Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Jason M. Haugh"'
Autor:
Jamie L Nosbisch, Anisur Rahman, Krithika Mohan, Timothy C Elston, James E Bear, Jason M Haugh
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007708 (2020)
Chemotaxis of fibroblasts and other mesenchymal cells is critical for embryonic development and wound healing. Fibroblast chemotaxis directed by a gradient of platelet-derived growth factor (PDGF) requires signaling through the phospholipase C (PLC)/
Externí odkaz:
https://doaj.org/article/38c879e4765f4fdea7a92e4d6401cb93
Publikováno v:
Molecular Biology of the Cell. 34
Live-cell microscopy is used to infer dynamics in single cells. Here, ERK signaling was monitored using four different biosensors in a common cell context. Each responds with unique kinetics, reflecting differences in ERK localization and activity. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7cca4b3ac9052d4af83441176029c64
https://doi.org/10.1091/mbc.e22-10-0476
https://doi.org/10.1091/mbc.e22-10-0476
Autor:
Scott A. Baldwin, Jason M. Haugh
Publikováno v:
Journal of Theoretical Biology. 568:111506
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85cb7d268b9a9e47f1a352fb99973f31
https://doi.org/10.1016/j.jtbi.2023.111506
https://doi.org/10.1016/j.jtbi.2023.111506
Autor:
Shoeb Ahmed, Kyle G Grant, Laura E Edwards, Anisur Rahman, Murat Cirit, Michael B Goshe, Jason M Haugh
Publikováno v:
Molecular Systems Biology, Vol 10, Iss 1, Pp 1-14 (2014)
Abstract The extracellular signal‐regulated kinase (ERK) signaling pathway controls cell proliferation and differentiation in metazoans. Two hallmarks of its dynamics are adaptation of ERK phosphorylation, which has been linked to negative feedback
Externí odkaz:
https://doaj.org/article/e26963a76c444adca5cb6a0785c501a4
Publikováno v:
Biophys J
Orchestration of cell migration is essential for development, tissue regeneration, and the immune response. This dynamic process integrates adhesion, signaling, and cytoskeletal subprocesses across spatial and temporal scales. In mesenchymal cells, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155b3b063ee3745250691300bc35f105
https://europepmc.org/articles/PMC8758409/
https://europepmc.org/articles/PMC8758409/
Autor:
James E. Bear, Shawn M. Van Bruggen, Joseph M. Koelbl, Scott A. Baldwin, Jason M. Haugh, Ravikanth Appalabhotla
Publikováno v:
Biomicrofluidics
Microfluidics approaches have gained popularity in the field of directed cell migration, enabling control of the extracellular environment and integration with live-cell microscopy; however, technical hurdles remain. Among the challenges are the stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7f30eabc373bc06c0eb973eb7e0c35
https://europepmc.org/articles/PMC8282348/
https://europepmc.org/articles/PMC8282348/
Autor:
Callie J. Miller, Sreeja B. Asokan, Jason M. Haugh, Timothy C. Elston, Paul K. LaFosse, James E. Bear
Publikováno v:
Integr Biol (Camb)
We used particle-based computer simulations to study the emergent properties of the actomyosin cytoskeleton. Our model accounted for biophysical interactions between filamentous actin and non-muscle myosin II and was motivated by recent experiments d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6504093fcfb8332d40fd84bd9a40150d
https://doi.org/10.1093/intbio/zyz023
https://doi.org/10.1093/intbio/zyz023
Publikováno v:
Journal of Biological Chemistry. 298:101886
Phospholipase C-γ1 (PLC-γ1) is a receptor-proximal enzyme that promotes signal transduction through PKC in mammalian cells. Because of the complexity of PLC-γ1 regulation, a two-state (inactive/active) model does not account for the intricacy of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e5936ca2a62e9424aca6d749d2f538
https://doi.org/10.1016/j.jbc.2022.101886
https://doi.org/10.1016/j.jbc.2022.101886
Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein.
Autor:
Laura E Ott, Eui Jae Sung, Adam T Melvin, Mary K Sheats, Jason M Haugh, Kenneth B Adler, Samuel L Jones
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66512 (2013)
Myristoylated alanine-rich C-kinase substrate (MARCKS) is a ubiquitously expressed substrate of protein kinase C (PKC) that is involved in reorganization of the actin cytoskeleton. We hypothesized that MARCKS is involved in regulation of fibroblast m
Externí odkaz:
https://doaj.org/article/e7db58012a6b4262bd26d03acb55f5bc
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50975 (2012)
Inhibition of the ubiquitin-proteasome protein degradation pathway has been identified as a viable strategy for anti-tumor therapy based on its broad effects on cell proliferation. By the same token, the variety of elicited effects confounds the inte
Externí odkaz:
https://doaj.org/article/c7ef058983d2475d8dca1f1923c15a73