Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jason P. Schrum"'
Autor:
Elizabeth Gray, Kelly Hensley, Sean Allred, Robert Thurman, Katie Snead, Michelle Ulrich, Dannah Miller, Serena Wo, Angela Epp, Disha Sahetya, Julie Hahn, Chris Frantz, Natalya Nazarenko, Kellie Spahr, Patrick Younan, Li-Ya Huang, Kristen Gahnberg, Piper M Treuting, Esther S Trueblood, John J Gosink, Evgenia Jane Haass, Mary Padilla, Alyson J Smith, Jason P Schrum, Shyra J Gardai
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Background SGN-B7H4V is a novel investigational vedotin antibody–drug conjugate (ADC) comprising a B7-H4-directed human monoclonal antibody conjugated to the cytotoxic payload monomethyl auristatin E (MMAE) via a protease-cleavable maleimidocaproyl
Externí odkaz:
https://doaj.org/article/f885976e5e104e04a8016c6dbb713fb4
Autor:
Sheila Ranganath, John P. Manis, Jayanta Chaudhuri, Craig Alpert, Uttiya Basu, Jason P. Schrum, Frederick W. Alt, Gang Li, Shilpee Dutt
Publikováno v:
Nature. 438:508-511
Antibodies, which are produced by B-lineage cells, consist of immunoglobulin heavy (IgH) and light (IgL) chains that have amino-terminal variable regions and carboxy-terminal constant regions. In response to antigens, B cells undergo two types of gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b5e11e9990b67312e077c15ac6a05e
https://doi.org/10.1038/nature04255
https://doi.org/10.1038/nature04255
Publikováno v:
Journal of Biological Chemistry. 279:43448-43461
Recent literature implicates a regulatory function of the juxtamembrane domain (JMD) in receptor tyrosine kinases. Mutations in the JMD of c-Kit and Flt3 are associated with gastrointestinal stromal tumors and acute myeloid leukemias, respectively. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9a7432a61e476580464c9417f42b15
https://doi.org/10.1074/jbc.m314170200
https://doi.org/10.1074/jbc.m314170200
Publikováno v:
Cold Spring Harbor perspectives in biology. 2(9)
Understanding the origin of cellular life on Earth requires the discovery of plausible pathways for the transition from complex prebiotic chemistry to simple biology, defined as the emergence of chemical assemblies capable of Darwinian evolution. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2cbf0b6aa42a7ee4ac0bde83665826e
https://pubmed.ncbi.nlm.nih.gov/20484387
https://pubmed.ncbi.nlm.nih.gov/20484387
Publikováno v:
Journal of the American Chemical Society
The development of a sequence-general nucleic acid copying system is an essential step in the assembly of a synthetic protocell, an autonomously replicating spatially localized chemical system capable of spontaneous Darwinian evolution. Previously de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb131dcf88a17a8bb950f3921140f5cb
https://pubmed.ncbi.nlm.nih.gov/19757789
https://pubmed.ncbi.nlm.nih.gov/19757789
Autor:
Sheref S. Mansy, Douglas A. Treco, Jack W. Szostak, Mathangi Krishnamurthy, Sylvia Tobe, Jason P. Schrum
Publikováno v:
Nature. 454(7200)
The phospholipids that form the membranes of modern cells present a formidable barrier to polar and charged molecules, necessitating complex channels and pumps to permit the exchange of molecules with the external environment. This presents a problem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb14ecaaf77cd884599159fbd138be2
https://pubmed.ncbi.nlm.nih.gov/18596792
https://pubmed.ncbi.nlm.nih.gov/18596792