Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jason Pierson"'
Autor:
Elena Gustchina, Mi Li, Rodolfo Ghirlando, Peter Schuck, John M Louis, Jason Pierson, Prashant Rao, Sriram Subramaniam, Alla Gustchina, G Marius Clore, Alexander Wlodawer
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78187 (2013)
A series of mini-antibodies (monovalent and bivalent Fabs) targeting the conserved internal trimeric coiled-coil of the N-heptad repeat (N-HR) of HIV-1 gp41 has been previously constructed and reported. Crystal structures of two closely related monov
Externí odkaz:
https://doaj.org/article/1a35b1013b964c889319795eda95b490
Autor:
Musa Sani, Edith N G Houben, Jeroen Geurtsen, Jason Pierson, Karin de Punder, Maaike van Zon, Brigitte Wever, Sander R Piersma, Connie R Jiménez, Mamadou Daffé, Ben J Appelmelk, Wilbert Bitter, Nicole van der Wel, Peter J Peters
Publikováno v:
PLoS Pathogens, Vol 6, Iss 3, p e1000794 (2010)
The cell envelope of mycobacteria, a group of Gram positive bacteria, is composed of a plasma membrane and a Gram-negative-like outer membrane containing mycolic acids. In addition, the surface of the mycobacteria is coated with an ill-characterized
Externí odkaz:
https://doaj.org/article/a12f7988b59b4c7baf3a0c7c5df3d5ce
Publikováno v:
Neurobiology of aging, vol 34, iss 6
During prion disease, cellular prion protein (PrP(C)) is refolded into a pathogenic isoform (PrP(Sc)) that accumulates in the central nervous system and causes neurodegeneration and death. We used immunofluorescence, quantitative cryo-immunogold EM,
Autor:
Sriram Subramaniam, Alan Merk, Prashant Rao, Lesley A. Earl, Mario J. Borgnia, Veronica Falconieri, Jacqueline L. S. Milne, Alberto Bartesaghi, Doreen Matthies, Soojay Banerjee, Jason Pierson
Publikováno v:
Molecular Pharmacology
Cryo-electron microscopy (cryo-EM) methods are now being used to determine structures at near-atomic resolution and have great promise in molecular pharmacology, especially in the context of mapping the binding of small-molecule ligands to protein co
Autor:
Peter J. Peters, Jason Pierson
Publikováno v:
Microscopy and Microanalysis. 23:2310-2311
Publikováno v:
Microscopy. 60:S93-S100
A major objective of modern structural biology is to appreciate the cellular organization by elucidating the spatial arrangement of macromolecular complexes within a cell. Cryogenic sample preparation, combined with cryo-ultramicrotomy, enables large
Publikováno v:
Journal of Structural Biology. 173:345-349
Vitreous cryo-section-induced compression influences the interpretation and the reliability of electron microscopy images and tomographic reconstructions. Previous studies of this deformation have been focused at the cellular level where considerable
Publikováno v:
Histochemistry and Cell Biology
The cellular nanocosm is made up of numerous types of macromolecular complexes or biological nanomachines. These form functional modules that are organized into complex subcellular networks. Information on the ultra-structure of these nanomachines ha
Publikováno v:
Traffic. 9:1653-1664
The endoplasmic reticulum (ER) in Saccharomyces cerevisiae is largely divided between perinuclear and cortical compartments. Yeast Nvj1 localizes exclusively to small patches on the perinuclear ER where it interacts with Vac8 in the vacuole membrane
Publikováno v:
Journal of Microscopy. 224:129-134
Sectioning vitrified cells and tissues for cryo-electron microscopy is more challenging than room-temperature sectioning of plastic-embedded samples. As the sample must be kept very cold (