:
Toxicon. 33:527-537
The effects of the potassium channel inhibitor and putative botulinum toxin antagonist 3,4-diaminopyridine (3,4-DAP) were investigated in vitro on the contractile properties of rat diaphragm muscle. In the presence of 100 pM botulinum neurotoxin A (B
Autor:
Gad Beck, Jae Wan Lee, Vilhelm A. Bohr, Meltem Muftuoglu, Tomasz Kulikowicz, Jason Piotrowski
Publikováno v:
Biochemistry. 47(39)
Werner syndrome (WS) is a rare autosomal recessive disorder in humans characterized by premature aging and genetic instability. WS is caused by mutations in the WRN gene, which encodes a member of the RecQ family of DNA helicases. Cellular and bioche