Roles of electrostatics and conformation in protein-crystal interactions.

Autor: Paul V Azzopardi, Jason O'Young, Gilles Lajoie, Mikko Karttunen, Harvey A Goldberg, Graeme K Hunter

Publikováno v: PLoS ONE, Vol 5, Iss 2, p e9330 (2010)

In vitro studies have shown that the phosphoprotein osteopontin (OPN) inhibits the nucleation and growth of hydroxyapatite (HA) and other biominerals. In vivo, OPN is believed to prevent the calcification of soft tissues. However, the nature of the i

Externí odkaz: https://doaj.org/article/3a0b7d3c9e814018a29a8a2f38de0989

Abstracts of Poster Presentations

Autor: Amjad Javed, Sarah L. Dallas, Mitsuhiro Enjo, Jeffrey A. Winkles, Bernd Grohe, Colette A. Inkson, David W. Rowe, Tatiana Foroud, Jim Simmer, Hitesh Kapadia, Chi P. Lee, Frédéric Lézot, Chunxi Ge, Bill Daly, Ryuichi Fujisawa, Jason O’Young, Izabela Maciejewska, Ana Carolina Acevedo, Hua Wu, Yanming Bi, L. Lausten, L.F. Bonewald, Matthew R. Allen, Patricia A. Veno, Hongshan Zhao, Laurie K. McCauley, Dominique Hotton, Mina Mina, Soraya E. Gutierrez, Wu Li, Faiza Afzal, Johanne LeBihan, Dana Olton, Hailan Feng, Elizabeth Lowder, L.M. Paula, Nabil G. Seidah, Gabriele Mues, Larry W. Fisher, Masato Tamura, Tao Peng, Z. Schwartz, J. Katz, Marjorie Weaver, Jolene Bohensky, Dong Yan, William T. Butler, Ling Ye, Sara Jeffrey, Ejvis Lamani, Jinhua Li, Daming Fan, Kurtulus Golcuk, Eric T. Everett, Carolyn W. Gibson, Muhanad Aïoub, M. Johnson, Peter S. N. Rowe, Ming Zhong, Lynda F. Bonewald, J.R. Néfussi, Gérard Goubin, Noritaka Isogai, A.C. Acevedo, Yong Li, Harvey A. Goldberg, Janet Moradian-Oldak, Yan Li, Vickram Srinivas, M.T. Hincke, C. Barragan-Adjemian, Thuan Le, Bat Ami Gotliv, Yuka Shinmura, Xiaoxia Zhang, Martin Montecino, Yixia Xie, Xiaowei Su, Paul H. Krebsbach, Sharon Segvich, Michèle Garabédian, Joseph M. Wallace, Frederick H. Silver, Li Zhu, Chaoying Cui, Mohammad Q. Hassan, Laurence Pibouin, Sharanjot Saini, Jian Q. Feng, Mila Spevak, Ivo Kalajzic, Sergei A. Kuznetsov, M.D. McKee, Chunlin Qin, Renny T. Franceschi, Esben S. Sørensen, Sylvie Babajko, Laurent Ameye, Barbara Rodgers, Di Jiang, Mireille Bonnefoix, Yixin Wu, Michel Goldberg, Janet L. Stein, Bingzhen Huang, Coralee E. Tye, Robin Jacquet, Mikko Karttunen, Michael D. Morris, Rachel L. Lorenz, Karl J. Jepsen, Pamela DenBesten, J. Timothy Wright, Zhi-An Yuan, Yoshinori Shinohara, Chad M. Novince, Jane B. Lian, Rajamani Lakshminarayanan, Wilbur Tong, Jingfeng Wu, W. Kim Seow, Hyon Jong Kim, John D. Bartlett, Lixiang Liu, Céline Gaucher, Sharon B. Midura, Zvi Schwartz, Sara Chirico, Alastair James Sloan, Nehal Al Tarhuni, Shuo Chen, Hernan Roca, Petros Papagerakis, Adele L. Boskey, Ellen P. Henderson, Darrell H. Carney, Donghyun Lee, Irving M. Shapiro, Tchilalo Boukpessi, David H. Kohn, Graeme K. Hunter, Dominique Septier, Yoshitaka Wada, Amit Vasanji, Juan Dong, Urban Lindgren, Hayden William Courtland, Jan C.-C. Hu, Guozhi Xiao, Mark Stephen Litaker, Brent B. Ward, Nan E. Hatch, James P. Simmer, Marian F. Young, Stéphane Petit, Chang Du, B.D. Boyan, Fleur Meary, Ashok B. Kulkarni, M. MacDougall, Arthur Veis, Gabrielle Mues, Kaleem Zaidi, Mitsuaki Ono, Zhi Sun, E. Angeles Martinez-Mier, Subhashis Biswas, Isabelle Fernandes, Thomas C. Hart, Jong-Sup Bae, Cynthia Suggs, Mildred C. Embree, Shelley E. Brown, Jonathan A. R. Gordon, Jerry Q. Feng, Nadder D. Sahar, Prashant N. Kumta, William J. Landis, Jitesh Pratap, Melissa Aragon, Rachel J. Waddington, J. Dong, Udo Becker, Kotaro Tanimoto, Andre J. van Wijnen, Rena N. D'Souza, Ronald J. Midura, Yongbo Lu, Jan Hu, Anamaria Balic, Jeffrey P. Gorski, Charles Sfeir, Ying Wang, Yao Sun, Frédéric Jehan, Darrin Simmons, Mary MacDougall, Bill Daley, Disheng Qin, Yuanyuan Hu, Masaki J. Honda, Hanson Fong, L.J.S. Santos, P. Suzanne Hart, Gary S. Stein, Tina M. Kilts, Catherine Chaussain-Miller, Y.-C. Chien, Lars-Arne Haldosén, D.B. Ang, Barbara D. Boyan, Muriel Molla, Sarah Jane Youde, Thorsten Kirsch, Ariane Berdal, Jennifer Rosser, Morimichi Mizuno, Yuwei Fan, Kathy K.H. Svoboda, Nichole T. Huffman, James T. Ryaby, Carl-Magnus Bäckesjö, Cielo Barragan-Adjemian

Publikováno v: Cells Tissues Organs. 189:295-302

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffa03427b11134d90aeead2caf464fd
https://doi.org/10.1159/000163688

Control of Calcium Oxalate Crystal Growth by Face-Specific Adsorption of an Osteopontin Phosphopeptide

Autor: DA Ionescu, Gilles A. Lajoie, Harvey A. Goldberg, Mej Mikko Karttunen, Bernd Grohe, Graeme K. Hunter, Jason O’Young, Kem A. Rogers

Publikováno v: Journal of the American Chemical Society, 129(48), 14946-14951. American Chemical Society

Mineral-associated proteins have been proposed to regulate many aspects of biomineralization, including the location, type, orientation, shape, and texture of crystals. To understand how proteins achieve this exquisite level of control, we are studyi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fbbbc18af406c9940c49ccd87dc6863
https://doi.org/10.1021/ja0745613

Matrix Gla protein inhibits ectopic calcification by a direct interaction with hydroxyapatite crystals

Autor: Graeme K. Hunter, Yinyin Liao, Mikko Karttunen, Jari Jalkanen, Jason O’Young, Gilles A. Lajoie, Yizhi Xiao, Harvey A. Goldberg

Publikováno v: Journal of the American Chemical Society. 133(45)

Mice lacking the gene encoding matrix gla protein (MGP) exhibit massive mineral deposition in blood vessels and die soon after birth. We hypothesize that MGP prevents arterial calcification by adsorbing to growing hydroxyapatite (HA) crystals. To tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eec3f8b24ae1f954f5c6d765807606f
https://pubmed.ncbi.nlm.nih.gov/21961692

Roles of Electrostatics and Conformation in Protein-Crystal Interactions

Autor: Graeme K. Hunter, Gilles A. Lajoie, Mikko Karttunen, Harvey A. Goldberg, Jason O’Young, Paul Azzopardi

Publikováno v: Dentistry Publications
PLoS ONE
PLoS ONE, 5(2), e9330-1/11. Public Library of Science
PLoS ONE, Vol 5, Iss 2, p e9330 (2010)

In vitro studies have shown that the phosphoprotein osteopontin (OPN) inhibits the nucleation and growth of hydroxyapatite (HA) and other biominerals. In vivo, OPN is believed to prevent the calcification of soft tissues. However, the nature of the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2406e88f95547b629ac5c23597ca238d
https://ir.lib.uwo.ca/dentistrypub/21