Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Jason P. Eiserich"'
Autor:
Brian M. Morrissey, Michele A. La Merrill, Carroll E. Cross, Sean Ott, Keri A. Hayakawa, Tamara Kadir, Jason P. Eiserich
Publikováno v:
Free Radical Biology and Medicine. 129:146-154
Rationale Cystic fibrosis (CF) patients are known to produce cyanide (CN-) although challenges exist in determinations of total levels, the precise bioactive levels, and specificity of its production by CF microflora, especially P. aeruginosa. Our ob
Autor:
Jason P. Eiserich, Tomas Perecko, Stephan Baldus, Silvie Kremserová, Lukáš Kubala, Anna Klinke, Karel Souček
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2016 (2016)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Systemic inflammation accompanying diseases such as sepsis affects primarily lungs and induces their failure. This remains the most common cause of sepsis induced mortality. While neutrophils play a key role in pulmonary failure, the mechanisms remai
Autor:
Jason P. Eiserich, M. Adam, Hana Kolarova, Silvie Kremserová, Stephan Baldus, Michaela Pekarova, Anna Klinke, Lukáš Kubala
Publikováno v:
Europe PubMed Central
The release of myeloperoxidase (MPO) from polymorphonuclear neutrophils is a hallmark of vascular inflammation and contributes to the pathogenesis of vascular inflammatory processes. However, the effects of MPO on platelets as a contributory mechanis
Publikováno v:
Annals of the New York Academy of Sciences. 1259:1-9
Cystic fibrosis (CF) is associated with abnormal lipid metabolism, intense respiratory tract (RT) infection, and inflammation, eventually resulting in lung tissue destruction and respiratory failure. The CF RT inflammatory milieu, as reflected by air
Autor:
David Z. Silberstein, Karen A. McDonald, Kalimuthu Karuppanan, Carroll E. Cross, Jason P. Eiserich
Publikováno v:
Free Radical Biology and Medicine. 100:S59-S60
Alpha-1 antitrypsin (AAT) is an acute phase protease inhibitor. Currently, the only available treatment for patients with COPD caused by AAT deficiency is replacement therapy, requiring weekly infusions of human plasma-derived AAT. While AAT has show
Autor:
Bruce D. Hammock, Lukáš Kubala, Jason P. Eiserich, Stephan Baldus, Kara R. Schmelzer, Anna Klinke, Hana Kolarova
Publikováno v:
Free Radical Biology and Medicine. 48:1311-1320
article i nfo Acute inflammation is a common feature of many life-threatening pathologies, including septic shock. One hallmark of acute inflammation is the peroxidation of polyunsaturated fatty acids forming bioactive products that regulate inflamma
Autor:
Anna L.P. Chapman, Brian M. Morrissey, Maya Juarez, Carroll E. Cross, Vihas T. Vasu, Chin-Shang Li, Jessica S. Houghton, Jason P. Eiserich
Publikováno v:
Journal of Cystic Fibrosis. 9:84-92
BackgroundDecreased expired nitric oxide (eNO) is commonly observed in cystic fibrosis (CF) patients and is usually explained by dysregulation of NO synthase (NOS) isoforms in respiratory tract epithelium. Later stages of this disease are accompanied
Autor:
Pierluigi Stipa, Jason P. Eiserich, Elisa Proietti, Carroll E. Cross, Madhu S. Budamagunta, Lucedio Greci, John C. Voss, Riccardo Castagna
Publikováno v:
Atmospheric Environment. 42:6551-6554
We studied the reaction between hypochlorite anion ( − OCl) and hydrogen peroxide (H 2 O 2 ) by using spin-trapping agents such as 5,5-dimethyl-1-pyrroline- N -oxide (DMPO) and 5-diethoxy-phosphoryl-5-methyl-1-pyrroline- N -oxide (DEPMPO). The obta
Autor:
Andrew F. Powers, Rama S. Kota, John C. Rutledge, Sarada D. Tetali, Adam E. Mullick, Jason P. Eiserich
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 27:339-345
Objective— Although apolipoprotein E3 (apoE3) is known to be atheroprotective, its mechanisms of protection in endothelial cells remain unclear. Methods and Results— Cultured human aortic endothelial cells were stimulated with tumor necrosis fact
Publikováno v:
Free Radical Biology and Medicine. 41:1542-1547
Oxidative stress is implicated in the pathogenesis of Alzheimer's disease (AD), and the enzyme myeloperoxidase (MPO) has been identified as one source of reactive oxidants. MPO-mediated oxidation of high-density lipoprotein (HDL) plays an important r