Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jason M. Moran"'
Autor:
Benjamin S. Christmann, Jason M. Moran, Joshua D. Stafford, John A. Corbett, Zachary R. Shaheen, R. Mark L. Buller
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Double-stranded (ds) RNA, both synthetic and produced during virus replication, rapidly stimulates MAPK and NF-κB signaling that results in expression of the inflammatory genes inducible nitric oxide synthase, cyclooxygenase 2, and IL-1β by macroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8744f783f10fd768ef204b9472ff85cd
https://pubmed.ncbi.nlm.nih.gov/30811246
https://pubmed.ncbi.nlm.nih.gov/30811246
Publikováno v:
Journal of Virology. 79:10226-10236
In this study, we provide evidence that the double-stranded RNA-dependent protein kinase (PKR) is not required for virus-induced expression of inducible nitric oxide synthase (iNOS) or the activation of specific signaling pathways in macrophages. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e283acdc22996aa8d839045a90777b
https://doi.org/10.1128/jvi.79.16.10226-10236.2005
https://doi.org/10.1128/jvi.79.16.10226-10236.2005
Publikováno v:
Eukaryotic Cell. 4:202-208
Laccases are thought to be important to the virulence of many fungal pathogens by producing melanin, a presumed oxygen radical scavenger. A laccase in Cryptococcus neoformans has been shown to synthesize melanin and contributes to the virulence and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165b151c925a86c3ddf1fefb9ff4ae19
https://doi.org/10.1128/ec.4.1.202-208.2005
https://doi.org/10.1128/ec.4.1.202-208.2005
Publikováno v:
Journal of Biological Chemistry. 278:16683-16689
Double-stranded (ds) RNA, which accumulates during viral replication, activates the antiviral response of infected cells. In this study, we have identified a requirement for extracellular signal-regulated kinase (ERK) in the regulation of interleukin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1037ea0bd43ba91357cabea79b3a7742
https://doi.org/10.1074/jbc.m211744200
https://doi.org/10.1074/jbc.m211744200
Autor:
Sarah A. Steer, Jason M. Moran, John A. Corbett, Leonard B. Maggi, Harris Perlman, R. Mark L. Buller
Publikováno v:
The Journal of Immunology. 170:1070-1076
In this study the regulation of macrophage expression of cyclooxygenase-2 (COX-2) in response to dsRNA and virus infection was examined. Treatment of RAW 264.7 macrophages with dsRNA results in COX-2 mRNA accumulation and protein expression and the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3517073752f22e7a9ad5cbff7481105d
https://doi.org/10.4049/jimmunol.170.2.1070
https://doi.org/10.4049/jimmunol.170.2.1070
Autor:
Jason M. Moran, Benjamin S. Christmann, R. Mark L. Buller, Jennifer A. McGraw, John A. Corbett
Encephalomyocarditis virus (EMCV) is capable of stimulating inflammatory gene expression by macrophages as a result of interactions between EMCV capsid proteins and cell surface receptors. In this study, biochemical and genetic approaches identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5b2c80860abed8c645aec930004530
https://europepmc.org/articles/PMC3260827/
https://europepmc.org/articles/PMC3260827/
Autor:
R. Mark L. Buller, Nathan H. Lents, Joseph J. Baldassare, Jason M. Moran, Wieke Freudenburg, John A. Corbett
Publikováno v:
Journal of innate immunity. 2(1)
Virus infection of macrophages stimulates the expression of proinflammatory and antiviral genes interleukin-1 (IL-1), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). In this study, we show that phosphatidylinositol 3-kinase (PI3K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34c3dbed425a9f96108529aff491659
https://pubmed.ncbi.nlm.nih.gov/20375625
https://pubmed.ncbi.nlm.nih.gov/20375625
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 177(5)
In response to virus infection or treatment with dsRNA, macrophages express the inducible form of cyclooxygenase-2 (COX-2) and produce proinflammatory prostaglandins. Recently, we have shown that NF-κB is required for encephalomyocarditis virus (EMC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08fa77f439cc23691598755e6f00b1c
https://pubmed.ncbi.nlm.nih.gov/16920983
https://pubmed.ncbi.nlm.nih.gov/16920983
Autor:
David A. Ford, Ji-Won Yoon, Jane McHowat, John A. Corbett, Leonard B. Maggi, R. Mark L. Buller, Anna L. Scarim, Jason M. Moran
Publikováno v:
The Journal of biological chemistry. 277(41)
The double-stranded (ds) RNA-dependent protein kinase (PKR) is a primary regulator of antiviral responses; however, the ability of dsRNA to activate nuclear factor-kappa B (NF-kappa B) and dsRNA + interferon gamma (IFN-gamma) to stimulate inducible n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de38e3b8ee035a2ec0079392fd6bc26b
https://pubmed.ncbi.nlm.nih.gov/12167650
https://pubmed.ncbi.nlm.nih.gov/12167650