Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jason M. Tonne"'
Autor:
Katherine E. R. Smith, Kah-Whye Peng, Jose S. Pulido, Adam J. Weisbrod, Carrie A. Strand, Jacob B. Allred, Alysha N. Newsom, Lianwen Zhang, Nandakumar Packiriswamy, Timothy Kottke, Jason M. Tonne, Madelyn Moore, Heather N. Montane, Lisa A. Kottschade, Robert R. McWilliams, Arkadiusz Z. Dudek, Yiyi Yan, Anastasios Dimou, Svetomir N. Markovic, Mark J. Federspiel, Richard G. Vile, Roxana S. Dronca, Matthew S. Block
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionMetastatic uveal melanoma (MUM) has a poor prognosis and treatment options are limited. These patients do not typically experience durable responses to immune checkpoint inhibitors (ICIs). Oncolytic viruses (OV) represent a novel approach
Externí odkaz:
https://doaj.org/article/0a92140d4f6e43bc9b4331d5a320712f
Autor:
Elizabeth C. Eckert, Rebecca A. Nace, Jason M. Tonne, Laura Evgin, Richard G. Vile, Stephen J. Russell
Publikováno v:
Molecular Therapy: Oncolytics, Vol 16, Iss , Pp 63-74 (2020)
Genetically modified vesicular stomatitis virus (VSV) is an attractive agent for cancer treatment due to rapid intratumoral replication and observed clinical responses. Although VSV selectively kills malignant cells and can boost antitumor immunity,
Externí odkaz:
https://doaj.org/article/5bc51a5e074e4c1d8f38884a5ba05a79
Autor:
Christopher B. Driscoll, Matthew R. Schuelke, Timothy Kottke, Jill M. Thompson, Phonphimon Wongthida, Jason M. Tonne, Amanda L. Huff, Amber Miller, Kevin G. Shim, Amy Molan, Cynthia Wetmore, Peter Selby, Adel Samson, Kevin Harrington, Hardev Pandha, Alan Melcher, Jose S. Pulido, Reuben Harris, Laura Evgin, Richard G. Vile
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
DNA mutations induced by dysregulated APOBEC3 expression are associated with tumour-progression and therapeutic resistance, but also with the generation of neoepitopes. Here, the authors show that APOBEC3 function can be exploited in a vaccine settin
Externí odkaz:
https://doaj.org/article/0b522666697f4ba891fb72be5cba002f
Autor:
Yaxi Zhu, Jason M. Tonne, Qian Liu, Claire A. Schreiber, Zhiguang Zhou, Kuntol Rakshit, Aleksey V. Matveyenko, Andre Terzic, Dennis Wigle, Yogish C. Kudva, Yasuhiro Ikeda
Publikováno v:
Stem Cell Reports, Vol 13, Iss 2, Pp 307-321 (2019)
Summary: Generation of functional β cells from pluripotent sources would accelerate diagnostic and therapeutic applications for diabetes research and therapy. However, it has been challenging to generate competent β cells with dynamic insulin-secre
Externí odkaz:
https://doaj.org/article/5560a206141740e1b439ccf39e142bc3
Publikováno v:
Biochemistry and Biophysics Reports, Vol 17, Iss , Pp 108-113 (2019)
Hyperinsulinemic hypoglycemia subtype glucokinase (GCK-HH) is caused by an activating mutation in glucokinase (GCK) and has been shown to increase β-cell death. However, the mechanism of β-cell death in GCK-HH remains poorly understood. Here, we ex
Externí odkaz:
https://doaj.org/article/3c614410cd9f470f81e7685f07101767
Autor:
Salma G. Morsy, Jason M. Tonne, Yaxi Zhu, Brian Lu, Karol Budzik, James W. Krempski, Sherine A. Ali, Mohamed A. El-Feky, Yasuhiro Ikeda
Publikováno v:
BMC Research Notes, Vol 10, Iss 1, Pp 1-7 (2017)
Abstract Objective Recombinant adeno-associated virus (AAV)-based vectors are characterized by their robust and safe transgene delivery. The CRISPR/Cas9 and guide RNA (gRNA) system present a promising genome-editing platform, and a recent development
Externí odkaz:
https://doaj.org/article/08fb99c2192749669f3d9f97c87e48b9
Publikováno v:
Viruses, Vol 6, Iss 3, Pp 1135-1148 (2014)
Previously we reported that nuclear export of both unspliced and spliced murine leukemia virus (MLV) transcripts depends on the nuclear export factor (NXF1) pathway. Although the mRNA export complex TREX, which contains Aly/REF, UAP56, and the THO co
Externí odkaz:
https://doaj.org/article/00f9c43927fb42279f4cf2e21a330a4b
Autor:
Jason M. Tonne, Toshie Sakuma, Michael C. Deeds, Miguel Munoz-Gomez, Michael A. Barry, Yogish C. Kudva, Yasuhiro Ikeda
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 5, Pp 1236-1245 (2013)
SUMMARY Streptozotocin (STZ), a glucosamine-nitrosourea compound, has potent genotoxic effects on pancreatic β-cells and is frequently used to induce diabetes in experimental animals. Glucagon-like peptide-1 (GLP-1) has β-cell protective effects an
Externí odkaz:
https://doaj.org/article/7d81d4fcdf9643f88421ebc9f2dc8274
Autor:
Timothy Kottke, Laura Evgin, Christopher B. Driscoll, Phonphimon Wongthida, Jill Thompson, Brady Zell, Adel Samson, Jason M. Tonne, Amanda L. Huff, Lewis R. Roberts, Elizabeth Ilett, Peter Selby, Alan Melcher, Kevin J. Harrington, Jacob van Vloten, Mitesh J. Borad, Hardev Pandha, Matthew Schuelke, Richard G. Vile, Mark A. McNiven, Victoria A. Jennings, Jose S. Pulido
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
In our clinical trials of oncolytic vesicular stomatitis virus expressing interferon beta (VSV-IFNβ), several patients achieved initial responses followed by aggressive relapse. We show here that VSV-IFNβ-escape tumors predictably express a point-m
Autor:
Dileep D. Monie, Sarah L. Young, Tim Kottke, Gary E. Archer, Jose S. Pulido, Laura Evgin, Matthew C. Coffey, Phonphimon Wongthida, Pierce Reynolds, Aaron J. Johnson, Amanda L. Huff, Matthew Schuelke, Luis Sanchez Perez, Richard G. Vile, Katayoun Ayasoufi, John H. Sampson, Christopher B. Driscoll, Jill Thompson, Kevin G. Shim, Jason M. Tonne
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
The application of adoptive T cell therapies, including those using chimeric antigen receptor (CAR)-modified T cells, to solid tumors requires combinatorial strategies to overcome immune suppression associated with the tumor microenvironment. Here we