Výsledky vyhledávání - "Jason Matakas"

Abstract 4646: A novel truncated variant of the hematopoietic Hβ-1 tubulin isotype with implications for stem cell biology

Autor: Monica L. Guzman, Paraskevi Giannakakou, Siddhartha Sen, Silvana Di Giandomenico, Jason Matakas, Yang Bai, Paul A. Basciano, Todd Evans, Xi Li, Joseph M. Scandura

Publikováno v: Cancer Research. 77:4646-4646

The αβ-tubulin dimer is the building block of the microtubule cytoskeleton, which is important for many cellular functions. Several α and β tubulin isotypes have been identified so far; Hβ-1 tubulin (human β tubulin Class VI) is a hematopoietic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db5a169a2da717f6e1d097140fa0abfe
https://doi.org/10.1158/1538-7445.am2017-4646

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Abstract 5096: ALIBI: a novel, truncated tubulin isotype in AML and stem cells

Autor: Siddhartha Sen, Paul A. Basciano, Todd Evans, Jason Matakas, Susanna Liu, Xi Li, Silvana Di Giandomenico, Joseph M. Scandura, Monica L. Guzman, Paraskevi Giannakakou

Publikováno v: Cancer Research. 75:5096-5096

Tubulin isotype expression is tissue restricted, with β-1 tubulin (TUBB1) restricted to hematopoietic tissues. Using the TCGA database, we found that β-1 is highly expressed in acute myeloid leukemia (AML) among all hematologic malignancies. β-1 m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4247b1fbd8ac7a0ae4dee5e078b95bca
https://doi.org/10.1158/1538-7445.am2015-5096

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β-1 tubulin R307H SNP alters microtubule dynamics and affects severity of a hereditary thrombocytopenia

Autor: P. Burger, Claudia Cagioni, Paul J. Christos, Paraskevi Giannakakou, James B. Bussel, Patrizia Noris, Elisa Civaschi, Paul A. Basciano, James P. Snyder, N. Bompiani, Jason Matakas, Carlo L. Balduini, Alessandro Pecci

Publikováno v: Europe PubMed Central

SummaryBackground Single nucleotide polymorphisms (SNPs) in platelet-associated genes partly explain inherent variability in platelet counts. Patients with monoallelic Bernard Soulier syndrome due to the Bolzano mutation (GPIBA A156V) have variable p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c46b5aa08a66fab75dba46c5209d390
http://europepmc.org/abstract/med/25529050

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