Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jason Mick"'
Autor:
Younes Nejahi, Mohammad Soroush Barhaghi, Jason Mick, Brock Jackman, Kamel Rushaidat, Yuanzhe Li, Loren Schwiebert, Jeffrey Potoff
Publikováno v:
SoftwareX, Vol 9, Iss , Pp 20-27 (2019)
GPU Optimized Monte Carlo (GOMC) is open-source software for simulating molecular systems using the Metropolis Monte Carlo algorithm. It supports simulations in a variety of ensembles, which include canonical, isothermal–isobaric, grand canonical,
Externí odkaz:
https://doaj.org/article/4a046e4bbe4a43049a620b38eaf49482
Autor:
Luis Bering, Elliott J. Craven, Stanley A. Sowerby Thomas, Sarah A. Shepherd, Jason Micklefield
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Proteins, other metabolites and many valuable synthetic products contain amide bonds and there is a need for more sustainable amide synthesis routes. Here the authors show an integrated next generation multi-catalytic system, merging nitrile hydratas
Externí odkaz:
https://doaj.org/article/1d8666ce455b4b4bb53aab00a0d924ea
Autor:
Wei Li Thong, Yingxin Zhang, Ying Zhuo, Katherine J. Robins, Joanna K. Fyans, Abigail J. Herbert, Brian J. C. Law, Jason Micklefield
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Engineering biosynthetic assembly lines is a powerful path to new natural products but is challenging with current methods. Here the authors use CRISPR-Cas9 to exchange subdomains within NRPS to alter substrate selectivity.
Externí odkaz:
https://doaj.org/article/65ce6f9e89b844d7adc627e3f70e0f01
Autor:
Matthew Cummings, Anna D Peters, George F S Whitehead, Binuraj R K Menon, Jason Micklefield, Simon J Webb, Eriko Takano
Publikováno v:
PLoS Biology, Vol 17, Iss 7, p e3000347 (2019)
Polyketides are a class of specialised metabolites synthesised by both eukaryotes and prokaryotes. These chemically and structurally diverse molecules are heavily used in the clinic and include frontline antimicrobial and anticancer drugs such as ery
Externí odkaz:
https://doaj.org/article/970f16e4234c437a914e36237aa60a9b
Autor:
Jonathan Latham, Jean-Marc Henry, Humera H. Sharif, Binuraj R. K. Menon, Sarah A. Shepherd, Michael F. Greaney, Jason Micklefield
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Biocatalysis and metal catalysis often provide complimentary reactivities and selectivities. Here, the authors exploit the regioselectivity of an enzymatic C–H activation followed by palladium catalysed carbon-carbon bond formation in one pot, with
Externí odkaz:
https://doaj.org/article/0433d1f6927342b4876e95b9f595c6da