Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jason Munguia"'
Autor:
Leo Lin, Poochit Nonejuie, Jason Munguia, Andrew Hollands, Joshua Olson, Quang Dam, Monika Kumaraswamy, Heriberto Rivera Jr., Ross Corriden, Manfred Rohde, Mary E. Hensler, Michael D. Burkart, Joe Pogliano, George Sakoulas, Victor Nizet
Publikováno v:
EBioMedicine, Vol 2, Iss 7, Pp 690-698 (2015)
Antibiotic resistance poses an increasingly grave threat to the public health. Of pressing concern, rapid spread of carbapenem-resistance among multidrug-resistant (MDR) Gram-negative rods (GNR) is associated with few treatment options and high morta
Externí odkaz:
https://doaj.org/article/e18293e0ce8842e89a217c56927c7952
Publikováno v:
Chemical Biology & Drug Design. 93:647-652
To maintain the lipid asymmetry of the cell envelope in Gram-negative bacteria, the MlaC protein serves as a lipid-transfer factor and delivers phospholipids from the outer to the inner membrane. A strategy of antibiotic discovery is to design a prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430370e6eb56791a2084b09502149bec
https://doi.org/10.1111/cbdd.13462
https://doi.org/10.1111/cbdd.13462
Autor:
Doris L. LaRock, Joshua Olson, Hannah Tsunemoto, Joe Pogliano, Ingrid Cornax, Jason Munguia, Victor Nizet
Publikováno v:
Journal of molecular medicine (Berlin, Germany), vol 95, iss 10
Pseudomonas aeruginosa is an important opportunistic pathogen that has become a serious problem due to increased rates of antibiotic resistance. Due to this along with a dearth in novel antibiotic development, especially against Gram-negative pathoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eecefd21da593a6f5dc6c71131a25041
https://doi.org/10.1007/s00109-017-1579-4
https://doi.org/10.1007/s00109-017-1579-4
Autor:
Victor Nizet, Jason Munguia
Publikováno v:
Trends in Pharmacological Sciences. 38:473-488
The rise of multidrug-resistant pathogens and the dearth of new antibiotic development place an existential strain on successful infectious disease therapy. Breakthrough strategies that go beyond classical antibiotic mechanisms are needed to combat t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb80b67d172d1e051e178c1f5cb0dea
https://doi.org/10.1016/j.tips.2017.02.003
https://doi.org/10.1016/j.tips.2017.02.003
Autor:
Victor Nizet, Max Crüsemann, Jason Munguia, Takayoshi Awakawa, Nadine Ziemert, Bradley S. Moore, William Fenical
Publikováno v:
ChemBioChem. 16:1443-1447
Salinipyrones and pacificanones are structurally related polyketides from Salinispora pacifica CNS-237 that are proposed to arise from the same modular polyketide synthase (PKS) assembly line. Genome sequencing revealed a large macrolide PKS gene clu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc7e2935e1476210aa7da0b4a7802353
https://doi.org/10.1002/cbic.201500177
https://doi.org/10.1002/cbic.201500177
Autor:
Poochit Nonejuie, Joshua Olson, Eleanna Sakoulas, George Sakoulas, Jason Munguia, Michael J. Rybak, Joe Pogliano, Warren E. Rose, Victor Nizet, Andrew D. Berti
Publikováno v:
Antimicrobial agents and chemotherapy, vol 61, iss 2
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy
We asked whether beta-lactamase inhibitors (BLIs) increased the activity of daptomycin (DAP) against methicillin-resistant Staphylococcus aureus (MRSA), the peptide antibiotic colistin (COL) against the emerging Gram-negative nosocomial pathogen Acin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d111c6c258400eca62c90c95a1701653
https://escholarship.org/uc/item/6w1597ds
https://escholarship.org/uc/item/6w1597ds
Autor:
Stanley J. Opella, Mark Skasko, John C. Guatelli, Andrey Tokarev, Yan Wang, Edward B. Stephens, Autumn Ruiz, Ye Tian, Jason Munguia
Publikováno v:
Journal of Biological Chemistry. 287:58-67
The Vpu protein of HIV-1 antagonizes BST-2 (tetherin), a broad spectrum effector of the innate immune response to viral infection, by an intermolecular interaction that maps genetically to the α-helical transmembrane domains (TMDs) of each protein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400daa8de3de952b473b68da46fad369
https://doi.org/10.1074/jbc.m111.296772
https://doi.org/10.1074/jbc.m111.296772
Publikováno v:
Journal of Virology. 85:51-63
The HIV-1 protein Vpu counteracts the antiviral activity of the innate restriction factor BST-2/tetherin by a mechanism that partly depends on its interaction with β-TrCP, a substrate adaptor for an SCF (Skp-Cullin 1-F box) E3 ubiquitin ligase compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d3fd4b77071b4b743b084fc9f48868
https://doi.org/10.1128/jvi.01795-10
https://doi.org/10.1128/jvi.01795-10
Autor:
Andrew Hollands, Victor Nizet, Quang Dam, Monika Kumaraswamy, Leo Lin, Poochit Nonejuie, Joshua Olson, Ross Corriden, Jason Munguia, Joe Pogliano, Heriberto Rivera, George Sakoulas, Manfred Rohde, Mary E. Hensler, Michael D. Burkart
Publikováno v:
EBioMedicine, Vol 2, Iss 7, Pp 690-698 (2015)
Antibiotic resistance poses an increasingly grave threat to the public health. Of pressing concern, rapid spread of carbapenem-resistance among multidrug-resistant (MDR) Gram-negative rods (GNR) is associated with few treatment options and high morta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0cec5a340e2e01c9a99940f35a9a32