Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Jason Madore"'
Autor:
Jing Liu, Jake S. O’Donnell, Juming Yan, Jason Madore, Stacey Allen, Mark J. Smyth, Michele W. L. Teng
Publikováno v:
OncoImmunology, Vol 8, Iss 5 (2019)
Adjuvant immunotherapies targeting CTLA4 or PD-1 recently demonstrated efficacy in the treatment of earlier stages of human cancer. We previously demonstrated using mouse spontaneous metastasis models that neoadjuvant immunotherapy and surgery was su
Externí odkaz:
https://doaj.org/article/540ebb5775024460ba49e196c3a62cae
Autor:
Hansol Lee, Camelia Quek, Ines Silva, Annie Tasker, Marcel Batten, Helen Rizos, Su Yin Lim, Tuba Nur Gide, Ping Shang, Grace H. Attrill, Jason Madore, Jarem Edwards, Matteo S. Carlino, Alexander Guminski, Robyn P.M. Saw, John F. Thompson, Peter M. Ferguson, Umaimainthan Palendira, Alexander M. Menzies, Georgina V. Long, Richard A. Scolyer, James S. Wilmott
Publikováno v:
OncoImmunology, Vol 8, Iss 2 (2019)
Purpose: Anti-PD-1 therapy has revolutionized the treatment and improved the survival of stage IV melanoma patients. However, almost half of the patients fail to respond due to immune evasive mechanism. A known mechanism is the downregulation of majo
Externí odkaz:
https://doaj.org/article/99ab392d7e6b45fbb50cf5649f13f283
Autor:
Paulina M Wojnarowicz, Kathleen Klein Oros, Michael C J Quinn, Suzanna L Arcand, Karen Gambaro, Jason Madore, Ashley H Birch, Manon de Ladurantaye, Kurosh Rahimi, Diane M Provencher, Anne-Marie Mes-Masson, Celia M T Greenwood, Patricia N Tonin
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45484 (2012)
High-grade ovarian serous carcinomas (HGSC) are characterized by TP53 mutations and non-random patterns of chromosomal anomalies, where the nature of the TP53 mutation may correlate with clinical outcome. However, the frequency of common somatic geno
Externí odkaz:
https://doaj.org/article/9467faaf430c4f4db00a32587a331be2
Autor:
Cécile Le Page, Alexandre Marineau, Patrick K Bonza, Kurosh Rahimi, Louis Cyr, Ingrid Labouba, Jason Madore, Nathalie Delvoye, Anne-Marie Mes-Masson, Diane M Provencher, Jean-François Cailhier
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38541 (2012)
BTN3A2/BT3.2 butyrophilin mRNA expression by tumoral cells was previously identified as a prognostic factor in a small cohort of high grade serous epithelial ovarian cancer (HG-EOC). Here, we evaluated the prognostic value of BT3.2 at the protein lev
Externí odkaz:
https://doaj.org/article/38e95f9d6a5d4ea2b38635725fdbb76e
Autor:
Anne Hakem, Miyuki Bohgaki, Bénédicte Lemmers, Elisabeth Tai, Leonardo Salmena, Elzbieta Matysiak-Zablocki, Yong-Sam Jung, Jana Karaskova, Lilia Kaustov, Shili Duan, Jason Madore, Paul Boutros, Yi Sheng, Marta Chesi, P Leif Bergsagel, Bayardo Perez-Ordonez, Anne-Marie Mes-Masson, Linda Penn, Jeremy Squire, Xinbin Chen, Igor Jurisica, Cheryl Arrowsmith, Otto Sanchez, Samuel Benchimol, Razqallah Hakem
Publikováno v:
PLoS Genetics, Vol 7, Iss 11, p e1002360 (2011)
Ubiquitylation is fundamental for the regulation of the stability and function of p53 and c-Myc. The E3 ligase Pirh2 has been reported to polyubiquitylate p53 and to mediate its proteasomal degradation. Here, using Pirh2 deficient mice, we report tha
Externí odkaz:
https://doaj.org/article/ceeccf61e253499a91010ab5fb3e09e2
Autor:
Mark J. Smyth, William C. Dougall, Robert J. Johnston, Michele W.L. Teng, Alan Korman, Nathan Siemers, Ruth Lan, Richard A. Scolyer, Georgina V. Long, Kazuyoshi Takeda, Mark L. Bettington, Cheng Liu, Vicki L.J. Whitehall, Stephen J. Blake, Kimberley Stannard, Amelia Roman Aguilera, Jason Madore, Ailin Lepletier, Deepak Mittal
Supplementary Figures 1-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b861dafb9b1ccae4d56c90e999ebc986
https://doi.org/10.1158/2326-6066.22542879.v1
https://doi.org/10.1158/2326-6066.22542879.v1
Autor:
Mark J. Smyth, William C. Dougall, Robert J. Johnston, Michele W.L. Teng, Alan Korman, Nathan Siemers, Ruth Lan, Richard A. Scolyer, Georgina V. Long, Kazuyoshi Takeda, Mark L. Bettington, Cheng Liu, Vicki L.J. Whitehall, Stephen J. Blake, Kimberley Stannard, Amelia Roman Aguilera, Jason Madore, Ailin Lepletier, Deepak Mittal
CD96 is a novel target for cancer immunotherapy shown to regulate NK cell effector function and metastasis. Here, we demonstrated that blocking CD96 suppressed primary tumor growth in a number of experimental mouse tumor models in a CD8+ T cell–dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1072b9f1ddbbae47fcb134c54fdbadd7
https://doi.org/10.1158/2326-6066.c.6550068.v1
https://doi.org/10.1158/2326-6066.c.6550068.v1
Autor:
Mark J. Smyth, William C. Dougall, Robert J. Johnston, Michele W.L. Teng, Alan Korman, Nathan Siemers, Ruth Lan, Richard A. Scolyer, Georgina V. Long, Kazuyoshi Takeda, Mark L. Bettington, Cheng Liu, Vicki L.J. Whitehall, Stephen J. Blake, Kimberley Stannard, Amelia Roman Aguilera, Jason Madore, Ailin Lepletier, Deepak Mittal
Supp Methods and Legends S1-S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a701e5d266e74d41259ec23a4e0ea52
https://doi.org/10.1158/2326-6066.22542876.v1
https://doi.org/10.1158/2326-6066.22542876.v1
Autor:
Mark J. Smyth, Michele W. L. Teng, Courtney Beers, Nishamol Geetha, Tobias Bald, Corey Smith, Nicola Waddell, Rebecca L. Johnston, Simon C. Robson, Michael Hölzel, Maike Effern, Ana C. Anderson, John Corbin, Vanessa B. Soros, Bradley N. Spatola, Alana G. Lerner, Megan Welch, Tracy dela Cruz, Clifford Wong, Celia Jacoberger-Foissac, Ashmitha Sundarrajan, Amelia Roman Aguilera, Ailin Lepletier, Jason Madore, Haiyan Zhang, Mika Casey, Kyohei Nakamura, Christos Xiao, Achim K. Moesta, Xian-Yang Li
Supplementary Methods, Figures, Legends and Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d59e57662c63e9b64230b5f2cdb85d0
https://doi.org/10.1158/2159-8290.22537072.v1
https://doi.org/10.1158/2159-8290.22537072.v1
Autor:
Mark J. Smyth, Michele W. L. Teng, Courtney Beers, Nishamol Geetha, Tobias Bald, Corey Smith, Nicola Waddell, Rebecca L. Johnston, Simon C. Robson, Michael Hölzel, Maike Effern, Ana C. Anderson, John Corbin, Vanessa B. Soros, Bradley N. Spatola, Alana G. Lerner, Megan Welch, Tracy dela Cruz, Clifford Wong, Celia Jacoberger-Foissac, Ashmitha Sundarrajan, Amelia Roman Aguilera, Ailin Lepletier, Jason Madore, Haiyan Zhang, Mika Casey, Kyohei Nakamura, Christos Xiao, Achim K. Moesta, Xian-Yang Li
We explored the mechanism of action of CD39 antibodies that inhibit ectoenzyme CD39 conversion of extracellular ATP (eATP) to AMP and thus potentially augment eATP–P2-mediated proinflammatory responses. Using syngeneic and humanized tumor models, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030175f55343048c09aeca7a10f290c0
https://doi.org/10.1158/2159-8290.c.6548314.v1
https://doi.org/10.1158/2159-8290.c.6548314.v1