Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Jason M. Held"'
Autor:
Ashenafi Bulle, Peng Liu, Kuljeet Seehra, Sapana Bansod, Yali Chen, Kiran Zahra, Vikas Somani, Iftikhar Ali Khawar, Hung-Po Chen, Paarth B. Dodhiawala, Lin Li, Yutong Geng, Chia-Kuei Mo, Jay Mahsl, Li Ding, Ramaswamy Govindan, Sherri Davies, Jacqueline Mudd, William G. Hawkins, Ryan C. Fields, David G. DeNardo, Deborah Knoerzer, Jason M. Held, Patrick M. Grierson, Andrea Wang-Gillam, Marianna B. Ruzinova, Kian-Huat Lim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Targeting the mitogen-activated protein kinase (MAPK) cascade in pancreatic ductal adenocarcinoma (PDAC) remains clinically unsuccessful. We aim to develop a MAPK inhibitor-based therapeutic combination with strong preclinical efficacy. Util
Externí odkaz:
https://doaj.org/article/fb6737dcacf54c9e884795a4aec86099
Publikováno v:
Cell Reports, Vol 35, Iss 1, Pp 108949- (2021)
Summary: The colon epithelium is a primary point of interaction with the microbiome and is regenerated by a few rapidly cycling colonic stem cells (CSCs). CSC self-renewal and proliferation are regulated by growth factors and the presence of bacteria
Externí odkaz:
https://doaj.org/article/ec39f11b3cdd4352a1b152250bd69f70
Autor:
Jenna L. Clements, Franziska Pohl, Pandi Muthupandi, Stephen C. Rogers, Jack Mao, Allan Doctor, Vladimir B. Birman, Jason M. Held
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101707- (2020)
S-nitrosation of cysteine thiols (SNOs), commonly referred to as S-nitrosylation, is a cysteine oxoform that plays an important role in cellular signaling and impacts protein function and stability. Direct labeling of SNOs in cells with the flexibili
Externí odkaz:
https://doaj.org/article/eb6f5219e21f48d8bd7d8ab581bdcec2
Autor:
Ben C. Collins, Christie L. Hunter, Yansheng Liu, Birgit Schilling, George Rosenberger, Samuel L. Bader, Daniel W. Chan, Bradford W. Gibson, Anne-Claude Gingras, Jason M. Held, Mio Hirayama-Kurogi, Guixue Hou, Christoph Krisp, Brett Larsen, Liang Lin, Siqi Liu, Mark P. Molloy, Robert L. Moritz, Sumio Ohtsuki, Ralph Schlapbach, Nathalie Selevsek, Stefani N. Thomas, Shin-Cheng Tzeng, Hui Zhang, Ruedi Aebersold
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
SWATH-mass spectrometry consists of a data-independent acquisition and a targeted data analysis strategy that aims to maintain the favorable quantitative characteristics on the scale of thousands of proteins. Here, using data generated by eleven grou
Externí odkaz:
https://doaj.org/article/44740b6f8c2d466ca5462d8455eae709
Autor:
Kuan-lin Huang, Shunqiang Li, Philipp Mertins, Song Cao, Harsha P. Gunawardena, Kelly V. Ruggles, D. R. Mani, Karl R. Clauser, Maki Tanioka, Jerry Usary, Shyam M. Kavuri, Ling Xie, Christopher Yoon, Jana W Qiao, John Wrobel, Matthew A. Wyczalkowski, Petra Erdmann-Gilmore, Jacqueline E. Snider, Jeremy Hoog, Purba Singh, Beifang Niu, Zhanfang Guo, Sam Qiancheng Sun, Souzan Sanati, Emily Kawaler, Xuya Wang, Adam Scott, Kai Ye, Michael D. McLellan, Michael C. Wendl, Anna Malovannaya, Jason M. Held, Michael A. Gillette, David Fenyö, Christopher R. Kinsinger, Mehdi Mesri, Henry Rodriguez, Sherri R. Davies, Charles M. Perou, Cynthia Ma, R. Reid Townsend, Xian Chen, Steven A. Carr, Matthew J. Ellis, Li Ding
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Patient-derived xenografts recapitulate major genomic signatures and transcriptome profiles of their original tumours. Here, the authors, performing proteomic and phosphoproteomic analyses of 24 breast cancer PDX models, demonstrate that druggable ca
Externí odkaz:
https://doaj.org/article/1c26a6238dc4471f89a26c07ab836e61
Autor:
Pedro Reis Rodrigues, Tiffany K. Kaul, Jo-Hao Ho, Mark Lucanic, Kristopher Burkewitz, William B. Mair, Jason M. Held, Laura M. Bohn, Matthew S. Gill
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 6, Pp 1695-1705 (2016)
Under adverse environmental conditions the nematode Caenorhabditis elegans can enter an alternate developmental stage called the dauer larva. To identify lipophilic signaling molecules that influence this process, we screened a library of bioactive l
Externí odkaz:
https://doaj.org/article/bcf733c1a23e4a328fb0ad6cb05baf2a
Autor:
Kuan-lin Huang, Shunqiang Li, Philipp Mertins, Song Cao, Harsha P. Gunawardena, Kelly V. Ruggles, D. R. Mani, Karl R. Clauser, Maki Tanioka, Jerry Usary, Shyam M. Kavuri, Ling Xie, Christopher Yoon, Jana W. Qiao, John Wrobel, Matthew A. Wyczalkowski, Petra Erdmann-Gilmore, Jacqueline E. Snider, Jeremy Hoog, Purba Singh, Beifang Niu, Zhanfang Guo, Sam Qiancheng Sun, Souzan Sanati, Emily Kawaler, Xuya Wang, Adam Scott, Kai Ye, Michael D. McLellan, Michael C. Wendl, Anna Malovannaya, Jason M. Held, Michael A. Gillette, David Fenyö, Christopher R. Kinsinger, Mehdi Mesri, Henry Rodriguez, Sherri R. Davies, Charles M. Perou, Cynthia Ma, R. Reid Townsend, Xian Chen, Steven A. Carr, Matthew J. Ellis, Li Ding
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-1 (2017)
Nature Communications 8: Article number: 14864 (2017)); Published: 28 March 2017; Updated: 25 April 2017 The original version of this Article contained a typographical error in the spelling of the author Beifang Niu, which was incorrectly given as Be
Externí odkaz:
https://doaj.org/article/cd9fe4cc0cda4193adce8eb3c0e83927
Autor:
Christopher C. Benz, Bradford W. Gibson, Michael A. Baldwin, Birgit Schilling, Elbert L. Lee, Gary K. Scott, David J. Britton, Jason M. Held
PDF file - 132K, S1 Differential phosphorylation of ERalpha following E2 or growth factor stimulation. S2 Stable isotope dilution MRM (SID-MRM) quantitation of Ser294 and Ser167 using heavy-labeled synthetic peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b765c495e8cfc342fde67e7002c8dcc9
https://doi.org/10.1158/1541-7786.22516891
https://doi.org/10.1158/1541-7786.22516891
Autor:
Christopher C. Benz, Bradford W. Gibson, Michael A. Baldwin, Birgit Schilling, Elbert L. Lee, Gary K. Scott, David J. Britton, Jason M. Held
Phosphorylation of estrogen receptor-α (ERα) is critical for its transcription factor activity and may determine its predictive and therapeutic value as a biomarker for ERα-positive breast cancers. Recent attention has turned to the poorly underst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18b19f255076d41d427a54d190d6f2d0
https://doi.org/10.1158/1541-7786.c.6541531
https://doi.org/10.1158/1541-7786.c.6541531
Autor:
Christopher C. Benz, Bradford W. Gibson, Michael A. Baldwin, Birgit Schilling, Elbert L. Lee, Gary K. Scott, David J. Britton, Jason M. Held
PDF file - 131K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a7d97086c5bb8b6594a714258da4b9
https://doi.org/10.1158/1541-7786.22516888.v1
https://doi.org/10.1158/1541-7786.22516888.v1