Výsledky vyhledávání - "Jason P. Stanko"

Microphysiological Systems Evaluation: Experience of TEX-VAL Tissue Chip Testing Consortium

Autor: Ivan Rusyn, Courtney Sakolish, Yuki Kato, Clifford Stephan, Leoncio Vergara, Philip Hewitt, Vasanthi Bhaskaran, Myrtle Davis, Rhiannon N Hardwick, Stephen S Ferguson, Jason P Stanko, Piyush Bajaj, Karissa Adkins, Nisha S Sipes, E Sidney Hunter, Maria T Baltazar, Paul L Carmichael, Kritika Sadh, Richard A Becker

Publikováno v: Toxicol Sci

Much has been written and said about the promise and excitement of microphysiological systems, miniature devices that aim to recreate aspects of human physiology on a chip. The rapid explosion of the offerings and persistent publicity placed high exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fe00b5247331ff1b276233e30fd420
https://pubmed.ncbi.nlm.nih.gov/35689632

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Disposition and metabolism of antibacterial agent, triclocarban, in rodents; a species and route comparison

Autor: Suramya Waidyanatha, Scott L. Watson, Timothy R. Fennell, Sherry R Black, Rodney W. Snyder, Jason P. Stanko, Vicki Sutherland, Purvi R. Patel

Publikováno v: Xenobiotica

Triclocarban is a residue-producing antibacterial agent used in a variety of consumer products. These studies investigated the disposition and metabolism of [14C]triclocarban.In male rats following a single gavage administration of 50, 150, and 500 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aff4028e59b7a18cb8fc675be8d4591c

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Application of Sholl analysis to quantify changes in growth and development in rat mammary gland whole mounts

Autor: Michael R. Easterling, Suzanne E. Fenton, Jason P. Stanko

Publikováno v: Reproductive Toxicology. 54:129-135

Studies that utilize the rodent mammary gland (MG) as an endpoint for assessing the developmental toxicity of chemical exposures typically employ either basic dimensional measurements or developmental scoring of morphological characteristics as a mea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ee137e2ede91c9c7bb041d92f4f7ab
https://doi.org/10.1016/j.reprotox.2014.11.004

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Quantifying Branching Density in Rat Mammary Gland Whole-mounts Using the Sholl Analysis Method

Autor: Suzanne E. Fenton, Jason P. Stanko

Publikováno v: Journal of Visualized Experiments.

An increasing number of studies are utilizing the rodent mammary gland as an endpoint for assessing the developmental toxicity of a chemical exposure. The effects these exposures have on mammary gland development are typically evaluated using either

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e573c169dc78e74d5d58d927ada503
https://doi.org/10.3791/55789-v

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Differences in the Rate of in Situ Mammary Gland Development and Other Developmental Endpoints in Three Strains of Female Rat Commonly Used in Mammary Carcinogenesis Studies: Implications for Timing of Carcinogen Exposure

Autor: Suzanne E. Fenton, Vesna A. Chappell, Grace E. Kissling, Jason P. Stanko

Publikováno v: Toxicologic pathology. 44(7)

The potential of chemicals to alter susceptibility to mammary tumor formation is often assessed using a carcinogen-induced study design in various rat strains. The rate of mammary gland (MG) development must be considered so that the timing of carcin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1ac75e49ad5ab3113f2971dc68912d
https://pubmed.ncbi.nlm.nih.gov/27613105

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Analysis of PFOA in dosed CD1 mice: Part 1. Methods development for the analysis of tissues and fluids from pregnant and lactating mice and their pups

Autor: Jason P. Stanko, Shoji F. Nakayama, Jessica L. Reiner, Andrew B. Lindstrom, Amy D. Delinsky, Suzanne E. Fenton, Mark J. Strynar

Publikováno v: Reproductive Toxicology. 27:360-364

The number of studies involving the analysis of perfluorooctanoic acid (PFOA) has increased recently because PFOA is routinely detected in human blood samples from around the world. Recent studies with mice have shown that dosing pregnant dams with P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c4c298f40a8854f194f7a2c140c695
https://doi.org/10.1016/j.reprotox.2008.10.006

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Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life☆

Autor: Sally S. White, Erin P. Hines, Suzanne E. Fenton, Jason P. Stanko, Christopher Lau, Eugene A. Gibbs-Flournoy

Publikováno v: Molecular and Cellular Endocrinology. 304:97-105

The synthetic surfactant, perfluorooctanoic acid (PFOA) is a proven developmental toxicant in mice, causing pregnancy loss, increased neonatal mortality, delayed eye opening, and abnormal mammary gland growth in animals exposed during fetal life. PFO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d725846fa57613e6788130ad4343cb50
https://doi.org/10.1016/j.mce.2009.02.021

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Prenatal perfluorooctanoic acid exposure in CD-1 mice: low-dose developmental effects and internal dosimetry

Autor: Katoria Tatum-Gibbs, Mark J. Strynar, LaTonya R. Villanueva, Sally S. White, Madisa B. Macon, Jason P. Stanko, Suzanne E. Fenton, Laurence Helfant, Robert D. Zehr

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 122(1)

Perfluorooctanoic acid (PFOA) is an environmental contaminant that causes adverse developmental effects in laboratory animals. To investigate the low-dose effects of PFOA on offspring, timed-pregnant CD-1 mice were gavage dosed with PFOA for all or h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b469c27ffa7e9bca73904ea065b75b7d
https://pubmed.ncbi.nlm.nih.gov/21482639

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Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay

Autor: Retha R. Newbold, Elizabeth A. Wallace, Casey E. Reed, Suzanne E. Fenton, Erin P. Hines, Wendy N. Jefferson, Darlene Dixon, Alicia B. Moore, Yi Lu, Jason P. Stanko, Eugene A. Gibbs-Flournoy

Publikováno v: Reproductive toxicology (Elmsford, N.Y.). 33(4)

The estrogenic and antiestrogenic potential of perfluorooctanoic acid (PFOA) was assessed using an immature mouse uterotrophic assay and by histologic evaluation of the uterus, cervix and vagina following treatment. Female offspring of CD-1 dams were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db31ba364613d9cbcce4b5802f8e64fb
https://pubmed.ncbi.nlm.nih.gov/22146484

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Gestational and chronic low-dose PFOA exposures and mammary gland growth and differentiation in three generations of CD-1 mice

Autor: Antonia M. Calafat, Suzanne E. Fenton, Kayoko Kato, Sally S. White, Jason P. Stanko, Erin P. Hines

Publikováno v: Environmental Health Perspectives

Background: Prenatal exposure to perfluorooctanoic acid (PFOA), a ubiquitous industrial surfactant, has been reported to delay mammary gland development in female mouse offspring (F1) and the treated lactating dam (P0) after gestational treatments at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540a2263b0590cfd4d84ed09fdc6c105
https://pubmed.ncbi.nlm.nih.gov/21501981

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