Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jason N. Abrams"'
Publikováno v:
Tetrahedron. 68:423-428
A functionally enriched ABCD ring system of podophyllotoxin was generated through Pd(II)-templated cyclization of an alkynoic alkene, prepared in five steps from commercially available 6-bromopiperonal. This research expands upon the recent carboeste
Autor:
Saul H. Rosenberg, Tongmei Li, Gui-Dong Zhu, Keith W. Woods, Jason N. Abrams, Jürgen Dinges, Eric F. Johnson, Tilman Oltersdorf, Clarissa G. Jakob, Qun Li, John E. Fisher, Xuesong Liu, Vincent S. Stoll, Garrick Packard, Ron Des Jong, Sheela A. Thomas, Vincent L. Giranda, Xiaohong Song, Yan Luo, Vered Klinghofer, Jianchun Gong, Yan Shi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2000-2007
Structure-based design and synthesis of the 3,4'-bispyridinylethylene series led to the discovery of 3-isoquinolinylpyridine 13a as a potent PKB/Akt inhibitor with an IC(50) of 1.3nM against Akt1. Compound 13a shows excellent selectivity against dist
Autor:
Craig J. Forsyth, Gordon J. Florence, Jason N. Abrams, Priscilla Lugo-Mas, T. Matthew Hansen, Jiehao Chen
Publikováno v:
Tetrahedron Letters. 44:57-59
The selective oxidative conversion of a variety of highly functionalized 1°,2°-1,5-diols into the corresponding δ-lactones has been effected simply and efficiently using a reagent system comprised of catalytic 2,2,6,6-tetrmethylpiperidinooxy (TEMP
Autor:
Rachel P. M. Abrams, Jason N. Abrams, Ion Ghiviriga, Igor V. Alabugin, Vitaliy I. Timokhin, Mariappan Manoharan
Publikováno v:
Journal of the American Chemical Society. 130(33)
Despite being predicted to be stereoelectronically favorable by the Baldwin rules, efficient formation of a C-C bond through a 5-endo-dig radical cyclization remained unknown for more than 40 years. This work reports a remarkable increase in the effi