Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jason Neale"'
Autor:
Dennis R. Benjamin, Jason Neale, Lori Westendorf, Joshua H. Hunter, Julia H. Cochran, Vincent Feng-Sheng Shih, Michelle L. Ulrich, Fu Li
To provide a better understanding of the pharmacokinetics–pharmacodynamics relationships of antibody-based drugs, we analyzed several chimeric and humanized monoclonal antibodies or antibody–drug conjugates (ADC) for PK and efficacy among four st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8374d132b770669b196b144950686f40
https://doi.org/10.1158/1535-7163.c.6538009.v1
https://doi.org/10.1158/1535-7163.c.6538009.v1
Autor:
Dennis R. Benjamin, Jason Neale, Lori Westendorf, Joshua H. Hunter, Julia H. Cochran, Vincent Feng-Sheng Shih, Michelle L. Ulrich, Fu Li
Additional PK measurements and antibody sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a5cfc99a95240fc821025d94bd15b7
https://doi.org/10.1158/1535-7163.22505254
https://doi.org/10.1158/1535-7163.22505254
Autor:
Peter D. Senter, Robert P. Lyon, Weiping Zeng, Margo C. Zaval, Abbie Wong, Andrew B. Waight, Michelle L. Ulrich, Jessica K. Simmons, Paul G. Pittman, Jay C. Nix, Jason Neale, David W. Meyer, Luke V. Loftus, Fu Li, Steven Jin, Julia H. Cochran, Martha E. Anderson, Kathleen C. Olivas, Christopher S. Neumann
Detailed methods for ADC analytics and chemical sysnthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916122efb9c585694b4a5165b3263a57
https://doi.org/10.1158/1535-7163.22505815
https://doi.org/10.1158/1535-7163.22505815
Autor:
Peter D. Senter, Robert P. Lyon, Weiping Zeng, Margo C. Zaval, Abbie Wong, Andrew B. Waight, Michelle L. Ulrich, Jessica K. Simmons, Paul G. Pittman, Jay C. Nix, Jason Neale, David W. Meyer, Luke V. Loftus, Fu Li, Steven Jin, Julia H. Cochran, Martha E. Anderson, Kathleen C. Olivas, Christopher S. Neumann
Antibody–drug conjugates (ADCs) are a therapeutic modality that enables the targeted delivery of cytotoxic drugs to cancer cells. Identification of active payloads with unique mechanisms of action is a key aim of research efforts in the field. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::573a206071ce06934ff2470390402a2e
https://doi.org/10.1158/1535-7163.c.6538195.v1
https://doi.org/10.1158/1535-7163.c.6538195.v1
Autor:
Peter D. Senter, Robert P. Lyon, Weiping Zeng, Margo C. Zaval, Abbie Wong, Andrew B. Waight, Michelle L. Ulrich, Jessica K. Simmons, Paul G. Pittman, Jay C. Nix, Jason Neale, David W. Meyer, Luke V. Loftus, Fu Li, Steven Jin, Julia H. Cochran, Martha E. Anderson, Kathleen C. Olivas, Christopher S. Neumann
Supplemental tables and figures referenced in main text: Table S1 - Crystallography data collection and refinement statistics; Table S2 - ADC characterization data; Figure S1 - ADC plasma stability data; Figure S2 - Time course for ADC activity in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db82a176dff235f814043a7bfa28d04
https://doi.org/10.1158/1535-7163.22505812
https://doi.org/10.1158/1535-7163.22505812
Autor:
Rahul Palchaudhuri, Junia Dushime, Jason Neale, Ganapathy N. Sarma, Bradley R. Pearse, Melissa L. Brooks, Charlotte Mcdonagh, Jennifer L. Proctor, Anthony E. Boitano, Tahirih L. Lamothe, Ryan Knihtila, Nidhi Jain, Rajiv Panwar, Qing Li, Sean McDonough, John C. Davis, Michael P. Cooke, Lena Kien, Kellie Latimer
Publikováno v:
Biology of Blood and Marrow Transplantation. 26:S35-S36
Current approaches to conditioning prior to transplant and gene therapy employ non-specific genotoxic agents that are associated with severe acute and long-term toxicities. Consequently, many transplant eligible patients either refuse transplant or r
Autor:
Julia H. Cochran, Vincent Feng-Sheng Shih, Michelle Ulrich, Joshua H. Hunter, Lori Westendorf, Fu Li, Jason Neale, Dennis Benjamin
Publikováno v:
Molecular cancer therapeutics. 18(4)
To provide a better understanding of the pharmacokinetics–pharmacodynamics relationships of antibody-based drugs, we analyzed several chimeric and humanized monoclonal antibodies or antibody–drug conjugates (ADC) for PK and efficacy among four st
Autor:
Lukasz Biernat, Dwight M. Morrow, Veit Schmelmer, Patrick C. Falahee, Jason Neale, Kevin A. Goncalves, Glen D. Raffel, Michael P. Cooke, John F. DiPersio, John C. Davis, Steven M. Devine, Jonathan Hoggatt, Haley Howell, Anthony E. Boitano
Publikováno v:
Blood. 134:1961-1961
Background Granulocyte colony-stimulating factor (G-CSF) is the standard of care for mobilization of hematopoietic stem cells (HSCs). G-CSF requires 4-7 days of injections and often multiple aphereses to acquire sufficient CD34+ cells for transplant.
Autor:
Julia H. Cochran, Paul G. Pittman, Steven Jin, Robert P. Lyon, Michelle Ulrich, Martha Anderson, Fu Li, Abbie Wong, Luke V. Loftus, Margo Zaval, Jay C. Nix, Jason Neale, Peter D. Senter, David W. Meyer, Jessica K. Simmons, Weiping Zeng, Andrew B. Waight, Christopher Scott Neumann, Kathleen C. Olivas
Publikováno v:
Molecular cancer therapeutics. 17(12)
Antibody–drug conjugates (ADCs) are a therapeutic modality that enables the targeted delivery of cytotoxic drugs to cancer cells. Identification of active payloads with unique mechanisms of action is a key aim of research efforts in the field. Here
Publikováno v:
IEEE Transactions on Aerospace and Electronic Systems. 49:451-467
This paper describes the design, analysis, and evaluation of new ionospheric measurement error models for high-integrity multiconstellation navigation systems, The robustness of the newly derived models is experimentally evaluated using months of dua